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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nature microbiology
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41786989/ |
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| _version_ | 1868266076992700418 |
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| author | Köstlbacher, Stephan van Hooff, Jolien J E Panagiotou, Kassiani Tamarit, Daniel De Anda, Valerie Appler, Kathryn E Baker, Brett J Ettema, Thijs J G |
| author_facet | Köstlbacher, Stephan van Hooff, Jolien J E Panagiotou, Kassiani Tamarit, Daniel De Anda, Valerie Appler, Kathryn E Baker, Brett J Ettema, Thijs J G Köstlbacher, Stephan van Hooff, Jolien J E Panagiotou, Kassiani Tamarit, Daniel De Anda, Valerie Appler, Kathryn E Baker, Brett J Ettema, Thijs J G |
| collection | PubMed - marine biology |
| contents | Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Köstlbacher, Stephan van Hooff, Jolien J E Panagiotou, Kassiani Tamarit, Daniel De Anda, Valerie Appler, Kathryn E Baker, Brett J Ettema, Thijs J G Archaea Archaeal Proteins Eukaryotic Cells Models, Molecular Eukaryota Phylogeny Evolution, Molecular Genome, Archaeal Protein Conformation Asgard archaea played a key role in the origin of the eukaryotic cell, with extant genomes encoding relatives of diverse eukaryotic signature proteins (ESPs) involved in cellular organization. However, their often punctuated distribution and the absence of detectable homologues for many eukaryotic proteins limit our ability to reconstruct the cellular complexity of the Asgard archaeal ancestor of eukaryotes. Here we used de novo protein structure modelling and sequence similarity detection across an expanded Asgard archaeal genomic dataset to build a structural catalogue of the Asgard archaeal pangenome. We identified 908 'isomorphic' ESPs-Asgard archaeal proteins with statistically enriched structural matches to eukaryotic proteins, often bridging deep sequence divergence. These isomorphic ESPs are enriched in information storage and processing roles and contain key components of the eukaryotic Vault (MVP) and Commander (COMMD) complexes, with potential roles in cellular compartmentalization and endosomal processing. These findings expand the repertoire of eukaryotic-like proteins in Asgard archaea and suggest a higher degree of eukaryote-like cellular complexity in the archaeal ancestor of eukaryotes. |
| format | Artículo científico |
| id | pubmed_41786989 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nature microbiology |
| record_format | pubmed |
| spellingShingle | Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Köstlbacher, Stephan van Hooff, Jolien J E Panagiotou, Kassiani Tamarit, Daniel De Anda, Valerie Appler, Kathryn E Baker, Brett J Ettema, Thijs J G Archaea Archaeal Proteins Eukaryotic Cells Models, Molecular Eukaryota Phylogeny Evolution, Molecular Genome, Archaeal Protein Conformation Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Köstlbacher, Stephan van Hooff, Jolien J E Panagiotou, Kassiani Tamarit, Daniel De Anda, Valerie Appler, Kathryn E Baker, Brett J Ettema, Thijs J G Archaea Archaeal Proteins Eukaryotic Cells Models, Molecular Eukaryota Phylogeny Evolution, Molecular Genome, Archaeal Protein Conformation Asgard archaea played a key role in the origin of the eukaryotic cell, with extant genomes encoding relatives of diverse eukaryotic signature proteins (ESPs) involved in cellular organization. However, their often punctuated distribution and the absence of detectable homologues for many eukaryotic proteins limit our ability to reconstruct the cellular complexity of the Asgard archaeal ancestor of eukaryotes. Here we used de novo protein structure modelling and sequence similarity detection across an expanded Asgard archaeal genomic dataset to build a structural catalogue of the Asgard archaeal pangenome. We identified 908 'isomorphic' ESPs-Asgard archaeal proteins with statistically enriched structural matches to eukaryotic proteins, often bridging deep sequence divergence. These isomorphic ESPs are enriched in information storage and processing roles and contain key components of the eukaryotic Vault (MVP) and Commander (COMMD) complexes, with potential roles in cellular compartmentalization and endosomal processing. These findings expand the repertoire of eukaryotic-like proteins in Asgard archaea and suggest a higher degree of eukaryote-like cellular complexity in the archaeal ancestor of eukaryotes. |
| title | Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. |
| topic | Archaea Archaeal Proteins Eukaryotic Cells Models, Molecular Eukaryota Phylogeny Evolution, Molecular Genome, Archaeal Protein Conformation |
| url | https://pubmed.ncbi.nlm.nih.gov/41786989/ |