Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Strain.
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| Autores principales: | , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Marine drugs
2025
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| _version_ | 1868266095164522497 |
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| author | Yan, Yunchen Li, Zhiting Li, Hongcheng Sun, Junpeng Li, Wenli Xiao, Fei |
| author_facet | Yan, Yunchen Li, Zhiting Li, Hongcheng Sun, Junpeng Li, Wenli Xiao, Fei Yan, Yunchen Li, Zhiting Li, Hongcheng Sun, Junpeng Li, Wenli Xiao, Fei |
| collection | PubMed - marine biology |
| contents | Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Strain. Yan, Yunchen Li, Zhiting Li, Hongcheng Sun, Junpeng Li, Wenli Xiao, Fei Halomonas Indoles Microbial Sensitivity Tests Staphylococcus aureus Anti-Infective Agents Fusarium Anti-Bacterial Agents Molecular Structure Mining bioactive secondary metabolites from microorganisms originating from deep-sea cold seep holds significant potential for discovering novel drug lead compounds. In this study, three known indole derivatives (-) were isolated from cold-seep-derived OUCLQ22-B7. Subsequently, two-new indole dimers, meribisindole A () and meribisindole B (), with nine known metabolites (-) were obtained via indole precursor feeding strategy. The structure of these compounds was elucidated via a combination of spectroscopic methods and circular dichroism (CD) measurement. Antimicrobial assays revealed that compounds , and exhibited potent inhibitory activity against CICC 41029 with minimal inhibitory concentrations (MICs) of 0.39-12.5 μg/mL, and compound showed significant growth inhibition against CCARM 3090 with MIC value at 0.098 μg/mL. |
| format | Artículo científico |
| id | pubmed_41590714 |
| institution | PubMed |
| language | en |
| publishDate | 2025 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Strain. Yan, Yunchen Li, Zhiting Li, Hongcheng Sun, Junpeng Li, Wenli Xiao, Fei Halomonas Indoles Microbial Sensitivity Tests Staphylococcus aureus Anti-Infective Agents Fusarium Anti-Bacterial Agents Molecular Structure Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Strain. Yan, Yunchen Li, Zhiting Li, Hongcheng Sun, Junpeng Li, Wenli Xiao, Fei Halomonas Indoles Microbial Sensitivity Tests Staphylococcus aureus Anti-Infective Agents Fusarium Anti-Bacterial Agents Molecular Structure Mining bioactive secondary metabolites from microorganisms originating from deep-sea cold seep holds significant potential for discovering novel drug lead compounds. In this study, three known indole derivatives (-) were isolated from cold-seep-derived OUCLQ22-B7. Subsequently, two-new indole dimers, meribisindole A () and meribisindole B (), with nine known metabolites (-) were obtained via indole precursor feeding strategy. The structure of these compounds was elucidated via a combination of spectroscopic methods and circular dichroism (CD) measurement. Antimicrobial assays revealed that compounds , and exhibited potent inhibitory activity against CICC 41029 with minimal inhibitory concentrations (MICs) of 0.39-12.5 μg/mL, and compound showed significant growth inhibition against CCARM 3090 with MIC value at 0.098 μg/mL. |
| title | Discovery of Antimicrobial Oligoindoles from a Cold-Seep-Derived Strain. |
| topic | Halomonas Indoles Microbial Sensitivity Tests Staphylococcus aureus Anti-Infective Agents Fusarium Anti-Bacterial Agents Molecular Structure |
| url | https://pubmed.ncbi.nlm.nih.gov/41590714/ |