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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Trends in biotechnology
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41535171/ |
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Table of Contents:
- Engineered coatings containing cyclic peptides from cyanobacteria delay the development of a stable macrofouling community. Gonçalves, Catarina Pereira, Sandra Oliveira, Isabel B Preto, Marco Ribeiro, Tiago Morais, João Gomes, Luciana C Romeu, Maria João Semedo, Miguel Mergulhão, Filipe J Vasconcelos, Vitor Silva, Elisabete R Almeida, Joana R Biofouling Peptides, Cyclic Biofilms Animals Cyanobacteria Bivalvia Biofouling-the adhesion of organisms and their byproducts to submerged surfaces-poses economic and environmental challenges, highlighting the need for sustainable antifouling solutions. This study reports a proof-of-concept investigation into the environmental compatibility and field validation of natural cyclic peptides portoamides A and B (Pam) as a bio-based antifouling alternative. Pam have demonstrated antifouling activity by inhibiting mussel larval settlement and disrupting biofilm formation. Herein, the antifouling performance of Pam-engineered coatings was evaluated through anti-settlement, anti-biofilm, as well as marine field tests. Lab-scale tests revealed that Pam-based coatings (0.7 wt%) effectively reduced biofilm thickness, surface coverage, and mussel larval settlement. Field trials showed that Pam-functionalized coating prototypes outperformed a commercial biocide in use (Econea®), delaying macrofouling community establishment and contributing to enhanced antifouling effectiveness. Overall, this work supports further development of antifouling engineered systems using Pam, representing a significant technological advance (from Technology Readiness Level 3 to 6) toward sustainable marine coating systems.