Multifactorial neural disruption in the brain of the Senegalese sole (Solea senegalensis) under ocean acidification.
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| Main Authors: | , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
2026
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| _version_ | 1868266076995846145 |
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| author | Costa, Rita A Olvera, Aurora Sylantyev, Sergiy Hubbard, Peter C Manchado, Manuel Power, Deborah M Velez, Zélia |
| author_facet | Costa, Rita A Olvera, Aurora Sylantyev, Sergiy Hubbard, Peter C Manchado, Manuel Power, Deborah M Velez, Zélia Costa, Rita A Olvera, Aurora Sylantyev, Sergiy Hubbard, Peter C Manchado, Manuel Power, Deborah M Velez, Zélia |
| collection | PubMed - marine biology |
| contents | Multifactorial neural disruption in the brain of the Senegalese sole (Solea senegalensis) under ocean acidification. Costa, Rita A Olvera, Aurora Sylantyev, Sergiy Hubbard, Peter C Manchado, Manuel Power, Deborah M Velez, Zélia Animals Ocean Acidification Flatfishes Brain Carbon Dioxide Seawater Chlorides Neurons Hydrogen-Ion Concentration Global ocean acidification, driven by rising atmospheric CO, threatens marine ecosystems and biodiversity, with increasing evidence of disruptive effects on fish neurobiology and behaviour. However, the precise mechanisms underlying these impacts remain largely unresolved.Here, we reveal how chronic exposure to future-predicted CO levels disrupts brain function in the marine teleost Solea senegalensis. Using an integrative approach combining electrophysiology, immunohistochemistry and transcriptomics, we demonstrate that elevated CO induce a complex multifaceted disruption in brain physiology. Contrary to the prevailing GABA receptor reversal hypothesis, which predicts Cl loss and heightened excitatory signalling under high CO, we observed increased Cl and HCO in cerebrospinal fluid and suppressed neural excitability. Immunohistochemistry revealed reduced expression of glial fibrillary acidic protein across multiple brain regions, suggesting glial impairment. Furthermore, transcriptomic profiling of the olfactory bulb uncovered immune modulation, downregulation of neural excitability genes, and upregulation of neuroplasticity, ciliary, and anti-inflammatory pathways, hallmarks of cellular stress adaptation. Notably, genes involved in circadian regulation and thyroid signalling were also dysregulated, pointing to broader neuroendocrine disruption. These findings challenge simplistic models of ocean acidification impact, unveiling a cascading interplay of enhanced GABAergic inhibition, immune shifts, glial dysfunction, and disrupted timekeeping mechanisms, likely contributing to the behavioural impairments under high CO. Unlike prior studies relying on behavioural assays or direct physiological proxies, our integrative approach, combining direct cerebrospinal fluid ionic measurements, electrophysiology, immunohistochemistry and transcriptomics, unveils a multifactorial physiological cascade. Our work advocated for integrative neurophysiological frameworks to predict marine fish resilience and vulnerability in a rapidly changing ocean. |
| format | Artículo científico |
| id | pubmed_41786112 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP |
| record_format | pubmed |
| spellingShingle | Multifactorial neural disruption in the brain of the Senegalese sole (Solea senegalensis) under ocean acidification. Costa, Rita A Olvera, Aurora Sylantyev, Sergiy Hubbard, Peter C Manchado, Manuel Power, Deborah M Velez, Zélia Animals Ocean Acidification Flatfishes Brain Carbon Dioxide Seawater Chlorides Neurons Hydrogen-Ion Concentration Multifactorial neural disruption in the brain of the Senegalese sole (Solea senegalensis) under ocean acidification. Costa, Rita A Olvera, Aurora Sylantyev, Sergiy Hubbard, Peter C Manchado, Manuel Power, Deborah M Velez, Zélia Animals Ocean Acidification Flatfishes Brain Carbon Dioxide Seawater Chlorides Neurons Hydrogen-Ion Concentration Global ocean acidification, driven by rising atmospheric CO, threatens marine ecosystems and biodiversity, with increasing evidence of disruptive effects on fish neurobiology and behaviour. However, the precise mechanisms underlying these impacts remain largely unresolved.Here, we reveal how chronic exposure to future-predicted CO levels disrupts brain function in the marine teleost Solea senegalensis. Using an integrative approach combining electrophysiology, immunohistochemistry and transcriptomics, we demonstrate that elevated CO induce a complex multifaceted disruption in brain physiology. Contrary to the prevailing GABA receptor reversal hypothesis, which predicts Cl loss and heightened excitatory signalling under high CO, we observed increased Cl and HCO in cerebrospinal fluid and suppressed neural excitability. Immunohistochemistry revealed reduced expression of glial fibrillary acidic protein across multiple brain regions, suggesting glial impairment. Furthermore, transcriptomic profiling of the olfactory bulb uncovered immune modulation, downregulation of neural excitability genes, and upregulation of neuroplasticity, ciliary, and anti-inflammatory pathways, hallmarks of cellular stress adaptation. Notably, genes involved in circadian regulation and thyroid signalling were also dysregulated, pointing to broader neuroendocrine disruption. These findings challenge simplistic models of ocean acidification impact, unveiling a cascading interplay of enhanced GABAergic inhibition, immune shifts, glial dysfunction, and disrupted timekeeping mechanisms, likely contributing to the behavioural impairments under high CO. Unlike prior studies relying on behavioural assays or direct physiological proxies, our integrative approach, combining direct cerebrospinal fluid ionic measurements, electrophysiology, immunohistochemistry and transcriptomics, unveils a multifactorial physiological cascade. Our work advocated for integrative neurophysiological frameworks to predict marine fish resilience and vulnerability in a rapidly changing ocean. |
| title | Multifactorial neural disruption in the brain of the Senegalese sole (Solea senegalensis) under ocean acidification. |
| topic | Animals Ocean Acidification Flatfishes Brain Carbon Dioxide Seawater Chlorides Neurons Hydrogen-Ion Concentration |
| url | https://pubmed.ncbi.nlm.nih.gov/41786112/ |