Differential Effects of and var. Extracts on Liver Steatosis in a Murine Dietary Model.
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Nutrients
2026
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| _version_ | 1868266084897914882 |
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| author | Besné-Eseverri, Irene Benito, Denis Fisico-Echezarraga, Miren Arán-González, Miguel Cano, M Pilar Portillo, María P Trepiana, Jenifer |
| author_facet | Besné-Eseverri, Irene Benito, Denis Fisico-Echezarraga, Miren Arán-González, Miguel Cano, M Pilar Portillo, María P Trepiana, Jenifer Besné-Eseverri, Irene Benito, Denis Fisico-Echezarraga, Miren Arán-González, Miguel Cano, M Pilar Portillo, María P Trepiana, Jenifer |
| collection | PubMed - marine biology |
| contents | Differential Effects of and var. Extracts on Liver Steatosis in a Murine Dietary Model. Besné-Eseverri, Irene Benito, Denis Fisico-Echezarraga, Miren Arán-González, Miguel Cano, M Pilar Portillo, María P Trepiana, Jenifer Animals Opuntia Plant Extracts Male Rats, Wistar Diet, High-Fat Liver Triglycerides Fatty Liver Disease Models, Animal Rats Fructose Lipid Metabolism : Metabolic-dysfunction-associated fatty liver disease (MASLD) is characterised by an excessive hepatic lipid accumulation. The present research aims to study the impact of an var. peel extract and an var. pulp extract, known for their high content of betalains and phenolic compounds, on the prevention of hepatic lipid accumulation in the liver of rats with steatosis. : For this, MASLD was induced in 60 male Wistar rats by a high-fat high-fructose diet. They were supplemented with var. peel extract or var. pulp extract at 25 or 100 mg/kg body weight/d. : The high-fat high-fructose diet caused an increase in final body and liver weight, hepatic triglyceride (TG) content, and altered liver histology. The increase in hepatic TG was due to the rise in fatty acid uptake and the increased assembly of TG, although increased lipogenesis cannot be ruled out. The treatment with a low dose of var. pulp extract (L-OFI group) significantly prevented hepatic TG accumulation, and the high dose (H-OFI group) showed a tendency towards lower values compared to the rats fed the high-fat high-fructose diet. The main mechanism of action appears to be a down-regulation of fatty acid uptake. By contrast, var. peel extract did not prevent the high-fat high-fructose diet-induced steatosis. : Overall, var. pulp extract may represent a potential strategy for MASLD prevention, although its beneficial effects require confirmation in human studies. |
| format | Artículo científico |
| id | pubmed_41683242 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nutrients |
| record_format | pubmed |
| spellingShingle | Differential Effects of and var. Extracts on Liver Steatosis in a Murine Dietary Model. Besné-Eseverri, Irene Benito, Denis Fisico-Echezarraga, Miren Arán-González, Miguel Cano, M Pilar Portillo, María P Trepiana, Jenifer Animals Opuntia Plant Extracts Male Rats, Wistar Diet, High-Fat Liver Triglycerides Fatty Liver Disease Models, Animal Rats Fructose Lipid Metabolism Differential Effects of and var. Extracts on Liver Steatosis in a Murine Dietary Model. Besné-Eseverri, Irene Benito, Denis Fisico-Echezarraga, Miren Arán-González, Miguel Cano, M Pilar Portillo, María P Trepiana, Jenifer Animals Opuntia Plant Extracts Male Rats, Wistar Diet, High-Fat Liver Triglycerides Fatty Liver Disease Models, Animal Rats Fructose Lipid Metabolism : Metabolic-dysfunction-associated fatty liver disease (MASLD) is characterised by an excessive hepatic lipid accumulation. The present research aims to study the impact of an var. peel extract and an var. pulp extract, known for their high content of betalains and phenolic compounds, on the prevention of hepatic lipid accumulation in the liver of rats with steatosis. : For this, MASLD was induced in 60 male Wistar rats by a high-fat high-fructose diet. They were supplemented with var. peel extract or var. pulp extract at 25 or 100 mg/kg body weight/d. : The high-fat high-fructose diet caused an increase in final body and liver weight, hepatic triglyceride (TG) content, and altered liver histology. The increase in hepatic TG was due to the rise in fatty acid uptake and the increased assembly of TG, although increased lipogenesis cannot be ruled out. The treatment with a low dose of var. pulp extract (L-OFI group) significantly prevented hepatic TG accumulation, and the high dose (H-OFI group) showed a tendency towards lower values compared to the rats fed the high-fat high-fructose diet. The main mechanism of action appears to be a down-regulation of fatty acid uptake. By contrast, var. peel extract did not prevent the high-fat high-fructose diet-induced steatosis. : Overall, var. pulp extract may represent a potential strategy for MASLD prevention, although its beneficial effects require confirmation in human studies. |
| title | Differential Effects of and var. Extracts on Liver Steatosis in a Murine Dietary Model. |
| topic | Animals Opuntia Plant Extracts Male Rats, Wistar Diet, High-Fat Liver Triglycerides Fatty Liver Disease Models, Animal Rats Fructose Lipid Metabolism |
| url | https://pubmed.ncbi.nlm.nih.gov/41683242/ |