extract in wound healing: exploring its potential and comparison with conventional topical therapies.
Fuente:
PubMed
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Cutaneous and ocular toxicology
2026
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266095193882624 |
|---|---|
| author | Akın, Ibrahim Ozturan, Yalcin Alper Cengiz, Zeynep Erdogan, Omer Epıkmen, Erkmen Tugrul Ipek, Emrah Canlı, Kerem Benek, Atakan Cevik, Ozge |
| author_facet | Akın, Ibrahim Ozturan, Yalcin Alper Cengiz, Zeynep Erdogan, Omer Epıkmen, Erkmen Tugrul Ipek, Emrah Canlı, Kerem Benek, Atakan Cevik, Ozge Akın, Ibrahim Ozturan, Yalcin Alper Cengiz, Zeynep Erdogan, Omer Epıkmen, Erkmen Tugrul Ipek, Emrah Canlı, Kerem Benek, Atakan Cevik, Ozge |
| collection | PubMed - marine biology |
| contents | extract in wound healing: exploring its potential and comparison with conventional topical therapies. Akın, Ibrahim Ozturan, Yalcin Alper Cengiz, Zeynep Erdogan, Omer Epıkmen, Erkmen Tugrul Ipek, Emrah Canlı, Kerem Benek, Atakan Cevik, Ozge Animals Male Alismatales Wound Healing Plant Extracts Mice, Inbred BALB C Mice Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Plant Leaves Oxidative Stress Skin Centella Alginates Administration, Topical Hydrogels Triterpenes Wound healing is a complex, multistage process regulated by inflammatory, oxidative, regenerative processes, and marine-derived compounds are increasingly recognized for their therapeutic potential. This study evaluated the wound-healing efficacy of an aqueous (PO) leaf extract in standardized full-thickness mice wounds, compared with alginate hydrogel (AH), fusidic acid + cream (FM), and untreated controls (NC). Ninety-six (6-8-week-old) male BALB/c mice were randomized into four groups; four 4-mm dorsal wounds were created on each animal, and treatments were applied topically once daily for 14 days. Wound healing was assessed by planimetric wound area measurements, histological evaluations, biochemical analysis of oxidative stress, inflammatory biomarkers and growth factors, hydroxyproline levels, and gene expression analysis of MMP-2 and MMP-9. Application of PO extract significantly reduced wound areas from day 3 onward compared with NC and FM groups, with effects comparable to AH group by day 14. PO treatment increased epithelialization, fibroblast growth factor, and hydroxyproline levels, while reducing macrophage infiltration, oxidative stress, and inflammatory cytokines. Genomic analyses further indicated that topical PO extract significantly downregulated the expression of MMP-2 and MMP-9, supporting balanced extracellular matrix remodeling. PO extract promoted wound healing comparable to AH and superior to FM treatment, providing the first in vivo evidence for as a promising marine-derived therapeutic candidate for wound care. |
| format | Artículo científico |
| id | pubmed_41569283 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Cutaneous and ocular toxicology |
| record_format | pubmed |
| spellingShingle | extract in wound healing: exploring its potential and comparison with conventional topical therapies. Akın, Ibrahim Ozturan, Yalcin Alper Cengiz, Zeynep Erdogan, Omer Epıkmen, Erkmen Tugrul Ipek, Emrah Canlı, Kerem Benek, Atakan Cevik, Ozge Animals Male Alismatales Wound Healing Plant Extracts Mice, Inbred BALB C Mice Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Plant Leaves Oxidative Stress Skin Centella Alginates Administration, Topical Hydrogels Triterpenes extract in wound healing: exploring its potential and comparison with conventional topical therapies. Akın, Ibrahim Ozturan, Yalcin Alper Cengiz, Zeynep Erdogan, Omer Epıkmen, Erkmen Tugrul Ipek, Emrah Canlı, Kerem Benek, Atakan Cevik, Ozge Animals Male Alismatales Wound Healing Plant Extracts Mice, Inbred BALB C Mice Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Plant Leaves Oxidative Stress Skin Centella Alginates Administration, Topical Hydrogels Triterpenes Wound healing is a complex, multistage process regulated by inflammatory, oxidative, regenerative processes, and marine-derived compounds are increasingly recognized for their therapeutic potential. This study evaluated the wound-healing efficacy of an aqueous (PO) leaf extract in standardized full-thickness mice wounds, compared with alginate hydrogel (AH), fusidic acid + cream (FM), and untreated controls (NC). Ninety-six (6-8-week-old) male BALB/c mice were randomized into four groups; four 4-mm dorsal wounds were created on each animal, and treatments were applied topically once daily for 14 days. Wound healing was assessed by planimetric wound area measurements, histological evaluations, biochemical analysis of oxidative stress, inflammatory biomarkers and growth factors, hydroxyproline levels, and gene expression analysis of MMP-2 and MMP-9. Application of PO extract significantly reduced wound areas from day 3 onward compared with NC and FM groups, with effects comparable to AH group by day 14. PO treatment increased epithelialization, fibroblast growth factor, and hydroxyproline levels, while reducing macrophage infiltration, oxidative stress, and inflammatory cytokines. Genomic analyses further indicated that topical PO extract significantly downregulated the expression of MMP-2 and MMP-9, supporting balanced extracellular matrix remodeling. PO extract promoted wound healing comparable to AH and superior to FM treatment, providing the first in vivo evidence for as a promising marine-derived therapeutic candidate for wound care. |
| title | extract in wound healing: exploring its potential and comparison with conventional topical therapies. |
| topic | Animals Male Alismatales Wound Healing Plant Extracts Mice, Inbred BALB C Mice Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Plant Leaves Oxidative Stress Skin Centella Alginates Administration, Topical Hydrogels Triterpenes |
| url | https://pubmed.ncbi.nlm.nih.gov/41569283/ |