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Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.

Fuente: PubMed

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Bibliographic Details
Main Authors:	Fang, Zhangyun, Zhan, Shuai, Mao, Churu, Zhang, Ningjing, Zhao, Xiaofeng, Huang, Yun, Ding, Wanjing, Ma, Zhongjun
Format:	Artículo científico
Language:	en
Published:	European journal of medicinal chemistry 2026
Subjects:	Bromodomain Containing Proteins Humans Animals Cell Cycle Proteins Antineoplastic Agents Colorectal Neoplasms Transcription Factors Mice Administration, Oral Cell Proliferation Structure-Activity Relationship Drug Discovery Pyridones Drug Screening Assays, Antitumor Dose-Response Relationship, Drug Molecular Structure Biological Availability Mice, Nude Neoplasms, Experimental
Online Access:	Acceder al recurso
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