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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41745483/ |
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Table of Contents:
- Diverse and Bioactive Lactones from the Sri Lankan Mangrove-Derived Fungus sp. SCSIO41445. Wijerathna, Parakkrama Chen, Xinqi Chen, Yi Zhang, Yufan Cai, Jian Cong, Mengjing Liu, Ying Jayasinghe, Lalith Liu, Yonghong Ratnasekera, Disna Zhou, Xuefeng Talaromyces Sri Lanka Molecular Docking Simulation Neuraminidase Lactones Crystallography, X-Ray Magnetic Resonance Spectroscopy Molecular Structure Enzyme Inhibitors Three previously uncharacterized lactones, namely penicianstinoid L (), talaromyketide J () and peniciisocoumarin K (), along with twenty-eight known compounds (-), were yielded from the mangrove-derived fungus sp. SCSIO41445, collected from Mangrove Park (NARA), Sri Lanka. Their structures were established by HRESIMS and NMR spectroscopic analysis (including H and C NMR, HSQC, and HMBC), with the stereostructures of and being confirmed by single-crystal X-ray crystallographic analysis. Furthermore, compounds - were evaluated in terms of their neuraminidase (NA) inhibitory activities. These bioassay results revealed that three lactones (, , and ) of them exerted NA inhibitory effects, with IC values of 46.66 ± 2.31, 20.78 ± 1.89, and 34.14 ± 2.56 µM, respectively. Moreover, molecular docking analysis demonstrated the potential of these compounds to inhibit NA enzymes, revealing specific interactions between the compounds and target proteins.