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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Organic letters
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41589580/ |
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Table of Contents:
- Shimojilide, a Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium sp. Niiyama, Mizuho Kurisawa, Naoaki Dan, Shingo Suenaga, Kiyotake Cyanobacteria Peptides, Cyclic Lipopeptides Antineoplastic Agents Molecular Structure Drug Screening Assays, Antitumor Humans Cell Proliferation Nuclear Magnetic Resonance, Biomolecular Marine Biology Shimojilide (), a new cyclic lipopeptide, was isolated from a marine cyanobacterium sp. Its structure was elucidated by NMR and chemical derivatization, revealing a peptide-polyketide hybrid with a skipped diene and β-branched methyl group. Shimojilide () exhibited potent and selective antiproliferative activity with a unique JFCR39 fingerprint that poorly correlates with those of known anticancer agents, suggesting a distinct mechanism of action. Shimojilide () represents a promising lead for anticancer drug discovery.