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| Autori principali: | , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Molecular omics
2026
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41792924/ |
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Sommario:
- Green synthesis of silver nanoparticles using Padina tetrastromatica against malaria and deciphering the mechanism through machine learning-driven metabolomics and network pharmacology. Yaladanda, Nikhila Budige, Yashwanth Kumar Veeragoni, Dileepkumar Josyula, Jhansi Venkata Nagamani Rodda, Ramesh Singh, Vineeta Sripadi, Prabhakar Mutheneni, Srinivasa Rao Silver Metabolomics Metal Nanoparticles Animals Antimalarials Machine Learning Network Pharmacology Molecular Docking Simulation Malaria Green Chemistry Technology Plasmodium falciparum Humans Cyclooxygenase 2 Mice Malaria remains a major public health challenge due to drug and insecticide resistance, underscoring the need for novel therapies with distinct mechanisms of action. In this study, silver nanoparticles were green-synthesized using the brown marine algae Padina tetrastromatica (Ag-PT) and evaluated through integrated in vitro, in vivo, metabolomics, network pharmacology, and in silico approaches. Ag-PT showed potent antiplasmodial activity, with significantly lower IC50 values and superior parasite suppression compared to chemically synthesized silver nanoparticles. Untargeted metabolomics revealed that Ag-PT treatment specifically restored malaria-induced disruptions in fatty acid, arginine, and arachidonic acid metabolism. This included elevating precursors of specialized pro-resolving mediators such as DHA, 14-HDHA, and 18-HEPE, and replenishing l-arginine to improve nitric oxide synthesis and vascular function. Integration with network pharmacology identified COX-2 (PTGS2) as a key hub gene. Molecular docking and dynamics confirmed strong binding of the Ag-PT phytochemical eriodictyol to COX-2, suggesting inhibition that shifts arachidonic acid metabolism toward anti-inflammatory specialized pro-resolving mediator production. Collectively, these findings reveal that Ag-PT offers a multifaceted therapeutic strategy by simultaneously targeting the parasite while modulating host inflammatory and metabolic pathways. This integrated therapeutic strategy highlights the potential of eco-friendly, plant-based nanomedicines as a next-generation intervention for malaria management.