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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of applied toxicology : JAT
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41578638/ |
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Table of Contents:
- Vitellogenin as a Basic Biomarker: Endocrine Disruptor Effects of Sodium Pyrithione on Zebrafish (Danio Rerio). Şemsi, Rabia Günal, Aysel Çağlan Tural, Rabia Dinçel, Aylin Sepici Erkoç, Figen In recent years, one of the most striking consequences of overpopulation and consumption activities worldwide has been the rapid increase in environmental pollutants. Sodium pyrithione (NaPT) is an organosulfur compound commonly used for its antimicrobial and antifungal properties in industrial and personal care products. The primary objective of this study was to determine the impact of NaPT exposure on whole-body vitellogenin (Vtg) levels in adult male zebrafish, a highly relevant model for toxicological studies. As Vtg functions as a key estrogen-responsive biomarker, its induction serves as a critical indicator for assessing endocrine disruption, thereby justifying its selection as the primary endpoint. The adaptation period completed, stocked zebrafish were transferred to experimental aquariums and exposed to 1 and 5 μg/L concentrations of NaPT for 24, 72, 96 h, and 7 days. Commercial ELISA kits determined Vtg levels. The whole-body zebrafish Vtg analysis revealed that Vtg levels were increased at all time intervals, regardless of dose differences, compared to the control group (p