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Main Authors:	Le, Huong-Giang, Huynh, Thi Luu Kim Huong, Huynh, Thanh Hao, Pham, Ngoc-Thac, Peng, Bo-Rong, El-Shazly, Mohamed, Chen, Lo-Yun, Wang, Lung-Shuo, Yen, Pei-Tzu, Lai, Kuei-Hung
Format:	Artículo científico
Language:	en
Published:	The American journal of Chinese medicine 2026
Subjects:	Panax Humans Ginsenosides Fatigue Animals Ethnopharmacology Phytochemicals Phytotherapy Evidence-Based Medicine Medicine, Chinese Traditional Structure-Activity Relationship Drugs, Chinese Herbal
Online Access:	https://pubmed.ncbi.nlm.nih.gov/41582079/
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author	Le, Huong-Giang Huynh, Thi Luu Kim Huong Huynh, Thanh Hao Pham, Ngoc-Thac Peng, Bo-Rong El-Shazly, Mohamed Chen, Lo-Yun Wang, Lung-Shuo Yen, Pei-Tzu Lai, Kuei-Hung
author_facet	Le, Huong-Giang Huynh, Thi Luu Kim Huong Huynh, Thanh Hao Pham, Ngoc-Thac Peng, Bo-Rong El-Shazly, Mohamed Chen, Lo-Yun Wang, Lung-Shuo Yen, Pei-Tzu Lai, Kuei-Hung Le, Huong-Giang Huynh, Thi Luu Kim Huong Huynh, Thanh Hao Pham, Ngoc-Thac Peng, Bo-Rong El-Shazly, Mohamed Chen, Lo-Yun Wang, Lung-Shuo Yen, Pei-Tzu Lai, Kuei-Hung
collection	PubMed - marine biology
contents	Phytochemical Insights into Genus Metabolites: Evidence-Based Fatigue Intervention via Ethnopharmacological and Biomedical Perspectives. Le, Huong-Giang Huynh, Thi Luu Kim Huong Huynh, Thanh Hao Pham, Ngoc-Thac Peng, Bo-Rong El-Shazly, Mohamed Chen, Lo-Yun Wang, Lung-Shuo Yen, Pei-Tzu Lai, Kuei-Hung Panax Humans Ginsenosides Fatigue Animals Ethnopharmacology Phytochemicals Phytotherapy Evidence-Based Medicine Medicine, Chinese Traditional Structure-Activity Relationship Drugs, Chinese Herbal Traditional Chinese Medicine (TCM) has a longstanding history in the treatment of fatigue-related conditions, and is increasingly recognized as a foundation for novel therapeutic approaches. The genus, extensively utilized in the fundamental TCM principles to enhance vitality, modulate immune function, and stimulate Yang energy, is a key resource in managing both physiological and pathological fatigue. This study provides a comprehensive synthesis of recent advancements in plant-derived metabolites from various species with an emphasis on their structural diversity and structure-activity relationships. Notably, this represents the first systematic exploration of metabolites with potential antifatigue effects. A systematic literature review was conducted using major scientific databases such as PubMed, Google Scholar, and ScienceDirect. The search query "(scientific name of herbal medicine in the genus) AND ("antifatigue")" was employed. Additionally, classical herbals, botanical literature, and pharmacopoeias were reviewed to contextualize the findings. Comprehensive analysis of 105 studies elucidated 16 predominant metabolites exhibiting antifatigue activity. These metabolites primarily originated from , , and . Ginsenosides Rb1 and Rg1 demonstrated the most substantial pharmacological efficacy in experimental models, in particular by ameliorating metabolic perturbations and mitigating oxidative stress . Clinical trials predominantly relied on subjective patient-reported measures, such as the Multidimensional Fatigue Inventory (MFI) and Visual Analogue Scale (VAS), and yielded largely positive outcomes. These findings substantiate fundamental TCM principles and reinforce the therapeutic potential of species in fatigue management. The integration of traditional knowledge with contemporary biomedical research enhances the understanding and clinical applicability of species in addressing fatigue-related disorders.
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institution	PubMed
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publishDate	2026
publisher	The American journal of Chinese medicine
record_format	pubmed
spellingShingle	Phytochemical Insights into Genus Metabolites: Evidence-Based Fatigue Intervention via Ethnopharmacological and Biomedical Perspectives. Le, Huong-Giang Huynh, Thi Luu Kim Huong Huynh, Thanh Hao Pham, Ngoc-Thac Peng, Bo-Rong El-Shazly, Mohamed Chen, Lo-Yun Wang, Lung-Shuo Yen, Pei-Tzu Lai, Kuei-Hung Panax Humans Ginsenosides Fatigue Animals Ethnopharmacology Phytochemicals Phytotherapy Evidence-Based Medicine Medicine, Chinese Traditional Structure-Activity Relationship Drugs, Chinese Herbal Phytochemical Insights into Genus Metabolites: Evidence-Based Fatigue Intervention via Ethnopharmacological and Biomedical Perspectives. Le, Huong-Giang Huynh, Thi Luu Kim Huong Huynh, Thanh Hao Pham, Ngoc-Thac Peng, Bo-Rong El-Shazly, Mohamed Chen, Lo-Yun Wang, Lung-Shuo Yen, Pei-Tzu Lai, Kuei-Hung Panax Humans Ginsenosides Fatigue Animals Ethnopharmacology Phytochemicals Phytotherapy Evidence-Based Medicine Medicine, Chinese Traditional Structure-Activity Relationship Drugs, Chinese Herbal Traditional Chinese Medicine (TCM) has a longstanding history in the treatment of fatigue-related conditions, and is increasingly recognized as a foundation for novel therapeutic approaches. The genus, extensively utilized in the fundamental TCM principles to enhance vitality, modulate immune function, and stimulate Yang energy, is a key resource in managing both physiological and pathological fatigue. This study provides a comprehensive synthesis of recent advancements in plant-derived metabolites from various species with an emphasis on their structural diversity and structure-activity relationships. Notably, this represents the first systematic exploration of metabolites with potential antifatigue effects. A systematic literature review was conducted using major scientific databases such as PubMed, Google Scholar, and ScienceDirect. The search query "(scientific name of herbal medicine in the genus) AND ("antifatigue")" was employed. Additionally, classical herbals, botanical literature, and pharmacopoeias were reviewed to contextualize the findings. Comprehensive analysis of 105 studies elucidated 16 predominant metabolites exhibiting antifatigue activity. These metabolites primarily originated from , , and . Ginsenosides Rb1 and Rg1 demonstrated the most substantial pharmacological efficacy in experimental models, in particular by ameliorating metabolic perturbations and mitigating oxidative stress . Clinical trials predominantly relied on subjective patient-reported measures, such as the Multidimensional Fatigue Inventory (MFI) and Visual Analogue Scale (VAS), and yielded largely positive outcomes. These findings substantiate fundamental TCM principles and reinforce the therapeutic potential of species in fatigue management. The integration of traditional knowledge with contemporary biomedical research enhances the understanding and clinical applicability of species in addressing fatigue-related disorders.
title	Phytochemical Insights into Genus Metabolites: Evidence-Based Fatigue Intervention via Ethnopharmacological and Biomedical Perspectives.
topic	Panax Humans Ginsenosides Fatigue Animals Ethnopharmacology Phytochemicals Phytotherapy Evidence-Based Medicine Medicine, Chinese Traditional Structure-Activity Relationship Drugs, Chinese Herbal
url	https://pubmed.ncbi.nlm.nih.gov/41582079/

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