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| Main Authors: | , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of biological macromolecules
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41539506/ |
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| _version_ | 1868266100199784448 |
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| author | Zhang, Wei An, Eun-Koung Kim, So-Jung Park, Hae-Bin Ryu, Dayoung Kim, Da Young Lim, Daeun You, SangGuan Lee, Peter C W Jin, Jun-O |
| author_facet | Zhang, Wei An, Eun-Koung Kim, So-Jung Park, Hae-Bin Ryu, Dayoung Kim, Da Young Lim, Daeun You, SangGuan Lee, Peter C W Jin, Jun-O Zhang, Wei An, Eun-Koung Kim, So-Jung Park, Hae-Bin Ryu, Dayoung Kim, Da Young Lim, Daeun You, SangGuan Lee, Peter C W Jin, Jun-O |
| collection | PubMed - marine biology |
| contents | Fucoidan from Costaria costata alleviated dextran sulfate sodium-induced ulcerative colitis by suppressing dendritic cell activation. Zhang, Wei An, Eun-Koung Kim, So-Jung Park, Hae-Bin Ryu, Dayoung Kim, Da Young Lim, Daeun You, SangGuan Lee, Peter C W Jin, Jun-O Animals Polysaccharides Dendritic Cells Colitis, Ulcerative Dextran Sulfate Mice Disease Models, Animal Male Phaeophyceae Cell Proliferation Fucoidan, a water-soluble polysaccharide commonly derived from seaweed, is known for its diverse biological activities. Fucoidan from Costaria costata (FCC) suppresses lipopolysaccharide (LPS)-induced sepsis and lung inflammation by inhibiting dendritic cell (DC) activation. In this study, we investigated the anti-inflammatory effect of FCC in a mouse model of ulcerative colitis (UC), which is a chronic inflammatory disease of the colon. Orally administered FCC significantly inhibited UC severity induced by dextran sulfate sodium (DSS) intake. In particular, FCC administration decreased the infiltration of T cells and neutrophils into the colon of DSS-treated mice. Furthermore, FCC suppressed the DSS-induced production of interferon-gamma (IFN-γ) and interleukin 17 (IL-17) in colonic T cells. However, FCC did not directly suppress IFN-γ and IL-17 production in CD4 T cells. FCC administration also reduced the DSS-induced increase in the number of DCs in mesenteric lymph node (mLN). Additionally, FCC suppressed DSS-induced upregulation of co-stimulators and major histocompatibility complex (MHC) molecules in mLN DCs. FCC also inhibited LPS-induced DC activation, which resulted in reduced T cell proliferation and differentiation. These findings demonstrate that oral FCC alleviates UC by targeting DCs and T cell activity, thereby highlighting its potential as a therapeutic agent for intestinal inflammation. |
| format | Artículo científico |
| id | pubmed_41539506 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | Fucoidan from Costaria costata alleviated dextran sulfate sodium-induced ulcerative colitis by suppressing dendritic cell activation. Zhang, Wei An, Eun-Koung Kim, So-Jung Park, Hae-Bin Ryu, Dayoung Kim, Da Young Lim, Daeun You, SangGuan Lee, Peter C W Jin, Jun-O Animals Polysaccharides Dendritic Cells Colitis, Ulcerative Dextran Sulfate Mice Disease Models, Animal Male Phaeophyceae Cell Proliferation Fucoidan from Costaria costata alleviated dextran sulfate sodium-induced ulcerative colitis by suppressing dendritic cell activation. Zhang, Wei An, Eun-Koung Kim, So-Jung Park, Hae-Bin Ryu, Dayoung Kim, Da Young Lim, Daeun You, SangGuan Lee, Peter C W Jin, Jun-O Animals Polysaccharides Dendritic Cells Colitis, Ulcerative Dextran Sulfate Mice Disease Models, Animal Male Phaeophyceae Cell Proliferation Fucoidan, a water-soluble polysaccharide commonly derived from seaweed, is known for its diverse biological activities. Fucoidan from Costaria costata (FCC) suppresses lipopolysaccharide (LPS)-induced sepsis and lung inflammation by inhibiting dendritic cell (DC) activation. In this study, we investigated the anti-inflammatory effect of FCC in a mouse model of ulcerative colitis (UC), which is a chronic inflammatory disease of the colon. Orally administered FCC significantly inhibited UC severity induced by dextran sulfate sodium (DSS) intake. In particular, FCC administration decreased the infiltration of T cells and neutrophils into the colon of DSS-treated mice. Furthermore, FCC suppressed the DSS-induced production of interferon-gamma (IFN-γ) and interleukin 17 (IL-17) in colonic T cells. However, FCC did not directly suppress IFN-γ and IL-17 production in CD4 T cells. FCC administration also reduced the DSS-induced increase in the number of DCs in mesenteric lymph node (mLN). Additionally, FCC suppressed DSS-induced upregulation of co-stimulators and major histocompatibility complex (MHC) molecules in mLN DCs. FCC also inhibited LPS-induced DC activation, which resulted in reduced T cell proliferation and differentiation. These findings demonstrate that oral FCC alleviates UC by targeting DCs and T cell activity, thereby highlighting its potential as a therapeutic agent for intestinal inflammation. |
| title | Fucoidan from Costaria costata alleviated dextran sulfate sodium-induced ulcerative colitis by suppressing dendritic cell activation. |
| topic | Animals Polysaccharides Dendritic Cells Colitis, Ulcerative Dextran Sulfate Mice Disease Models, Animal Male Phaeophyceae Cell Proliferation |
| url | https://pubmed.ncbi.nlm.nih.gov/41539506/ |