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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of molecular sciences
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41683643/ |
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| _version_ | 1868266084896866306 |
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| author | Bentley, Vanessa L Pérez-Moreno, Jorge L Durica, David S Mykles, Donald L |
| author_facet | Bentley, Vanessa L Pérez-Moreno, Jorge L Durica, David S Mykles, Donald L Bentley, Vanessa L Pérez-Moreno, Jorge L Durica, David S Mykles, Donald L |
| collection | PubMed - marine biology |
| contents | Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes. Bentley, Vanessa L Pérez-Moreno, Jorge L Durica, David S Mykles, Donald L Animals Phylogeny Signal Transduction Fatty Acids, Unsaturated Crustacea Transcription Factors Amino Acid Sequence Transcription, Genetic Methyl farnesoate (MF) is a sesquiterpenoid hormone that controls a variety of physiological processes in crustaceans, including morphogenesis, development, reproduction, and molting. MF action is mediated by a transcriptional signaling cascade consisting of (), (), (), and () transcription factors (TFs), and transcriptional co-regulators () and (). Phylogenetic and sequence analyses revealed that these genes were highly conserved across pancrustacean species. Met and Src were characterized as basic helix-loop-helix, Period (Per)-Aryl Hydrocarbon Nuclear Translocator (ARNT)-Single-minded (Sim) protein (bHLH-PAS) TFs; Kr-h1 was characterized as a CH zinc finger TF with seven zinc finger motifs; E93 was characterized as a helix-turn-helix, pipsqueak (HTH_Psq) TF. CBP was identified by several zinc finger-binding regions with Transcription Adaptor Zinc Finger 1 and 2, Really Interesting New Gene, Plant homeodomain, and Z-type zinc finger domains; the Kinase-inducible Domain Interacting-transcription factor docking site; the Bromodomain-acetylated lysine recognition and binding site; the histone acetyltransferase domain; and a C-terminal CREB-binding region containing a nuclear receptor co-activator-binding domain. CtBP had a dehydrogenase domain with arginine-glutamate-histidine catalytic triad. 81 contigs, 45 contigs, 136 contigs, 66 contigs, 60 contigs, and 172 contigs were identified across pancrustacean taxa, including decapod crustaceans. Bioinformatic identification and annotation of these TFs and co-regulators in brachyuran Y-organ (YO) transcriptomes suggests that MF signaling influences YO ecdysteroidogenesis; functional tests in the YO are needed to establish causality. |
| format | Artículo científico |
| id | pubmed_41683643 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of molecular sciences |
| record_format | pubmed |
| spellingShingle | Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes. Bentley, Vanessa L Pérez-Moreno, Jorge L Durica, David S Mykles, Donald L Animals Phylogeny Signal Transduction Fatty Acids, Unsaturated Crustacea Transcription Factors Amino Acid Sequence Transcription, Genetic Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes. Bentley, Vanessa L Pérez-Moreno, Jorge L Durica, David S Mykles, Donald L Animals Phylogeny Signal Transduction Fatty Acids, Unsaturated Crustacea Transcription Factors Amino Acid Sequence Transcription, Genetic Methyl farnesoate (MF) is a sesquiterpenoid hormone that controls a variety of physiological processes in crustaceans, including morphogenesis, development, reproduction, and molting. MF action is mediated by a transcriptional signaling cascade consisting of (), (), (), and () transcription factors (TFs), and transcriptional co-regulators () and (). Phylogenetic and sequence analyses revealed that these genes were highly conserved across pancrustacean species. Met and Src were characterized as basic helix-loop-helix, Period (Per)-Aryl Hydrocarbon Nuclear Translocator (ARNT)-Single-minded (Sim) protein (bHLH-PAS) TFs; Kr-h1 was characterized as a CH zinc finger TF with seven zinc finger motifs; E93 was characterized as a helix-turn-helix, pipsqueak (HTH_Psq) TF. CBP was identified by several zinc finger-binding regions with Transcription Adaptor Zinc Finger 1 and 2, Really Interesting New Gene, Plant homeodomain, and Z-type zinc finger domains; the Kinase-inducible Domain Interacting-transcription factor docking site; the Bromodomain-acetylated lysine recognition and binding site; the histone acetyltransferase domain; and a C-terminal CREB-binding region containing a nuclear receptor co-activator-binding domain. CtBP had a dehydrogenase domain with arginine-glutamate-histidine catalytic triad. 81 contigs, 45 contigs, 136 contigs, 66 contigs, 60 contigs, and 172 contigs were identified across pancrustacean taxa, including decapod crustaceans. Bioinformatic identification and annotation of these TFs and co-regulators in brachyuran Y-organ (YO) transcriptomes suggests that MF signaling influences YO ecdysteroidogenesis; functional tests in the YO are needed to establish causality. |
| title | Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes. |
| topic | Animals Phylogeny Signal Transduction Fatty Acids, Unsaturated Crustacea Transcription Factors Amino Acid Sequence Transcription, Genetic |
| url | https://pubmed.ncbi.nlm.nih.gov/41683643/ |