Quercetin-loaded nanoemulsions: A promising strategy for alleviating cerebral ischemic damage in an animal model of stroke.
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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Nanomedicine : nanotechnology, biology, and medicine
2026
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| _version_ | 1868266076995846144 |
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| author | Vahidi, Samira Parseghian, Liana Alvand, Zinab Moradi Bigdeli, Mohammadreza Khaksar, Sepideh Rafati, Hasan |
| author_facet | Vahidi, Samira Parseghian, Liana Alvand, Zinab Moradi Bigdeli, Mohammadreza Khaksar, Sepideh Rafati, Hasan Vahidi, Samira Parseghian, Liana Alvand, Zinab Moradi Bigdeli, Mohammadreza Khaksar, Sepideh Rafati, Hasan |
| collection | PubMed - marine biology |
| contents | Quercetin-loaded nanoemulsions: A promising strategy for alleviating cerebral ischemic damage in an animal model of stroke. Vahidi, Samira Parseghian, Liana Alvand, Zinab Moradi Bigdeli, Mohammadreza Khaksar, Sepideh Rafati, Hasan Animals Quercetin Emulsions Rats Stroke Disease Models, Animal Male Brain Ischemia Antioxidants Nanoparticles Blood-Brain Barrier Oxidative Stress Oils, Volatile Rats, Sprague-Dawley Flavonoids and nanoemulsions have attracted researchers' attention. In this study, a novel Satureja khuzistanica essential oil loaded with quercetin nanoemulsion (SKEO/Qu NE) was designed, and its effect was investigated in a stroke model. In an in vitro study, SKEO/Qu NE was characterized. SKEO/Qu NE effectiveness as an antioxidant (DPPH and NO radical scavenging, FRAP, and protein denaturation tests) and an anti-inflammatory compound (protein denaturation inhibition technique) was evaluated. In an in vivo study, rats underwent stroke-induced surgery. Rats' sensorimotor abilities, infarction, edema, and blood-brain barrier (BBB) integrity were assayed. SKEO/Qu NE showed stable nanoparticles with a mean particle size of 75.3 nm. In line with the FRAP test, the results of the DPPH and NO tests showed the maximum radical scavenging. The neurologic score, infarction, edema, and BBB breakdown were attenuated in the SKEO/Qu NE-treated group. It can be stated that SKEO/Qu NE alleviated ischemic injuries likely by attenuating oxidative stress and inflammation. |
| format | Artículo científico |
| id | pubmed_41786233 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nanomedicine : nanotechnology, biology, and medicine |
| record_format | pubmed |
| spellingShingle | Quercetin-loaded nanoemulsions: A promising strategy for alleviating cerebral ischemic damage in an animal model of stroke. Vahidi, Samira Parseghian, Liana Alvand, Zinab Moradi Bigdeli, Mohammadreza Khaksar, Sepideh Rafati, Hasan Animals Quercetin Emulsions Rats Stroke Disease Models, Animal Male Brain Ischemia Antioxidants Nanoparticles Blood-Brain Barrier Oxidative Stress Oils, Volatile Rats, Sprague-Dawley Quercetin-loaded nanoemulsions: A promising strategy for alleviating cerebral ischemic damage in an animal model of stroke. Vahidi, Samira Parseghian, Liana Alvand, Zinab Moradi Bigdeli, Mohammadreza Khaksar, Sepideh Rafati, Hasan Animals Quercetin Emulsions Rats Stroke Disease Models, Animal Male Brain Ischemia Antioxidants Nanoparticles Blood-Brain Barrier Oxidative Stress Oils, Volatile Rats, Sprague-Dawley Flavonoids and nanoemulsions have attracted researchers' attention. In this study, a novel Satureja khuzistanica essential oil loaded with quercetin nanoemulsion (SKEO/Qu NE) was designed, and its effect was investigated in a stroke model. In an in vitro study, SKEO/Qu NE was characterized. SKEO/Qu NE effectiveness as an antioxidant (DPPH and NO radical scavenging, FRAP, and protein denaturation tests) and an anti-inflammatory compound (protein denaturation inhibition technique) was evaluated. In an in vivo study, rats underwent stroke-induced surgery. Rats' sensorimotor abilities, infarction, edema, and blood-brain barrier (BBB) integrity were assayed. SKEO/Qu NE showed stable nanoparticles with a mean particle size of 75.3 nm. In line with the FRAP test, the results of the DPPH and NO tests showed the maximum radical scavenging. The neurologic score, infarction, edema, and BBB breakdown were attenuated in the SKEO/Qu NE-treated group. It can be stated that SKEO/Qu NE alleviated ischemic injuries likely by attenuating oxidative stress and inflammation. |
| title | Quercetin-loaded nanoemulsions: A promising strategy for alleviating cerebral ischemic damage in an animal model of stroke. |
| topic | Animals Quercetin Emulsions Rats Stroke Disease Models, Animal Male Brain Ischemia Antioxidants Nanoparticles Blood-Brain Barrier Oxidative Stress Oils, Volatile Rats, Sprague-Dawley |
| url | https://pubmed.ncbi.nlm.nih.gov/41786233/ |