Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of molecular sciences
2025
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41515913/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- -A Source of Bioactive Collagen for the Cosmetic Industry. Fernandes, Raquel Oliveira, Cristiana Ferreira-Sousa, Diana Costa-Barbosa, Augusto Sampaio, Paula Reis, Luis Fidalgo, Javier Barros, Ana N Teixeira, José A Botelho, Claudia Animals Collagen Humans Keratinocytes Cosmetics Cell Movement Scyphozoa Fibroblasts Peptides Macrophages Collagen, the most abundant structural protein in animals, is fundamental for tissue integrity and regeneration. Conventional mammalian sources face limitations related to sustainability, safety, and ethical concerns, underscoring the need for alternative biomaterials. Marine organisms, particularly jellyfish, offer a promising eco-friendly collagen source. In this study, collagen and collagen-derived peptides were extracted from the cnidarian and biochemically characterized. Circular dichroism demonstrated partial loss of triple-helix structure, while SDS-PAGE revealed type I collagen related α-chains together with low-molecular-weight fragments. The hydrolyzed collagen fractions exhibited keratinocyte and fibroblast cytocompatibility and increased keratinocyte migration. Moreover, -derived peptides modulated inflammatory cytokine release in lipopolysaccharide-stimulated macrophages reducing tumor necrosis factor (TNF)-α by 38% and increasing interleukin (IL)-10 by 29%. Based on these results, a stable bioactive serum formulation incorporating collagen peptides was developed. Overall, this work demonstrates that bioactive peptides from possess immunomodulatory and regenerative potential and represent a promising new marine resource for cosmetic applications.