Buchumschlag

Exploring natural products as Bcl-2 inhibitors for acute myeloid leukemia therapy using In vitro, STD-NMR spectroscopy, and In silico approaches.

Fuente: PubMed

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Rahman, Noor, Zafar, Humaira, Rajendran, Thirugnanasambandam, Sharif, Ruby, Almehdi, Ahmed, Tul-Wahab, Atia, Sheikh, Sumbla, Choudhary, M Iqbal
Format:	Artículo científico
Sprache:	en
Veröffentlicht:	Computers in biology and medicine 2026
Schlagworte:	Humans Leukemia, Myeloid, Acute Proto-Oncogene Proteins c-bcl-2 HL-60 Cells Molecular Docking Simulation Biological Products Apoptosis Magnetic Resonance Spectroscopy Antineoplastic Agents Molecular Dynamics Simulation Cell Proliferation Gossypol
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Molecular docking and in vitro anticancer evaluation of potential compounds derived from Indonesian sponge Agelas nakamurai.
von: Budiyanto, Fitri, et al.
Veröffentlicht: (2025)

Computational Analysis of Azole Derivatives Targeting the PI3K/AKT/mTOR Pathway With In Vitro Cytotoxicity and Autophagy Evaluation.
von: Regurajan, Rathika, et al.
Veröffentlicht: (2026)

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways.
von: Khine, Hnin Ei Ei, et al.
Veröffentlicht: (2025)

Molecular docking and antitumor evaluation of liposomal nanoformulations containing citrinin.
von: de Menezes, Ag-Anne Pereira Melo, et al.
Veröffentlicht: (2025)

In vitro cytotoxic and pro-apoptotic effects of Chaetoceros socialis ethanolic extract on prostate (LNCap) and glioblastoma (U-87 MG) cells via modulation of AKT/PTEN, mTOR, BAX/BCL2, and Caspase pathways.
von: Asoudeh-Fard, Abbas, et al.
Veröffentlicht: (2025)

The Synergistic Effects of rhArg with Bcl-2 Inhibitors or Metformin Co-Treatment in Multiple Cancer Cell Models.
von: Sze, Lai-Pan, et al.
Veröffentlicht: (2026)

Ultrasonication-assisted green synthesis, in silico EGFR-binding analysis, and cytotoxic evaluation of nitro-perimidines for non-small cell lung cancer.
von: Gopinadh, Meera, et al.
Veröffentlicht: (2026)

The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML.
von: Xu, Song'en, et al.
Veröffentlicht: (2025)

Cytotoxicity, apoptosis, molecular docking, and molecular dynamics study of novel compounds of Sulfamide derivatives coupled with DHP scaffolds as potent inhibitors of the MCF-7, A549, SKOV-3, and EA. yh926 carcinoma cells.
von: Abdulrasool, Amjed, et al.
Veröffentlicht: (2026)

Capsular polysaccharide from the marine bacterium Cobetia marina induces apoptosis via both caspase-dependent and mitochondria-mediated pathways in HL-60 cells.
von: Kokoulin, Maxim S, et al.
Veröffentlicht: (2025)

Decoding the multifunctional potential of ursolic acid: antioxidant, antiproliferative, molecular dynamics, and biodegradability evaluations of a mangrove-derived terpenoid.
von: Parthiban, Anaikutti, et al.
Veröffentlicht: (2025)

Novel Sulfated Oligosaccharide DP9 from Marine Algae, : A Potent Galectin-3 Inhibitor for Pancreatic Cancer Therapy.
von: Liu, Pingting, et al.
Veröffentlicht: (2025)

Anticancer, antimicrobial, insecticidal and molecular docking of sarcotrocheliol and cholesterol from the marine soft coral Sarcophyton Trocheliophorum.
von: Bashar, Mansour A E, et al.
Veröffentlicht: (2024)

Marine-Inspired Ovothiol Analogs Inhibit Membrane-Bound Gamma-Glutamyl-Transpeptidase and Modulate Reactive Oxygen Species and Glutathione Levels in Human Leukemic Cells.
von: Zuccarotto, Annalisa, et al.
Veröffentlicht: (2025)

Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches.
von: Saif, Ahmed, et al.
Veröffentlicht: (2025)

3-Bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia by a pro-oxidant mechanism.
von: Pereira-Vieira, Joana, et al.
Veröffentlicht: (2025)

Unlocking the potential of marine natural product fragments for rational anticancer drug design: a computational approach.
von: Gomez, Marineil C, et al.
Veröffentlicht: (2026)

Target Screening and Validation of the Antitumor Effect of Saponin Extract From Holothuria leucospilota.
von: Xu, Fuju, et al.
Veröffentlicht: (2025)

