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| Format: | Artículo científico |
| Sprache: | en |
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The EMBO journal
2026
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/41663842/ |
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| author | Fu, Hui-Hui Wang, Ming-Chen Wang, Zhi-Qing Sang, Yu-Han Li, Zhen-Kun Li, Fei-Fei Liu, Jia-Rong Qin, Qi-Long Zhu, Xiao-Yu Wang, Na Wan, Jin-Jian Teng, Zhao-Jie Zhang, Wei-Peng Gates, Andrew J Li, Chun-Yang Todd, Jonathan D Zhang, Yu-Zhong |
| author_facet | Fu, Hui-Hui Wang, Ming-Chen Wang, Zhi-Qing Sang, Yu-Han Li, Zhen-Kun Li, Fei-Fei Liu, Jia-Rong Qin, Qi-Long Zhu, Xiao-Yu Wang, Na Wan, Jin-Jian Teng, Zhao-Jie Zhang, Wei-Peng Gates, Andrew J Li, Chun-Yang Todd, Jonathan D Zhang, Yu-Zhong Fu, Hui-Hui Wang, Ming-Chen Wang, Zhi-Qing Sang, Yu-Han Li, Zhen-Kun Li, Fei-Fei Liu, Jia-Rong Qin, Qi-Long Zhu, Xiao-Yu Wang, Na Wan, Jin-Jian Teng, Zhao-Jie Zhang, Wei-Peng Gates, Andrew J Li, Chun-Yang Todd, Jonathan D Zhang, Yu-Zhong |
| collection | PubMed - marine biology |
| contents | Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria. Fu, Hui-Hui Wang, Ming-Chen Wang, Zhi-Qing Sang, Yu-Han Li, Zhen-Kun Li, Fei-Fei Liu, Jia-Rong Qin, Qi-Long Zhu, Xiao-Yu Wang, Na Wan, Jin-Jian Teng, Zhao-Jie Zhang, Wei-Peng Gates, Andrew J Li, Chun-Yang Todd, Jonathan D Zhang, Yu-Zhong Sulfonium Compounds Roseobacter Gene Expression Regulation, Bacterial Bacterial Proteins Oxidative Stress Aquatic Organisms Dimethylsulfoniopropionate (DMSP) catabolism by marine Roseobacters is important for global biogeochemical cycling and the climate. Many Roseobacters contain competing DMSP demethylation and cleavage pathways, but only cleavage produces the climate-cooling gas dimethylsulfide. Here, we identify the "switch" regulator in Roseobacters, DmdR, which transcriptionally represses demethylation (dmdA, encoding DMSP demethylase), cleavage (acuI, encoding acryloyl-CoA reductase) and oxidative stress protection (dmdEF, dinB) genes under low intracellular DMSP levels. Increased DMSP levels lead to DMSP cleavage and accumulation of cytotoxic cleavage product acryloyl-CoA. Acryloyl-CoA binding to DmdR derepresses dmdA-acuI transcription to stimulate acryloyl-CoA catabolism and DMSP demethylation. Upregulation of the newly identified peroxidase DmdF, and possibly also of DmdE and DinB, counteracts oxidative stress associated with DMSP demethylation. Thus, DmdR, along with DmdR-independent regulators of DMSP cleavage, likely maintains cellular DMSP levels to allow its antistress functions, but accelerates demethylation and catabolism of toxic intermediates at higher DMSP levels. Of note, DmdR appears to control acryloyl-CoA catabolism/detoxification even in abundant marine bacteria lacking dmdA, suggesting additional mechanisms. DmdR and DmdEF are widespread in Earth's oceans and important for biogeochemical cycling and climate-active gas production. |
| format | Artículo científico |
| id | pubmed_41663842 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | The EMBO journal |
| record_format | pubmed |
| spellingShingle | Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria. Fu, Hui-Hui Wang, Ming-Chen Wang, Zhi-Qing Sang, Yu-Han Li, Zhen-Kun Li, Fei-Fei Liu, Jia-Rong Qin, Qi-Long Zhu, Xiao-Yu Wang, Na Wan, Jin-Jian Teng, Zhao-Jie Zhang, Wei-Peng Gates, Andrew J Li, Chun-Yang Todd, Jonathan D Zhang, Yu-Zhong Sulfonium Compounds Roseobacter Gene Expression Regulation, Bacterial Bacterial Proteins Oxidative Stress Aquatic Organisms Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria. Fu, Hui-Hui Wang, Ming-Chen Wang, Zhi-Qing Sang, Yu-Han Li, Zhen-Kun Li, Fei-Fei Liu, Jia-Rong Qin, Qi-Long Zhu, Xiao-Yu Wang, Na Wan, Jin-Jian Teng, Zhao-Jie Zhang, Wei-Peng Gates, Andrew J Li, Chun-Yang Todd, Jonathan D Zhang, Yu-Zhong Sulfonium Compounds Roseobacter Gene Expression Regulation, Bacterial Bacterial Proteins Oxidative Stress Aquatic Organisms Dimethylsulfoniopropionate (DMSP) catabolism by marine Roseobacters is important for global biogeochemical cycling and the climate. Many Roseobacters contain competing DMSP demethylation and cleavage pathways, but only cleavage produces the climate-cooling gas dimethylsulfide. Here, we identify the "switch" regulator in Roseobacters, DmdR, which transcriptionally represses demethylation (dmdA, encoding DMSP demethylase), cleavage (acuI, encoding acryloyl-CoA reductase) and oxidative stress protection (dmdEF, dinB) genes under low intracellular DMSP levels. Increased DMSP levels lead to DMSP cleavage and accumulation of cytotoxic cleavage product acryloyl-CoA. Acryloyl-CoA binding to DmdR derepresses dmdA-acuI transcription to stimulate acryloyl-CoA catabolism and DMSP demethylation. Upregulation of the newly identified peroxidase DmdF, and possibly also of DmdE and DinB, counteracts oxidative stress associated with DMSP demethylation. Thus, DmdR, along with DmdR-independent regulators of DMSP cleavage, likely maintains cellular DMSP levels to allow its antistress functions, but accelerates demethylation and catabolism of toxic intermediates at higher DMSP levels. Of note, DmdR appears to control acryloyl-CoA catabolism/detoxification even in abundant marine bacteria lacking dmdA, suggesting additional mechanisms. DmdR and DmdEF are widespread in Earth's oceans and important for biogeochemical cycling and climate-active gas production. |
| title | Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria. |
| topic | Sulfonium Compounds Roseobacter Gene Expression Regulation, Bacterial Bacterial Proteins Oxidative Stress Aquatic Organisms |
| url | https://pubmed.ncbi.nlm.nih.gov/41663842/ |