Marine-derived antimicrobial peptides (AMPs): Blue biotechnological assets for sustainable healthcare and circular bioeconomy.
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| Format: | Artículo científico |
| Sprache: | en |
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Advances in protein chemistry and structural biology
2026
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| author | Selvaraj, Chandrabose Desai, Deepali Santos-Villalobos, Sergio de Los Jayaprakashvel, Mani Muthezhilan, Radhakrishnan Singh, Sanjeev Kumar |
| author_facet | Selvaraj, Chandrabose Desai, Deepali Santos-Villalobos, Sergio de Los Jayaprakashvel, Mani Muthezhilan, Radhakrishnan Singh, Sanjeev Kumar Selvaraj, Chandrabose Desai, Deepali Santos-Villalobos, Sergio de Los Jayaprakashvel, Mani Muthezhilan, Radhakrishnan Singh, Sanjeev Kumar |
| collection | PubMed - marine biology |
| contents | Marine-derived antimicrobial peptides (AMPs): Blue biotechnological assets for sustainable healthcare and circular bioeconomy. Selvaraj, Chandrabose Desai, Deepali Santos-Villalobos, Sergio de Los Jayaprakashvel, Mani Muthezhilan, Radhakrishnan Singh, Sanjeev Kumar Antimicrobial Peptides Biotechnology Aquatic Organisms Animals Humans The global antimicrobial resistance (AMR) crisis drives the demand for novel therapeutics, positioning marine-derived antimicrobial peptides (AMPs) as sustainable alternatives with unique structural and functional advantages. These cationic, amphipathic molecules, from the source of diverse marine organisms, such as invertebrates, extremophiles, and cyanobacteria, exhibit broad-spectrum activity against drug-resistant pathogens through mechanisms like membrane disruption and immunomodulation. Their low resistance propensity and multifunctional bioactivity (eg., antioxidant, antimicrobial, anticancer) underscore therapeutic potential beyond the conventional antibiotics. Advances in genomic and metagenomic tools, machine learning, and synthetic biology are revolutionizing AMP discovery, enabling targeted mining of marine biodiversity and peptide optimization for enhanced stability and specificity. Biotechnological innovations support scalable production through heterologous expression and marine biomass valorization, which aligns with the principles of the circular economy. Marine-sourced AMPs demonstrate transformative applications across various healthcare, aquaculture, food safety, and environmental remediation, that majorly reduce the dependence on synthetic chemicals. Their integration into blue bioeconomy frameworks is promoting sustainable bio-prospects, marine ecosystem conservation, and progress towards the United Nations Sustainable Development Goals. This review narrates the collective research and also addresses the critical challenges, including production scalability and regulatory frameworks, to outline a clear pathway for the marine sourced AMP commercialization. By bridging the antimicrobial innovation with circular biotechnology, marine-sourced AMPs are exemplifying the ocean's role as a reservoir of sustainable solutions for global health and bioeconomic resilience. |
| format | Artículo científico |
| id | pubmed_41581932 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Advances in protein chemistry and structural biology |
| record_format | pubmed |
| spellingShingle | Marine-derived antimicrobial peptides (AMPs): Blue biotechnological assets for sustainable healthcare and circular bioeconomy. Selvaraj, Chandrabose Desai, Deepali Santos-Villalobos, Sergio de Los Jayaprakashvel, Mani Muthezhilan, Radhakrishnan Singh, Sanjeev Kumar Antimicrobial Peptides Biotechnology Aquatic Organisms Animals Humans Marine-derived antimicrobial peptides (AMPs): Blue biotechnological assets for sustainable healthcare and circular bioeconomy. Selvaraj, Chandrabose Desai, Deepali Santos-Villalobos, Sergio de Los Jayaprakashvel, Mani Muthezhilan, Radhakrishnan Singh, Sanjeev Kumar Antimicrobial Peptides Biotechnology Aquatic Organisms Animals Humans The global antimicrobial resistance (AMR) crisis drives the demand for novel therapeutics, positioning marine-derived antimicrobial peptides (AMPs) as sustainable alternatives with unique structural and functional advantages. These cationic, amphipathic molecules, from the source of diverse marine organisms, such as invertebrates, extremophiles, and cyanobacteria, exhibit broad-spectrum activity against drug-resistant pathogens through mechanisms like membrane disruption and immunomodulation. Their low resistance propensity and multifunctional bioactivity (eg., antioxidant, antimicrobial, anticancer) underscore therapeutic potential beyond the conventional antibiotics. Advances in genomic and metagenomic tools, machine learning, and synthetic biology are revolutionizing AMP discovery, enabling targeted mining of marine biodiversity and peptide optimization for enhanced stability and specificity. Biotechnological innovations support scalable production through heterologous expression and marine biomass valorization, which aligns with the principles of the circular economy. Marine-sourced AMPs demonstrate transformative applications across various healthcare, aquaculture, food safety, and environmental remediation, that majorly reduce the dependence on synthetic chemicals. Their integration into blue bioeconomy frameworks is promoting sustainable bio-prospects, marine ecosystem conservation, and progress towards the United Nations Sustainable Development Goals. This review narrates the collective research and also addresses the critical challenges, including production scalability and regulatory frameworks, to outline a clear pathway for the marine sourced AMP commercialization. By bridging the antimicrobial innovation with circular biotechnology, marine-sourced AMPs are exemplifying the ocean's role as a reservoir of sustainable solutions for global health and bioeconomic resilience. |
| title | Marine-derived antimicrobial peptides (AMPs): Blue biotechnological assets for sustainable healthcare and circular bioeconomy. |
| topic | Antimicrobial Peptides Biotechnology Aquatic Organisms Animals Humans |
| url | https://pubmed.ncbi.nlm.nih.gov/41581932/ |