Absence of Toll-like Receptor 21 () Gene in the Genome of Transparent Glass Catfish ().
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PubMed
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Biology
2026
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| Acceso en línea: | |
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| _version_ | 1868266087549763585 |
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| author | Guo, Shengtao Zhang, Xinhui Zhang, Rusong Zhang, Kai Chen, Jianchao Lv, Yunyun Wen, Zhengyong Chen, Jieming Bian, Chao Shi, Qiong |
| author_facet | Guo, Shengtao Zhang, Xinhui Zhang, Rusong Zhang, Kai Chen, Jianchao Lv, Yunyun Wen, Zhengyong Chen, Jieming Bian, Chao Shi, Qiong Guo, Shengtao Zhang, Xinhui Zhang, Rusong Zhang, Kai Chen, Jianchao Lv, Yunyun Wen, Zhengyong Chen, Jieming Bian, Chao Shi, Qiong |
| collection | PubMed - marine biology |
| contents | Absence of Toll-like Receptor 21 () Gene in the Genome of Transparent Glass Catfish (). Guo, Shengtao Zhang, Xinhui Zhang, Rusong Zhang, Kai Chen, Jianchao Lv, Yunyun Wen, Zhengyong Chen, Jieming Bian, Chao Shi, Qiong This study investigates the genomic basis of immune adaptation in the transparent glass catfish (: ), focusing on the loss of the Toll-like receptor 21 () gene. Comparative genomic analysis with closely related non-transparent North African catfish (: ) revealed 11 genes in the latter, while only 8 genes (, , , , , , , and ) were retained in the glass catfish, with specifically absent. Collinearity analysis confirmed that the genomic region containing is conserved across eight siluriform species, with loss exclusively in the glass catfish, supporting its lineage-specific absence. Structural expansion was notable in , , and . Molecular docking indicated that binding stability between CpG oligonucleotides and TLR21 varies significantly, with CpG-B 1681 showing the strongest interaction, which highlights sequence-dependent ligand recognition. Interestingly, absence of the gene in another transparent teleost, the X-ray tetra (), suggests that transparent fishes may share an evolutionary trend of lineage-specific gene loss. Together, these findings reveal a distinctive evolutionary trajectory in the innate immune receptor family of transparent fishes and provide new molecular insights into their adaptive immune strategies. These insights will benefit the academic community by improving comparative frameworks for fish innate immunity, and they may inform disease prevention and health management strategies in aquaculture and the ornamental fish trade. |
| format | Artículo científico |
| id | pubmed_41677735 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Biology |
| record_format | pubmed |
| spellingShingle | Absence of Toll-like Receptor 21 () Gene in the Genome of Transparent Glass Catfish (). Guo, Shengtao Zhang, Xinhui Zhang, Rusong Zhang, Kai Chen, Jianchao Lv, Yunyun Wen, Zhengyong Chen, Jieming Bian, Chao Shi, Qiong Absence of Toll-like Receptor 21 () Gene in the Genome of Transparent Glass Catfish (). Guo, Shengtao Zhang, Xinhui Zhang, Rusong Zhang, Kai Chen, Jianchao Lv, Yunyun Wen, Zhengyong Chen, Jieming Bian, Chao Shi, Qiong This study investigates the genomic basis of immune adaptation in the transparent glass catfish (: ), focusing on the loss of the Toll-like receptor 21 () gene. Comparative genomic analysis with closely related non-transparent North African catfish (: ) revealed 11 genes in the latter, while only 8 genes (, , , , , , , and ) were retained in the glass catfish, with specifically absent. Collinearity analysis confirmed that the genomic region containing is conserved across eight siluriform species, with loss exclusively in the glass catfish, supporting its lineage-specific absence. Structural expansion was notable in , , and . Molecular docking indicated that binding stability between CpG oligonucleotides and TLR21 varies significantly, with CpG-B 1681 showing the strongest interaction, which highlights sequence-dependent ligand recognition. Interestingly, absence of the gene in another transparent teleost, the X-ray tetra (), suggests that transparent fishes may share an evolutionary trend of lineage-specific gene loss. Together, these findings reveal a distinctive evolutionary trajectory in the innate immune receptor family of transparent fishes and provide new molecular insights into their adaptive immune strategies. These insights will benefit the academic community by improving comparative frameworks for fish innate immunity, and they may inform disease prevention and health management strategies in aquaculture and the ornamental fish trade. |
| title | Absence of Toll-like Receptor 21 () Gene in the Genome of Transparent Glass Catfish (). |
| url | https://pubmed.ncbi.nlm.nih.gov/41677735/ |