Copertina

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.

Fuente: PubMed

Salvato in:

Dettagli Bibliografici
Autori principali:	Fang, Zhangyun, Zhan, Shuai, Mao, Churu, Zhang, Ningjing, Zhao, Xiaofeng, Huang, Yun, Ding, Wanjing, Ma, Zhongjun
Natura:	Artículo científico
Lingua:	en
Pubblicazione:	European journal of medicinal chemistry 2026
Soggetti:	Bromodomain Containing Proteins Humans Animals Cell Cycle Proteins Antineoplastic Agents Colorectal Neoplasms Transcription Factors Mice Administration, Oral Cell Proliferation Structure-Activity Relationship Drug Discovery Pyridones Drug Screening Assays, Antitumor Dose-Response Relationship, Drug Molecular Structure Biological Availability Mice, Nude Neoplasms, Experimental
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
di: Cao, Yin, et al.
Pubblicazione: (2025)

Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
di: Mao, Churu, et al.
Pubblicazione: (2024)

Activation of the γ-secretase/NICD-PXR/Notch pathway induces Taxol resistance in triple-negative breast cancer.
di: Wang, Zuo-Jun, et al.
Pubblicazione: (2024)

Oxalicpyridones A-D, 2-pyridone alkaloids from a marine-derived fungus Penicillium oxalicum suppressing proliferation and metastasis against small cell lung cancer.
di: Chen, Xiangliu, et al.
Pubblicazione: (2026)

Discovery of novel thiosemicarbazone dimers as effective inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer therapy.
di: Wang, Lijun, et al.
Pubblicazione: (2026)

Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
di: Qiao, Ziwen, et al.
Pubblicazione: (2025)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
di: Du, Lin, et al.
Pubblicazione: (2025)

Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1.
di: Tao, Xiaoyu, et al.
Pubblicazione: (2025)

Preparation of mitochondria-targeted camptothecin derivatives for the imaging and antiproliferation of colorectal cancer.
di: Xu, Chenmeng, et al.
Pubblicazione: (2025)

Synthesis of mitochondria-targeted podophyllotoxin derivatives for the imaging and antiproliferation of liver cancer.
di: Xu, Chenmeng, et al.
Pubblicazione: (2026)

Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
di: Yu, Jing, et al.
Pubblicazione: (2026)

Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue.
di: Zhao, Xiuhe, et al.
Pubblicazione: (2024)

Cereblon upregulation overcomes thalidomide resistance in multiple myeloma through mitochondrial functional reprogramming.
di: Marquez, Jubert, et al.
Pubblicazione: (2026)

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
di: Chen, Xiaohui, et al.
Pubblicazione: (2025)

Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining.
di: Jayaraman, Vennila, et al.
Pubblicazione: (2025)

Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi.
di: Luu, Phuong Vu, et al.
Pubblicazione: (2026)

Epac (RAPGEF3) promotes betaglycan expression to mediate ciprofloxacin-induced suppression of cancer cell migration and metastasis: Mechanistic insights and drug repurposing potential.
di: Liu, Hui-Pu, et al.
Pubblicazione: (2025)

Ircindrimanes A-I, nine undescribed meroterpenoids with cytotoxic activities from the marine sponge Ircinia sp.
di: Zhang, Wenjie, et al.
Pubblicazione: (2025)

Pyrimidine Nucleosides, Benzoic Acid Derivative, and Bipyridine From the Marine-Derived Streptomyces Sp. DS52.
di: Xia, Meng-de, et al.
Pubblicazione: (2025)

Tumor Microenvironment-Responsive Multinucleated Nanocomplexes Loaded with Carbon Dots for Combined Photothermal/Chemodynamic Therapy of Breast Cancer.
di: Zhu, Zihan, et al.
Pubblicazione: (2025)

Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity.
di: Liu, Xiao-Mei, et al.
Pubblicazione: (2026)

Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.
di: Xu, Fuju, et al.
Pubblicazione: (2025)

The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from on Human Colon Cancer HCT116 Cells.
di: Zhang, Yuebin, et al.
Pubblicazione: (2024)

Preliminary Insights Into the Combined Antitumor Efficacy of Onco-VV-TT and Natural Killer Cells in Glioblastoma.
di: Mirbahari, Seyedeh Nasim, et al.
Pubblicazione: (2026)

Cytotoxicity, apoptosis, molecular docking, and molecular dynamics study of novel compounds of Sulfamide derivatives coupled with DHP scaffolds as potent inhibitors of the MCF-7, A549, SKOV-3, and EA. yh926 carcinoma cells.
di: Abdulrasool, Amjed, et al.
Pubblicazione: (2026)

Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
di: Mao, Churu, et al.
Pubblicazione: (2026)

Marine-Derived Bromotyrosine Alkaloids as Potent hCYP1B1 Inhibitors to Overcome Paclitaxel Resistance.
di: Xu, Quan, et al.
Pubblicazione: (2026)

Total Synthesis of Nocarterphenyl A, 2-Dehydroxymethylnocarterphenyl A and Nocarterphenyl D Produced by Marine spp.
di: Xu, Quan, et al.
Pubblicazione: (2025)

BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53.
di: Wang, Qingwei, et al.
Pubblicazione: (2026)

Total syntheses of Kavaratamide A and 5--Kavaratamide A.
di: Ren, Tieshun, et al.
Pubblicazione: (2025)

FL496, an FL118-derived small molecule, induces growth inhibition, senescence, and apoptosis of malignant pleural mesothelioma (MPM) cells, and exhibits anti-MPM tumor efficacy strikingly superior to the pemetrexed-cisplatin combination.
di: Aljahdali, Ieman A M, et al.
Pubblicazione: (2025)

Undescribed alkaloids, peptides and polyketides from marine sediment-derived fungus Aspergillus terreus PPS1.
di: Zheng, Yao-Yao, et al.
Pubblicazione: (2025)

Water-Dispersible Plasmonic Gold Nanoparticle Vesicle as a Drug Delivery Carrier for Cancer Therapy.
di: Wei, Jinjian, et al.
Pubblicazione: (2026)

PSPC1 knockout promotes radiosensitivity, inhibits EMT, and metastasis of nasopharyngeal carcinoma cells.
di: He, Huocong, et al.
Pubblicazione: (2025)

NQO1-Activatable Circular Antisense Oligonucleotides for Tumor-Cell-Specific Survivin Gene Silencing and Antitumor Therapy.
di: Zhao, Xiaoran, et al.
Pubblicazione: (2025)

Immunocompetent tumor-on-a-chip: A translational tool for drug screening and cancer therapy.
di: Liang, Anqi, et al.
Pubblicazione: (2025)

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
di: Mzoughi, Slim, et al.
Pubblicazione: (2025)

Synergistic induction of immunogenic cell death and tumor microenvironment remodeling by biotinylated marine polysaccharide nanoparticles for enhanced colorectal cancer therapy.
di: Wang, Hui, et al.
Pubblicazione: (2026)

Metabolic Blockade-Based Genome Mining of SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds.
di: Li, Kunlong, et al.
Pubblicazione: (2025)

Integrating experimental findings and machine learning models to predict the anticancer potential of newly synthesized oversulfated fucoidan.
di: Kocabay, Samet, et al.
Pubblicazione: (2026)