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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nature communications
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41680182/ |
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| _version_ | 1868266087545569283 |
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| author | Ma, Xinyi Wang, Ergang Puviindran, Vijitha Su, Ziyuan Liu, Xiaoxi Shimada, Eijiro Yan, Chengsong Liu, Yining Li, Zhenyu Nadesan, Puvi Ishikawa, Koji Nakagawa, Makoto Huang, Zeyu Wang, Xiao-Fan Alman, Benjamin Aaron |
| author_facet | Ma, Xinyi Wang, Ergang Puviindran, Vijitha Su, Ziyuan Liu, Xiaoxi Shimada, Eijiro Yan, Chengsong Liu, Yining Li, Zhenyu Nadesan, Puvi Ishikawa, Koji Nakagawa, Makoto Huang, Zeyu Wang, Xiao-Fan Alman, Benjamin Aaron Ma, Xinyi Wang, Ergang Puviindran, Vijitha Su, Ziyuan Liu, Xiaoxi Shimada, Eijiro Yan, Chengsong Liu, Yining Li, Zhenyu Nadesan, Puvi Ishikawa, Koji Nakagawa, Makoto Huang, Zeyu Wang, Xiao-Fan Alman, Benjamin Aaron |
| collection | PubMed - marine biology |
| contents | A macrophage-induced subpopulation of mesenchymal cells expressing Fcer1g contributes to wound-induced fibrosis. Ma, Xinyi Wang, Ergang Puviindran, Vijitha Su, Ziyuan Liu, Xiaoxi Shimada, Eijiro Yan, Chengsong Liu, Yining Li, Zhenyu Nadesan, Puvi Ishikawa, Koji Nakagawa, Makoto Huang, Zeyu Wang, Xiao-Fan Alman, Benjamin Aaron Animals Wound Healing Macrophages Fibrosis Mesenchymal Stem Cells Mice Humans Skin Extracellular Matrix Cell Proliferation Male Mice, Inbred C57BL Receptor, Platelet-Derived Growth Factor alpha Female Fibrosis commonly occurs during adult skin wound healing, characterized by excessive extracellular matrix (ECM), leading to scarring. Mesenchymal cells, the primary ECM-producing population, are heterogeneous with varying fibrotic propensity during healing. While pro-fibrotic embryonically derived mesenchymal lineages have been identified, adult mesenchymal cells responsible for fibrosis are not yet fully characterized. In adult mice with conditional macrophage depletion during the early phase of wound healing, wounds exhibit attenuated fibrosis and a reduction in mesenchymal cell numbers. Here we show that early phase macrophage induces a distinct PDGFRα⁺ mesenchymal population expressing Fcer1g. This cell population expands rapidly after injury, shows high proliferative activity, and is largely absent when macrophages are depleted. Targeted ablation of this cell population does not delay wound closure but results in diminished scarring. Human wound datasets identified a transcriptionally conserved FCER1G-expressing mesenchymal subset, suggesting that this pro-fibrotic mesenchymal state is preserved in human wound healing. |
| format | Artículo científico |
| id | pubmed_41680182 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | A macrophage-induced subpopulation of mesenchymal cells expressing Fcer1g contributes to wound-induced fibrosis. Ma, Xinyi Wang, Ergang Puviindran, Vijitha Su, Ziyuan Liu, Xiaoxi Shimada, Eijiro Yan, Chengsong Liu, Yining Li, Zhenyu Nadesan, Puvi Ishikawa, Koji Nakagawa, Makoto Huang, Zeyu Wang, Xiao-Fan Alman, Benjamin Aaron Animals Wound Healing Macrophages Fibrosis Mesenchymal Stem Cells Mice Humans Skin Extracellular Matrix Cell Proliferation Male Mice, Inbred C57BL Receptor, Platelet-Derived Growth Factor alpha Female A macrophage-induced subpopulation of mesenchymal cells expressing Fcer1g contributes to wound-induced fibrosis. Ma, Xinyi Wang, Ergang Puviindran, Vijitha Su, Ziyuan Liu, Xiaoxi Shimada, Eijiro Yan, Chengsong Liu, Yining Li, Zhenyu Nadesan, Puvi Ishikawa, Koji Nakagawa, Makoto Huang, Zeyu Wang, Xiao-Fan Alman, Benjamin Aaron Animals Wound Healing Macrophages Fibrosis Mesenchymal Stem Cells Mice Humans Skin Extracellular Matrix Cell Proliferation Male Mice, Inbred C57BL Receptor, Platelet-Derived Growth Factor alpha Female Fibrosis commonly occurs during adult skin wound healing, characterized by excessive extracellular matrix (ECM), leading to scarring. Mesenchymal cells, the primary ECM-producing population, are heterogeneous with varying fibrotic propensity during healing. While pro-fibrotic embryonically derived mesenchymal lineages have been identified, adult mesenchymal cells responsible for fibrosis are not yet fully characterized. In adult mice with conditional macrophage depletion during the early phase of wound healing, wounds exhibit attenuated fibrosis and a reduction in mesenchymal cell numbers. Here we show that early phase macrophage induces a distinct PDGFRα⁺ mesenchymal population expressing Fcer1g. This cell population expands rapidly after injury, shows high proliferative activity, and is largely absent when macrophages are depleted. Targeted ablation of this cell population does not delay wound closure but results in diminished scarring. Human wound datasets identified a transcriptionally conserved FCER1G-expressing mesenchymal subset, suggesting that this pro-fibrotic mesenchymal state is preserved in human wound healing. |
| title | A macrophage-induced subpopulation of mesenchymal cells expressing Fcer1g contributes to wound-induced fibrosis. |
| topic | Animals Wound Healing Macrophages Fibrosis Mesenchymal Stem Cells Mice Humans Skin Extracellular Matrix Cell Proliferation Male Mice, Inbred C57BL Receptor, Platelet-Derived Growth Factor alpha Female |
| url | https://pubmed.ncbi.nlm.nih.gov/41680182/ |