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| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Veterinary sciences
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41746001/ |
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Table of Contents:
- Antiparasitic Activity of Extract-Loaded Chitosan Nanoparticles in Experimentally Induced Giardiasis. El-Wahsh, Hany M Braikan, Faten Abdullah Al Naguib, Doaa Morsy, Suzan Awad Abdel Ghany Abdelmenem, Alshaymaa M Ibrahim, Shaimaa G Atteia, Hebatallah Husseini Hussein, Hend Mohamed Alshumrani, Mohammad Mousa Ahmed, Ashraf Fawzy Mosa Loqa, Mariham George Moharam, Ahlam F Giardiasis, caused by , is a common gastrointestinal infection. This study aimed to evaluate the effects of leaf extract (HLE) and HLE-loaded chitosan nanoparticles (HLE-CsNPs) against isolates from individuals with gastrointestinal issues, using an experimental rat model. Stool samples from 147 participants were analyzed for , with positive samples further characterized by nested PCR-RFLP, revealing a 4.8% prevalence, all belonging to assemblage B. Ten groups of male albino rats were used to evaluate the antigiardial activity of various treatments. This included five non-infected groups [one untreated and four treated with HLE, HLE-CsNPs, CsNPs, and metronidazole (MTZ)] and five infected groups [one untreated and four similarly treated]. Treatment efficacy was assessed using parasite counts, intestinal histopathology, CD117 immunohistochemistry, and markers of liver and kidney function. HLE-CsNPs markedly reduced cysts by 88.8%, approaching the 99.2% reduction achieved by MTZ, while also improving intestinal architecture and reducing inflammation. Importantly, HLE and HLE-CsNPs provided superior protection for the liver and kidneys compared to MTZ. In conclusion, HLE-CsNPs exhibited significant antigiardial activity and organ protection in rats, suggesting a potential alternative treatment for isolated from individuals with gastrointestinal issues.