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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Marine drugs
2026
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41745464/ |
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| _version_ | 1868266079701172226 |
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| author | Soares, Angélica R Nocchi, Nathalia Díaz-Marrero, Ana R Pereira, Renato C Fernández, José J |
| author_facet | Soares, Angélica R Nocchi, Nathalia Díaz-Marrero, Ana R Pereira, Renato C Fernández, José J Soares, Angélica R Nocchi, Nathalia Díaz-Marrero, Ana R Pereira, Renato C Fernández, José J |
| collection | PubMed - marine biology |
| contents | in Marine Environments: The Case of Elatol. Soares, Angélica R Nocchi, Nathalia Díaz-Marrero, Ana R Pereira, Renato C Fernández, José J Sesquiterpenes Biological Products Laurencia Animals Humans Aquatic Organisms Seaweed Secondary Metabolism Drug Discovery Spiro Compounds The concept of "" is introduced here to describe a privileged class of natural products defined by structural originality, biosynthetic adaptability, and broad interaction potential with biological systems. Elatol, a halogenated sesquiterpene chiefly produced by red seaweeds and occasionally accumulated by their consumers, exemplifies this concept with remarkable clarity. Its biosynthesis unfolds from farnesyl diphosphate via -bisabolane cations, bromochlorination, and stereoselective cyclization to chamigrene scaffolds, generating both (+)- and (-)-enantiomers, two metabolites with clearly distinct potential ecological roles and pharmacological profiles. This review synthesizes the current state of knowledge on elatol's distribution, biosynthetic origins, ecological relevance, and therapeutic potential. Elatol serves as a multifunctional chemical mediator, fulfilling defensive, communicative, and regulatory roles whose intensity shifts in response to herbivory, biofouling, temperature, and salinity. In parallel, its potent activities against infectious, metabolic, and neoplastic diseases highlight its growing value as a drug lead, reflected in a rising number of patent claims. Altogether, elatol emerges as a model whose ecological sophistication and biochemical versatility position it as a promising scaffold for marine-derived drug discovery. |
| format | Artículo científico |
| id | pubmed_41745464 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | in Marine Environments: The Case of Elatol. Soares, Angélica R Nocchi, Nathalia Díaz-Marrero, Ana R Pereira, Renato C Fernández, José J Sesquiterpenes Biological Products Laurencia Animals Humans Aquatic Organisms Seaweed Secondary Metabolism Drug Discovery Spiro Compounds in Marine Environments: The Case of Elatol. Soares, Angélica R Nocchi, Nathalia Díaz-Marrero, Ana R Pereira, Renato C Fernández, José J Sesquiterpenes Biological Products Laurencia Animals Humans Aquatic Organisms Seaweed Secondary Metabolism Drug Discovery Spiro Compounds The concept of "" is introduced here to describe a privileged class of natural products defined by structural originality, biosynthetic adaptability, and broad interaction potential with biological systems. Elatol, a halogenated sesquiterpene chiefly produced by red seaweeds and occasionally accumulated by their consumers, exemplifies this concept with remarkable clarity. Its biosynthesis unfolds from farnesyl diphosphate via -bisabolane cations, bromochlorination, and stereoselective cyclization to chamigrene scaffolds, generating both (+)- and (-)-enantiomers, two metabolites with clearly distinct potential ecological roles and pharmacological profiles. This review synthesizes the current state of knowledge on elatol's distribution, biosynthetic origins, ecological relevance, and therapeutic potential. Elatol serves as a multifunctional chemical mediator, fulfilling defensive, communicative, and regulatory roles whose intensity shifts in response to herbivory, biofouling, temperature, and salinity. In parallel, its potent activities against infectious, metabolic, and neoplastic diseases highlight its growing value as a drug lead, reflected in a rising number of patent claims. Altogether, elatol emerges as a model whose ecological sophistication and biochemical versatility position it as a promising scaffold for marine-derived drug discovery. |
| title | in Marine Environments: The Case of Elatol. |
| topic | Sesquiterpenes Biological Products Laurencia Animals Humans Aquatic Organisms Seaweed Secondary Metabolism Drug Discovery Spiro Compounds |
| url | https://pubmed.ncbi.nlm.nih.gov/41745464/ |