Evolution and diversity of oxidoreductases involved in redox balance and energy conservation.
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Nature ecology & evolution
2026
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| _version_ | 1868266090053763072 |
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| author | Garcia, Pierre Simon De Anda, Valerie Baker, Brett J Gribaldo, Simonetta Borrel, Guillaume |
| author_facet | Garcia, Pierre Simon De Anda, Valerie Baker, Brett J Gribaldo, Simonetta Borrel, Guillaume Garcia, Pierre Simon De Anda, Valerie Baker, Brett J Gribaldo, Simonetta Borrel, Guillaume |
| collection | PubMed - marine biology |
| contents | Evolution and diversity of oxidoreductases involved in redox balance and energy conservation. Garcia, Pierre Simon De Anda, Valerie Baker, Brett J Gribaldo, Simonetta Borrel, Guillaume Oxidation-Reduction Oxidoreductases Archaea Evolution, Molecular Energy Metabolism Bacteria Archaeal Proteins Bacterial Proteins The regulation of redox balance and energy conservation is fundamental to life and relies on a large evolutionary network of oxidoreductases forming homologous protein complexes, collectively termed HORBEC (homologous oxidoreductase complexes involved in redox balance and energy conservation). These include hydrogenases, respiratory complex I and electron-bifurcating complexes, central to respiration, fermentation and methanogenesis. Despite their crucial role, a comprehensive investigation of the diversity and evolutionary history of HORBEC has been lacking. Here we exhaustively identified and analysed over 50 protein families representing all HORBEC components across thousands of bacterial and archaeal genomes. We propose a unified nomenclature and classification encompassing 31 complexes and provide an annotation tool. We highlight the extensive diversity of HORBEC, especially in Archaea. We provide information on overlooked systems and identify a new one probably acting as a cation transport platform. We show that HORBEC originated via extensive tinkering of ancestral modules, driven by strong evolutionary constraints. Finally, we infer the presence of respiratory complex I in the last universal common ancestor, opening questions on its potential role in early energy metabolisms. This work provides an evolutionary framework for HORBEC, representing a fundamental resource to predict and study redox metabolisms of ecological and biotechnological significance. |
| format | Artículo científico |
| id | pubmed_41634230 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nature ecology & evolution |
| record_format | pubmed |
| spellingShingle | Evolution and diversity of oxidoreductases involved in redox balance and energy conservation. Garcia, Pierre Simon De Anda, Valerie Baker, Brett J Gribaldo, Simonetta Borrel, Guillaume Oxidation-Reduction Oxidoreductases Archaea Evolution, Molecular Energy Metabolism Bacteria Archaeal Proteins Bacterial Proteins Evolution and diversity of oxidoreductases involved in redox balance and energy conservation. Garcia, Pierre Simon De Anda, Valerie Baker, Brett J Gribaldo, Simonetta Borrel, Guillaume Oxidation-Reduction Oxidoreductases Archaea Evolution, Molecular Energy Metabolism Bacteria Archaeal Proteins Bacterial Proteins The regulation of redox balance and energy conservation is fundamental to life and relies on a large evolutionary network of oxidoreductases forming homologous protein complexes, collectively termed HORBEC (homologous oxidoreductase complexes involved in redox balance and energy conservation). These include hydrogenases, respiratory complex I and electron-bifurcating complexes, central to respiration, fermentation and methanogenesis. Despite their crucial role, a comprehensive investigation of the diversity and evolutionary history of HORBEC has been lacking. Here we exhaustively identified and analysed over 50 protein families representing all HORBEC components across thousands of bacterial and archaeal genomes. We propose a unified nomenclature and classification encompassing 31 complexes and provide an annotation tool. We highlight the extensive diversity of HORBEC, especially in Archaea. We provide information on overlooked systems and identify a new one probably acting as a cation transport platform. We show that HORBEC originated via extensive tinkering of ancestral modules, driven by strong evolutionary constraints. Finally, we infer the presence of respiratory complex I in the last universal common ancestor, opening questions on its potential role in early energy metabolisms. This work provides an evolutionary framework for HORBEC, representing a fundamental resource to predict and study redox metabolisms of ecological and biotechnological significance. |
| title | Evolution and diversity of oxidoreductases involved in redox balance and energy conservation. |
| topic | Oxidation-Reduction Oxidoreductases Archaea Evolution, Molecular Energy Metabolism Bacteria Archaeal Proteins Bacterial Proteins |
| url | https://pubmed.ncbi.nlm.nih.gov/41634230/ |