Exploring the Protective Effects of Two Alkaloids and from C23-3 on Neuronal Cells by Combining Bioinformatics Prediction and Experimental Verification.
von: Chen, Minqi, et al.
Veröffentlicht: (2025)

Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation.
von: Deng, Guangli, et al.
Veröffentlicht: (2026)

Chrysogenones A-E: Malonyl-Modified Ergosterone Derivatives from Deep-Sea-Derived sp. MCCC 3A00121 as Inhibitors of Renal Fibroblast Activation.
von: Li, Zeqing, et al.
Veröffentlicht: (2026)

An extremely rare case of concurrent BRAF V600E mutation driven hairy cell leukemia and melanoma: case report and review of literature
von: Amir Ghorbani-Aghbolaghi
Veröffentlicht: (2017)

Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
von: Chen, Xiaohui, et al.
Veröffentlicht: (2025)

Evaluating the estrogen degradation potential of laccase and peroxidase from Bacillus ligniniphilus L1 through integrated computational and experimental approaches.
von: Nawaz, Muhammad Zohaib, et al.
Veröffentlicht: (2024)

The novel marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol exhibits anticancer activity by regulating multiple signaling pathways in human glioblastoma cells: Blocking EGF signaling.
von: Yamaguchi, Masayoshi, et al.
Veröffentlicht: (2025)

Phytochemicals From Hansenia weberbaueriana for Psoriasis and Inflammatory Bowel Disease Comorbidity: Based on Network Pharmacology and In Vitro Analysis.
von: Tian, Yuhong, et al.
Veröffentlicht: (2025)

Structural and functional insights into glycosyltransferase from Nocardia asteroides NCTC11293 and structure-guided discovery of marine and phytochemical leads through pharmacokinetic screening and molecular dynamics studies.
von: Muthuvairam Subbulakshmi, Maharaja, et al.
Veröffentlicht: (2026)

Demethylmycemycin A, a dibenzoxazepinone from the marine-derived Dactylosporangium sp. OK1079, with prostate cancer suppressive effects via targeting BRK-FAK-STAT3 axis.
von: Elsbaey, Marwa, et al.
Veröffentlicht: (2026)

Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
von: Wicaksono, Danar, et al.
Veröffentlicht: (2024)

Distal enhancer RNAs regulate alternative promoter usage of MYB and drug resistance in human leukemia cells.
von: Wang, Yucheng, et al.
Veröffentlicht: (2026)

Hybrid Computational Framework Integrating Ensemble Learning, Molecular Docking, and Dynamics for Predicting Antimalarial Efficacy of Malaria Box Compounds.
von: Moreno, Martín, et al.
Veröffentlicht: (2026)

JAK2-mutated acute myeloid leukemia: comparison of next-generation sequencing (NGS) and single nucleotide polymorphism array (SNPa) findings between two cases
von: Thiago Rodrigo de Noronha
Veröffentlicht: (2019)

Computational Analysis of Excavatolide B-Human STING Interactions Implicates a Cys148-Adjacent Corridor with Within-Cavity Sub-Pose Diversity.
von: Chang, Tien-Lin, et al.
Veröffentlicht: (2026)

Exploring marine-derived bacterial compounds targeting the μ-opioid receptor agonists through metabolic profiling to molecular modeling.
von: Boudrahem, Daouia, et al.
Veröffentlicht: (2025)

Exploring Marine natural products as potential Quorum sensing inhibitors by targeting the PqsR in Pseudomonas aeruginosa: Virtual screening assisted structural dynamics study.
von: Jayaraman, Manikandan, et al.
Veröffentlicht: (2025)

Exploring phytochemicals and marine natural products as alternative therapeutic agents targeting phosphotransacetylase (PTA) in Mycobacterium tuberculosis: An underexplored drug target.
von: Subramaniyan, Sneha, et al.
Veröffentlicht: (2025)

Identification and anticoagulant mechanisms of novel factor XIa inhibitory peptides by virtual screening of a in silico generated deep-sea peptide database.
von: Ouyang, Yuhong, et al.
Veröffentlicht: (2024)

Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1.
von: Tao, Xiaoyu, et al.
Veröffentlicht: (2025)

In silico evaluation of bioactive compounds from the sea urchin Temnopleurus toreumaticus: Potential multifunctional agents against mosquito vectors and tropical pathogens.
von: Ramachandran, Karnan, et al.
Veröffentlicht: (2026)

New Asperterol from the coral associated fungus Aspergillus terreus, which protects against UVB induced damage through antioxidant, anti-inflammatory, and barrier repair mechanisms.
von: Tang, Guangming, et al.
Veröffentlicht: (2025)