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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine drugs
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41745488/ |
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| _version_ | 1868266079700123650 |
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| author | Vasarri, Marzia Degl'Innocenti, Donatella Lulli, Matteo Schiavone, Nicola Verdelli, Alice Caproni, Marzia Antiga, Emiliano Barletta, Emanuela |
| author_facet | Vasarri, Marzia Degl'Innocenti, Donatella Lulli, Matteo Schiavone, Nicola Verdelli, Alice Caproni, Marzia Antiga, Emiliano Barletta, Emanuela Vasarri, Marzia Degl'Innocenti, Donatella Lulli, Matteo Schiavone, Nicola Verdelli, Alice Caproni, Marzia Antiga, Emiliano Barletta, Emanuela |
| collection | PubMed - marine biology |
| contents | (L.) Delile as a Marine Anti-Inflammatory Modulator of Keratinocyte Inflammatory Responses Relevant to Psoriasis. Vasarri, Marzia Degl'Innocenti, Donatella Lulli, Matteo Schiavone, Nicola Verdelli, Alice Caproni, Marzia Antiga, Emiliano Barletta, Emanuela Skin inflammation is characterized by oxidative stress, excessive keratinocyte activation, and the overproduction of pro-inflammatory cytokines. In a previous study, we demonstrated that the hydroalcoholic extract from leaves (POE) mitigates psoriasis-like skin inflammation in a mouse model. In the present study, we investigated the cellular mechanisms underlying these effects in human HaCaT keratinocytes. Non-cytotoxic lipopolysaccharide (LPS) stimulation reproduced key inflammatory features, including impaired cell proliferation, increased production of ROS and NO, and the upregulation of IL-1β, IL-6, TNF-α and CXCL8/IL-8. Co-treatment with POE significantly attenuated these alterations by restoring cell proliferation, suppressing oxidative stress, particularly NOS2/NO, and normalizing both cytokine expression and release. POE alone did not affect cell viability or inflammatory markers, confirming its favorable safety profile. However, POE alone induced a mild pro-apoptotic response, which may contribute to overcoming the apoptosis resistance typically observed in psoriatic keratinocytes. Overall, these findings demonstrate that POE exerts antioxidant and anti-inflammatory effects in activated keratinocytes and support its potential as a marine-derived candidate for complementary strategies in the management of psoriasis-associated inflammatory skin disorders. |
| format | Artículo científico |
| id | pubmed_41745488 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | (L.) Delile as a Marine Anti-Inflammatory Modulator of Keratinocyte Inflammatory Responses Relevant to Psoriasis. Vasarri, Marzia Degl'Innocenti, Donatella Lulli, Matteo Schiavone, Nicola Verdelli, Alice Caproni, Marzia Antiga, Emiliano Barletta, Emanuela (L.) Delile as a Marine Anti-Inflammatory Modulator of Keratinocyte Inflammatory Responses Relevant to Psoriasis. Vasarri, Marzia Degl'Innocenti, Donatella Lulli, Matteo Schiavone, Nicola Verdelli, Alice Caproni, Marzia Antiga, Emiliano Barletta, Emanuela Skin inflammation is characterized by oxidative stress, excessive keratinocyte activation, and the overproduction of pro-inflammatory cytokines. In a previous study, we demonstrated that the hydroalcoholic extract from leaves (POE) mitigates psoriasis-like skin inflammation in a mouse model. In the present study, we investigated the cellular mechanisms underlying these effects in human HaCaT keratinocytes. Non-cytotoxic lipopolysaccharide (LPS) stimulation reproduced key inflammatory features, including impaired cell proliferation, increased production of ROS and NO, and the upregulation of IL-1β, IL-6, TNF-α and CXCL8/IL-8. Co-treatment with POE significantly attenuated these alterations by restoring cell proliferation, suppressing oxidative stress, particularly NOS2/NO, and normalizing both cytokine expression and release. POE alone did not affect cell viability or inflammatory markers, confirming its favorable safety profile. However, POE alone induced a mild pro-apoptotic response, which may contribute to overcoming the apoptosis resistance typically observed in psoriatic keratinocytes. Overall, these findings demonstrate that POE exerts antioxidant and anti-inflammatory effects in activated keratinocytes and support its potential as a marine-derived candidate for complementary strategies in the management of psoriasis-associated inflammatory skin disorders. |
| title | (L.) Delile as a Marine Anti-Inflammatory Modulator of Keratinocyte Inflammatory Responses Relevant to Psoriasis. |
| url | https://pubmed.ncbi.nlm.nih.gov/41745488/ |