transplantation and multiple omics reveal holobiont adaptation in deep-sea mussel .
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PubMed
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| Autori principali: | , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
iScience
2026
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| Accesso online: | |
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| _version_ | 1868266087582269441 |
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| author | Wei, Tong Yan, Guoyong Perez, Maeva He, Xing Wong, Wai Chuen Xu, Ting Lan, Yi Sun, Jin Qian, Pei-Yuan |
| author_facet | Wei, Tong Yan, Guoyong Perez, Maeva He, Xing Wong, Wai Chuen Xu, Ting Lan, Yi Sun, Jin Qian, Pei-Yuan Wei, Tong Yan, Guoyong Perez, Maeva He, Xing Wong, Wai Chuen Xu, Ting Lan, Yi Sun, Jin Qian, Pei-Yuan |
| collection | PubMed - marine biology |
| contents | transplantation and multiple omics reveal holobiont adaptation in deep-sea mussel . Wei, Tong Yan, Guoyong Perez, Maeva He, Xing Wong, Wai Chuen Xu, Ting Lan, Yi Sun, Jin Qian, Pei-Yuan Deep-sea mussels rely on methane-oxidizing bacteria (MOB) endosymbionts for nutrition in methane seeps, yet the molecular mechanisms enabling holobiont resilience to environmental fluctuations remain unclear. Here, we integrate a chromosome-scale genome of . with an transplantation experiment and multi-omics analyses to investigate adaptive responses to methane limitation. Transplanting mussels to a low-methane environment for 6 days reduced MOB abundance by 30.6%. -transcriptomics showed that MOB prioritized methane oxidation via upregulated / genes but downregulated amino acid biosynthesis and non-essential pathways, indicating metabolic resource reallocation. Concurrently, host transcriptomics revealed a shift from symbiont-dependent strategies ("farming" and "milking") to filter-feeding and extracellular matrix remodeling, indicating changes in trophic level. This dynamic interplay demonstrates how the holobiont balances symbiont maintenance with alternative energy acquisition under stress and highlights the vulnerability of chemosynthetic symbioses to methane fluctuations induced by environmental changes. |
| format | Artículo científico |
| id | pubmed_41660251 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | iScience |
| record_format | pubmed |
| spellingShingle | transplantation and multiple omics reveal holobiont adaptation in deep-sea mussel . Wei, Tong Yan, Guoyong Perez, Maeva He, Xing Wong, Wai Chuen Xu, Ting Lan, Yi Sun, Jin Qian, Pei-Yuan transplantation and multiple omics reveal holobiont adaptation in deep-sea mussel . Wei, Tong Yan, Guoyong Perez, Maeva He, Xing Wong, Wai Chuen Xu, Ting Lan, Yi Sun, Jin Qian, Pei-Yuan Deep-sea mussels rely on methane-oxidizing bacteria (MOB) endosymbionts for nutrition in methane seeps, yet the molecular mechanisms enabling holobiont resilience to environmental fluctuations remain unclear. Here, we integrate a chromosome-scale genome of . with an transplantation experiment and multi-omics analyses to investigate adaptive responses to methane limitation. Transplanting mussels to a low-methane environment for 6 days reduced MOB abundance by 30.6%. -transcriptomics showed that MOB prioritized methane oxidation via upregulated / genes but downregulated amino acid biosynthesis and non-essential pathways, indicating metabolic resource reallocation. Concurrently, host transcriptomics revealed a shift from symbiont-dependent strategies ("farming" and "milking") to filter-feeding and extracellular matrix remodeling, indicating changes in trophic level. This dynamic interplay demonstrates how the holobiont balances symbiont maintenance with alternative energy acquisition under stress and highlights the vulnerability of chemosynthetic symbioses to methane fluctuations induced by environmental changes. |
| title | transplantation and multiple omics reveal holobiont adaptation in deep-sea mussel . |
| url | https://pubmed.ncbi.nlm.nih.gov/41660251/ |