Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of biological macromolecules
2026
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41690339/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Hyaluronic acid electrospun nanofiber patch for accelerated chronic recurrent oral aphthous ulcers. Sharaf, Mohamed Xu, Shufang Tiantian, Hu Khan, Tehsin Ullah Chi, Zhe Liu, Chen-Guang Nanofibers Hyaluronic Acid Animals Humans Rats Anti-Bacterial Agents Stomatitis, Aphthous Rats, Sprague-Dawley Wound Healing Dopamine In this study, we electrospun a bio-resorbable nanofiber patch from dopamine-crosslinked hyaluronic acid (HA) that combines mucoadhesion, antibacterial activity and pro-healing functions. Sodium periodate oxidation of HA under acidic conditions generated aldehyde-rich oxidized HA (OHA) that was subsequently conjugated with dopamine hydrochloride through dual aldehyde/carboxyl reactions, yielding dopamine-OHA (DHA) with 12.8% substitution. Optimized electrospinning (8% w/w DHA, 5:5 spinning-aid ratio, 18 kV, 1.2 mL h, 20 cm gap) produced uniform nanofibers (162 ± 3.32 nm) that were post-crosslinked with ε-poly-l-lysine (EPL) to enhance wet strength, slow dissolution and introduce rapid antibacterial action against oral pathogens. UV-vis, FT-IR and SEM confirmed covalent incorporation of catechol and EPL throughout the fibrous matrix. The resulting DHA-EPL nanofibers patch (DHA-EPLNFs) showed