Fucoidan Extracted from Ameliorates Colitis-Associated Neuroinflammation and Anxiety-like Behavior in Adult C57BL/6 Mice.
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| Natura: | Artículo científico |
| Lingua: | en |
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Marine drugs
2026
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| author | Song, Xiaoyu Li, Na Li, Xiujie Yuan, Bo Zhang, Xuan Li, Sheng Yang, Xiaojing Qi, Bing Yin, Shixuan Li, Chunxue Huang, Yangting Zhang, Ben Guo, Yanjie Zhao, Jie Wu, Xuefei |
| author_facet | Song, Xiaoyu Li, Na Li, Xiujie Yuan, Bo Zhang, Xuan Li, Sheng Yang, Xiaojing Qi, Bing Yin, Shixuan Li, Chunxue Huang, Yangting Zhang, Ben Guo, Yanjie Zhao, Jie Wu, Xuefei Song, Xiaoyu Li, Na Li, Xiujie Yuan, Bo Zhang, Xuan Li, Sheng Yang, Xiaojing Qi, Bing Yin, Shixuan Li, Chunxue Huang, Yangting Zhang, Ben Guo, Yanjie Zhao, Jie Wu, Xuefei |
| collection | PubMed - marine biology |
| contents | Fucoidan Extracted from Ameliorates Colitis-Associated Neuroinflammation and Anxiety-like Behavior in Adult C57BL/6 Mice. Song, Xiaoyu Li, Na Li, Xiujie Yuan, Bo Zhang, Xuan Li, Sheng Yang, Xiaojing Qi, Bing Yin, Shixuan Li, Chunxue Huang, Yangting Zhang, Ben Guo, Yanjie Zhao, Jie Wu, Xuefei Animals Polysaccharides Mice Fucus Mice, Inbred C57BL Anxiety Male Disease Models, Animal Neuroinflammatory Diseases Neuroprotective Agents Colitis, Ulcerative Colitis Brain Anti-Inflammatory Agents Microglia Behavior, Animal Dextran Sulfate Blood-Brain Barrier Fucoidan, a complex sulfated polysaccharide derived from marine brown seaweeds, exhibits broad biological activities, including anticoagulant, antitumor, antiviral, anti-inflammatory and lipid-lowering effects. Fucoidan confers neuroprotection in animal models of a broad spectrum of brain disorders such as Parkinson's disease (PD) and depression. However, the effect of fucoidan on gut-derived neuroinflammation and associated behavioral changes has been scarcely investigated. In comparison to fucoidan from other brown seaweeds, that from exhibited a better neuroprotective effect in vivo and more potent radical scavenging activity in vitro. Fucoidan from ameliorates behavioral disorders related to acute ulcerative colitis (UC) in aged mice. It is of interest to assess the effects of fucoidan administration on intestinal and brain inflammation in the acute colitis mouse model. Fucoidan treatment ameliorated DSS-induced intestinal pathology, reduced the inflammatory mediator expression in the gut and brain, and activated intestinal macrophages and cortical microglia in the UC mice. It also protected the intestinal mucosal barrier and blood-brain barrier as well as prevented neuronal damage, while alleviating anxiety-like behavior in UC mice. These results suggest fucoidan supplementation may help prevent brain disorders, such as depression and PD, potentially involving gut-brain axis-related mechanisms, as fucoidan suppresses gut-derived neuroinflammation. |
| format | Artículo científico |
| id | pubmed_41590739 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Fucoidan Extracted from Ameliorates Colitis-Associated Neuroinflammation and Anxiety-like Behavior in Adult C57BL/6 Mice. Song, Xiaoyu Li, Na Li, Xiujie Yuan, Bo Zhang, Xuan Li, Sheng Yang, Xiaojing Qi, Bing Yin, Shixuan Li, Chunxue Huang, Yangting Zhang, Ben Guo, Yanjie Zhao, Jie Wu, Xuefei Animals Polysaccharides Mice Fucus Mice, Inbred C57BL Anxiety Male Disease Models, Animal Neuroinflammatory Diseases Neuroprotective Agents Colitis, Ulcerative Colitis Brain Anti-Inflammatory Agents Microglia Behavior, Animal Dextran Sulfate Blood-Brain Barrier Fucoidan Extracted from Ameliorates Colitis-Associated Neuroinflammation and Anxiety-like Behavior in Adult C57BL/6 Mice. Song, Xiaoyu Li, Na Li, Xiujie Yuan, Bo Zhang, Xuan Li, Sheng Yang, Xiaojing Qi, Bing Yin, Shixuan Li, Chunxue Huang, Yangting Zhang, Ben Guo, Yanjie Zhao, Jie Wu, Xuefei Animals Polysaccharides Mice Fucus Mice, Inbred C57BL Anxiety Male Disease Models, Animal Neuroinflammatory Diseases Neuroprotective Agents Colitis, Ulcerative Colitis Brain Anti-Inflammatory Agents Microglia Behavior, Animal Dextran Sulfate Blood-Brain Barrier Fucoidan, a complex sulfated polysaccharide derived from marine brown seaweeds, exhibits broad biological activities, including anticoagulant, antitumor, antiviral, anti-inflammatory and lipid-lowering effects. Fucoidan confers neuroprotection in animal models of a broad spectrum of brain disorders such as Parkinson's disease (PD) and depression. However, the effect of fucoidan on gut-derived neuroinflammation and associated behavioral changes has been scarcely investigated. In comparison to fucoidan from other brown seaweeds, that from exhibited a better neuroprotective effect in vivo and more potent radical scavenging activity in vitro. Fucoidan from ameliorates behavioral disorders related to acute ulcerative colitis (UC) in aged mice. It is of interest to assess the effects of fucoidan administration on intestinal and brain inflammation in the acute colitis mouse model. Fucoidan treatment ameliorated DSS-induced intestinal pathology, reduced the inflammatory mediator expression in the gut and brain, and activated intestinal macrophages and cortical microglia in the UC mice. It also protected the intestinal mucosal barrier and blood-brain barrier as well as prevented neuronal damage, while alleviating anxiety-like behavior in UC mice. These results suggest fucoidan supplementation may help prevent brain disorders, such as depression and PD, potentially involving gut-brain axis-related mechanisms, as fucoidan suppresses gut-derived neuroinflammation. |
| title | Fucoidan Extracted from Ameliorates Colitis-Associated Neuroinflammation and Anxiety-like Behavior in Adult C57BL/6 Mice. |
| topic | Animals Polysaccharides Mice Fucus Mice, Inbred C57BL Anxiety Male Disease Models, Animal Neuroinflammatory Diseases Neuroprotective Agents Colitis, Ulcerative Colitis Brain Anti-Inflammatory Agents Microglia Behavior, Animal Dextran Sulfate Blood-Brain Barrier |
| url | https://pubmed.ncbi.nlm.nih.gov/41590739/ |