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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
BMC biology
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41612263/ |
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| _version_ | 1868266092665765890 |
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| author | Brunner, Ramona Grinblat, Mila Moya, Aurelie Foret, Sylvain Hayward, David C Lapeyre, Bruno Ball, Eldon E Cooke, Ira Miller, David J |
| author_facet | Brunner, Ramona Grinblat, Mila Moya, Aurelie Foret, Sylvain Hayward, David C Lapeyre, Bruno Ball, Eldon E Cooke, Ira Miller, David J Brunner, Ramona Grinblat, Mila Moya, Aurelie Foret, Sylvain Hayward, David C Lapeyre, Bruno Ball, Eldon E Cooke, Ira Miller, David J |
| collection | PubMed - marine biology |
| contents | Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora. Brunner, Ramona Grinblat, Mila Moya, Aurelie Foret, Sylvain Hayward, David C Lapeyre, Bruno Ball, Eldon E Cooke, Ira Miller, David J Animals Anthozoa Transcriptome Gene Expression Regulation, Developmental Gene Expression Profiling Given the ecological importance of reef-building corals (Scleractinia), it is perhaps surprising that the molecular mechanisms underlying many of the morphological and metabolic changes during their development remain unclear. In part, this is due to the lack of a comprehensive transcriptomic dataset for any coral. A second challenge in the analysis of such non-model developmental datasets is that the volume of data often complicates its interpretation. To overcome these limitations, we profiled gene expression in Acropora millepora across 26 life stages from unfertilised eggs to juvenile polyps and developed an interactive online tool based on the R-application Shiny to simultaneously visualise changes in the expression of large numbers of genes. As expected, major transcriptomic changes (transitions) occurred during gastrulation and the acquisition of competence. Surprisingly, however, settlement triggered by using an extract of the natural inducing crustose coralline alga did not immediately lead to major changes in gene expression, but a major transition involving many genes was observed 3-6 h after settlement induction. We hope that providing access to this extensive developmental transcriptome dataset and software to facilitate its analysis will expedite a better understanding of the changes that occur during coral development. The online tool is available at https://amil-deview.mmb.group . |
| format | Artículo científico |
| id | pubmed_41612263 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | BMC biology |
| record_format | pubmed |
| spellingShingle | Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora. Brunner, Ramona Grinblat, Mila Moya, Aurelie Foret, Sylvain Hayward, David C Lapeyre, Bruno Ball, Eldon E Cooke, Ira Miller, David J Animals Anthozoa Transcriptome Gene Expression Regulation, Developmental Gene Expression Profiling Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora. Brunner, Ramona Grinblat, Mila Moya, Aurelie Foret, Sylvain Hayward, David C Lapeyre, Bruno Ball, Eldon E Cooke, Ira Miller, David J Animals Anthozoa Transcriptome Gene Expression Regulation, Developmental Gene Expression Profiling Given the ecological importance of reef-building corals (Scleractinia), it is perhaps surprising that the molecular mechanisms underlying many of the morphological and metabolic changes during their development remain unclear. In part, this is due to the lack of a comprehensive transcriptomic dataset for any coral. A second challenge in the analysis of such non-model developmental datasets is that the volume of data often complicates its interpretation. To overcome these limitations, we profiled gene expression in Acropora millepora across 26 life stages from unfertilised eggs to juvenile polyps and developed an interactive online tool based on the R-application Shiny to simultaneously visualise changes in the expression of large numbers of genes. As expected, major transcriptomic changes (transitions) occurred during gastrulation and the acquisition of competence. Surprisingly, however, settlement triggered by using an extract of the natural inducing crustose coralline alga did not immediately lead to major changes in gene expression, but a major transition involving many genes was observed 3-6 h after settlement induction. We hope that providing access to this extensive developmental transcriptome dataset and software to facilitate its analysis will expedite a better understanding of the changes that occur during coral development. The online tool is available at https://amil-deview.mmb.group . |
| title | Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora. |
| topic | Animals Anthozoa Transcriptome Gene Expression Regulation, Developmental Gene Expression Profiling |
| url | https://pubmed.ncbi.nlm.nih.gov/41612263/ |