Reviewing Marine Bioactive Compounds From the Red Sea: Advancing Therapeutic Applications While Navigating Translational and Conservation Challenges.
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| Natura: | Artículo científico |
| Lingua: | en |
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Chemistry & biodiversity
2026
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| _version_ | 1868266097667473409 |
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| author | Hawwal, Mohammed F Sayyed, Nadeem Fantoukh, Omer I AlHamoud, Gadah A Ahmed, Sarfaraz Alqasoumi, Saleh I Alam, Perwez |
| author_facet | Hawwal, Mohammed F Sayyed, Nadeem Fantoukh, Omer I AlHamoud, Gadah A Ahmed, Sarfaraz Alqasoumi, Saleh I Alam, Perwez Hawwal, Mohammed F Sayyed, Nadeem Fantoukh, Omer I AlHamoud, Gadah A Ahmed, Sarfaraz Alqasoumi, Saleh I Alam, Perwez |
| collection | PubMed - marine biology |
| contents | Reviewing Marine Bioactive Compounds From the Red Sea: Advancing Therapeutic Applications While Navigating Translational and Conservation Challenges. Hawwal, Mohammed F Sayyed, Nadeem Fantoukh, Omer I AlHamoud, Gadah A Ahmed, Sarfaraz Alqasoumi, Saleh I Alam, Perwez Animals Indian Ocean Humans Biological Products Aquatic Organisms Antineoplastic Agents Drug Discovery Microalgae Conservation of Natural Resources The Red Sea, a biologically rich marine ecosystem, is a promising source of novel bioactive compounds with significant therapeutic potential. This review analyzes a decade of research on the isolation, characterization, and biological activities of compounds obtained from sponges, corals, microalgae, seaweeds, marine fish, and microorganisms. These bioactive molecules, including alkaloids, glycosides, terpenes, and peptides, exhibit antimicrobial, anticancer, anti-inflammatory, and neuroprotective properties. Various extraction techniques, ranging from traditional solvent extraction to advanced methods such as supercritical fluid and ultrasound-assisted extraction, aid in their isolation. Meanwhile, chromatographic purification and bioassay-guided fractionation enhance their identification. However, challenges such as limited availability, complex extraction processes, and regulatory constraints hinder the clinical translation of these technologies. Addressing these barriers requires innovative extraction strategies, advanced characterization techniques, and interdisciplinary approaches that integrate marine biology with emerging technologies, such as deep learning. Future research should focus on exploring molecular interactions within coral reef ecosystems, unraveling marine bacterial diversity, and implementing conservation strategies to protect the Red Sea's unique biodiversity while accelerating drug discovery. |
| format | Artículo científico |
| id | pubmed_41563944 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Reviewing Marine Bioactive Compounds From the Red Sea: Advancing Therapeutic Applications While Navigating Translational and Conservation Challenges. Hawwal, Mohammed F Sayyed, Nadeem Fantoukh, Omer I AlHamoud, Gadah A Ahmed, Sarfaraz Alqasoumi, Saleh I Alam, Perwez Animals Indian Ocean Humans Biological Products Aquatic Organisms Antineoplastic Agents Drug Discovery Microalgae Conservation of Natural Resources Reviewing Marine Bioactive Compounds From the Red Sea: Advancing Therapeutic Applications While Navigating Translational and Conservation Challenges. Hawwal, Mohammed F Sayyed, Nadeem Fantoukh, Omer I AlHamoud, Gadah A Ahmed, Sarfaraz Alqasoumi, Saleh I Alam, Perwez Animals Indian Ocean Humans Biological Products Aquatic Organisms Antineoplastic Agents Drug Discovery Microalgae Conservation of Natural Resources The Red Sea, a biologically rich marine ecosystem, is a promising source of novel bioactive compounds with significant therapeutic potential. This review analyzes a decade of research on the isolation, characterization, and biological activities of compounds obtained from sponges, corals, microalgae, seaweeds, marine fish, and microorganisms. These bioactive molecules, including alkaloids, glycosides, terpenes, and peptides, exhibit antimicrobial, anticancer, anti-inflammatory, and neuroprotective properties. Various extraction techniques, ranging from traditional solvent extraction to advanced methods such as supercritical fluid and ultrasound-assisted extraction, aid in their isolation. Meanwhile, chromatographic purification and bioassay-guided fractionation enhance their identification. However, challenges such as limited availability, complex extraction processes, and regulatory constraints hinder the clinical translation of these technologies. Addressing these barriers requires innovative extraction strategies, advanced characterization techniques, and interdisciplinary approaches that integrate marine biology with emerging technologies, such as deep learning. Future research should focus on exploring molecular interactions within coral reef ecosystems, unraveling marine bacterial diversity, and implementing conservation strategies to protect the Red Sea's unique biodiversity while accelerating drug discovery. |
| title | Reviewing Marine Bioactive Compounds From the Red Sea: Advancing Therapeutic Applications While Navigating Translational and Conservation Challenges. |
| topic | Animals Indian Ocean Humans Biological Products Aquatic Organisms Antineoplastic Agents Drug Discovery Microalgae Conservation of Natural Resources |
| url | https://pubmed.ncbi.nlm.nih.gov/41563944/ |