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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Sleep medicine reviews
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41576720/ |
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Table of Contents:
- Advances in sleep research based on the Caenorhabditis elegans: an intestinal microbiota perspective and cutting-edge technology applications. Zhang, Wan-Qi Li, Xiao-Lin Xu, Rui-Peng Li, Yu-Long Hu, Peng-Fei Wong, Ka-Hing Lin, Zhong-Yang Yang, Qiong-Qiong Zhang, Bo-Bo Animals Caenorhabditis elegans Sleep Gastrointestinal Microbiome Humans Sleep Wake Disorders Brain Sleep disorders affect approximately 27 % of the global population, driving non-pharmacological research on gut-brain axis regulation. Understanding sleep mechanisms is crucial, given its profound impact on health and disease. Caenorhabditis elegans (C. elegans) offers a powerful model for dissecting fundamental sleep processes, owing to its compact and fully mapped nervous system, genetic tractability, and suitability for high-throughput screening. This review leverages C. elegans integrated with gene editing, high-throughput behavioral phenotyping, and calcium imaging to dissect gut microbiota's role in sleep modulation. We explore how microbial metabolites regulate sleep via gut-brain pathways and summarize conserved sleep-related molecular mechanisms. The purpose of this review is to decode gut-brain-sleep axis interactions, offering novel mechanistic insights into sleep disorder pathophysiology.