:: Library Catalog

Cover Image

Saved in:

Bibliographic Details
Main Authors:	Mao, Churu, Zhan, Shuai, Fang, Zhangyun, Fang, Jiebin, Huang, Yun, Ding, Wanjing, Ma, Zhongjun
Format:	Artículo científico
Language:	en
Published:	Journal of medicinal chemistry 2026
Subjects:	rho-Associated Kinases Animals Dermatitis, Atopic Drug Design Mice Protein Kinase Inhibitors Humans Structure-Activity Relationship
Online Access:	https://pubmed.ncbi.nlm.nih.gov/41574563/
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
by: Mao, Churu, et al.
Published: (2024)

Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
by: Bourg, Stéphane, et al.
Published: (2026)

Degradation of NLRP3 by selective ROCK2 inhibitor alleviates acute lung injury.
by: Zhan, Shuai, et al.
Published: (2025)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
by: Du, Lin, et al.
Published: (2025)

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
by: Chen, Xiaohui, et al.
Published: (2025)

Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition.
by: Tisseur, Lhana, et al.
Published: (2025)

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.
by: Cao, Yin, et al.
Published: (2025)

Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.
by: Malosse, Killian, et al.
Published: (2025)

DGMM: A Deep Learning-Genetic Algorithm Framework for Efficient Lead Optimization in Drug Discovery.
by: Fang, Jiebin, et al.
Published: (2025)

A mechanosensitive circuit of FAK, ROCK, and ERK controls biomineral growth and morphology in the sea urchin embryo.
by: Layous, Majed, et al.
Published: (2025)

Brianolide from Attenuates Atopic Dermatitis-like Skin Lesions by Regulating the NFκB and MAPK Pathways.
by: Wang, Chia-Chen, et al.
Published: (2025)

MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication.
by: Huang, Yuhan, et al.
Published: (2026)

Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
by: Yasir, Muhammad, et al.
Published: (2024)

Sun Exposure and Skin Cancer: A Narrative Review of Risk Factors, Prevention Behaviors, and Emerging Therapeutic Approaches
by: Silva, Luiz Felipe Rodrigues, et al.
Published: (2026)

A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.
by: Wisessaowapak, Churaibhon, et al.
Published: (2026)

Discovery of an orally bioavailable pyridone-based BRD4 inhibitor with potent antitumor efficacy in colorectal cancer.
by: Fang, Zhangyun, et al.
Published: (2026)

RNF34 negatively regulates innate immunity via ubiquitin-mediated TAK1 degradation in miiuy croaker (Miichthysmiiuy).
by: Dong, Wenjing, et al.
Published: (2025)

Primary Cilia-Mediated Hedgehog Signaling Regulates Cell Fate During ER Stress-Induced Life or Death Decisions.
by: Xu, Jia, et al.
Published: (2025)

Structure-function relationship of the brown seaweed Undaria pinnatifida laminaran: Protein kinase C-mediated mucus secretion and gut barrier restoration.
by: Cheong, Kit-Leong, et al.
Published: (2025)

Repurposing Lamivudine: A novel therapeutic strategy for ischemic stroke targeting the glycolytic enzyme Pgk1.
by: Liu, Jingjing, et al.
Published: (2026)

Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
by: Wicaksono, Danar, et al.
Published: (2024)

Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity.
by: Lai, Wencong, et al.
Published: (2026)

Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology.
by: Lohnes, Benedikt Jakob, et al.
Published: (2026)

BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53.
by: Wang, Qingwei, et al.
Published: (2026)

BIT1 as an Effector of EGFR-TKI-induced Apoptosis TLE1 Inhibition in Lung Adenocarcinoma Cells.
by: Dela Cruz, Ma Carmela, et al.
Published: (2026)

New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302.
by: Pham, Giang Nam, et al.
Published: (2024)

protein kinase MAK phosphorylates FAP256/CEP104 and regulates axonemal microtubule assembly.
by: Zhang, Yi, et al.
Published: (2025)

Crustacean Protein Kinases A and C: Bioinformatic Characterization in Decapods and Other Non-Model Organisms.
by: Head, Talia B, et al.
Published: (2025)

Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress.
by: Ye, Haicheng, et al.
Published: (2025)

Computational insights into marine natural products as potential antidiabetic agents targeting the SIK2 protein kinase domain.
by: Heyram, K, et al.
Published: (2024)

Prkra dimer senses double-stranded RNAs to dictate global translation efficiency.
by: Lu, Tong, et al.
Published: (2025)

Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters.
by: Wang, Chaogang, et al.
Published: (2024)

A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways.
by: Chen, Hanbin, et al.
Published: (2025)

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.
by: Lu, Long-Feng, et al.
Published: (2026)

Novel peptide inhibitor of matrix Metalloproteinases-1 from pufferfish skin collagen hydrolysates and its potential Photoprotective activity via the MAPK/AP-1 signaling pathway.
by: Chen, Bei, et al.
Published: (2025)

A Crystal Structure of Pro c 2 Provides Insights into Cross-Reactivity of Aquatic Allergens from the Phosphagen Kinase Family.
by: Yang, Yang, et al.
Published: (2024)

Structure-Directed Optimization of Ebselen Derivatives as Potent NDM-1 Inhibitors Reverses Meropenem Resistance.
by: Guo, Yan, et al.
Published: (2025)

Traducción-adaptación transcultural al español del cuestionario Infants Dermatology Quality of Life para niños menores de cuatro años con dermatitis atópica
by: Carmen Alexandra Maza-De Franco
Published: (2016)

Starfish-Derived Extracts Enhance Mitophagy and Suppress Senescence-Associated Markers in Human Dermal Fibroblasts.
by: Lee, Hyun Jung, et al.
Published: (2025)

KiNext: a portable and scalable workflow for the identification and classification of protein kinases.
by: Hellec, Elisabeth, et al.
Published: (2024)