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| Natura: | Artículo científico |
| Lingua: | en |
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International journal of biological macromolecules
2026
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| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41690339/ |
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| _version_ | 1868266084887429120 |
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| author | Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang |
| author_facet | Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang |
| collection | PubMed - marine biology |
| contents | Hyaluronic acid electrospun nanofiber patch for accelerated chronic recurrent oral aphthous ulcers. Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang Nanofibers Hyaluronic Acid Animals Humans Rats Anti-Bacterial Agents Stomatitis, Aphthous Rats, Sprague-Dawley Wound Healing Dopamine In this study, we electrospun a bio-resorbable nanofiber patch from dopamine-crosslinked hyaluronic acid (HA) that combines mucoadhesion, antibacterial activity and pro-healing functions. Sodium periodate oxidation of HA under acidic conditions generated aldehyde-rich oxidized HA (OHA) that was subsequently conjugated with dopamine hydrochloride through dual aldehyde/carboxyl reactions, yielding dopamine-OHA (DHA) with 12.8% substitution. Optimized electrospinning (8% w/w DHA, 5:5 spinning-aid ratio, 18 kV, 1.2 mL h, 20 cm gap) produced uniform nanofibers (162 ± 3.32 nm) that were post-crosslinked with ε-poly-l-lysine (EPL) to enhance wet strength, slow dissolution and introduce rapid antibacterial action against oral pathogens. UV-vis, FT-IR and SEM confirmed covalent incorporation of catechol and EPL throughout the fibrous matrix. The resulting DHA-EPL nanofibers patch (DHA-EPLNFs) showed |
| format | Artículo científico |
| id | pubmed_41690339 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | Hyaluronic acid electrospun nanofiber patch for accelerated chronic recurrent oral aphthous ulcers. Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang Nanofibers Hyaluronic Acid Animals Humans Rats Anti-Bacterial Agents Stomatitis, Aphthous Rats, Sprague-Dawley Wound Healing Dopamine Hyaluronic acid electrospun nanofiber patch for accelerated chronic recurrent oral aphthous ulcers. Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang Nanofibers Hyaluronic Acid Animals Humans Rats Anti-Bacterial Agents Stomatitis, Aphthous Rats, Sprague-Dawley Wound Healing Dopamine In this study, we electrospun a bio-resorbable nanofiber patch from dopamine-crosslinked hyaluronic acid (HA) that combines mucoadhesion, antibacterial activity and pro-healing functions. Sodium periodate oxidation of HA under acidic conditions generated aldehyde-rich oxidized HA (OHA) that was subsequently conjugated with dopamine hydrochloride through dual aldehyde/carboxyl reactions, yielding dopamine-OHA (DHA) with 12.8% substitution. Optimized electrospinning (8% w/w DHA, 5:5 spinning-aid ratio, 18 kV, 1.2 mL h, 20 cm gap) produced uniform nanofibers (162 ± 3.32 nm) that were post-crosslinked with ε-poly-l-lysine (EPL) to enhance wet strength, slow dissolution and introduce rapid antibacterial action against oral pathogens. UV-vis, FT-IR and SEM confirmed covalent incorporation of catechol and EPL throughout the fibrous matrix. The resulting DHA-EPL nanofibers patch (DHA-EPLNFs) showed |
| title | Hyaluronic acid electrospun nanofiber patch for accelerated chronic recurrent oral aphthous ulcers. |
| topic | Nanofibers Hyaluronic Acid Animals Humans Rats Anti-Bacterial Agents Stomatitis, Aphthous Rats, Sprague-Dawley Wound Healing Dopamine |
| url | https://pubmed.ncbi.nlm.nih.gov/41690339/ |