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Main Authors:	Morris, Geoffrey P, Harder, Avril M, Healey, Adam L, McLaughlin, Chloee M, Rifkin, Joanna L, Cruet-Burgos, Clara, Jenkins, Jerry W, Shu, Shengqiang, Spiekerman, John J, VanGessel, Carl J, Agnew, Erica, Audebert, Alain, Barry, Kerrie, Baxter, Ivan, Beurier, Gregory, Boston, Lori Beth, Boyles, Richard E, Brady, Siobhan M, Bunting, Victoria, Chaparro, Jacqueline M, Courtney, Chaney, Dembele, Joseph Sékou B, Deshpande, Santosh, Diatta, Cyril, Eck, Nathaniel, Eveland, Andrea L, Faye, Jacques M, Flowers, Dave, Fonceka, Daniel, Gano, Boubacar, de Gracia Coquerel, Marie, Goodstein, David, Grimwood, Jane, Hudson, Matthew E, Kholova, Jana, Johnson, Katherine, Johnson, Kristen K, Kawa, Dorota, Kouressy, Mamoutou, Kresovich, Stephen, Lee, Scott, Lemaux, Peggy G, Lowery, Robert, Luquet, Delphine, Maina, Fanna, Mamidi, Sujan, McKay, John K, Michael, Todd P, Mindaye, Taye T, Mullet, John, Ozersky, Philip, Plott, Christopher, Prenni, Jessica E, Pressoir, Gael, Rami, Jean-François, Rife, Trevor W, Saxton, Jocelyn, Sine, Bassirou, Sreedasyam, Avinash, Talag, Jayson, Teme, Niaba, Tuinstra, Mitchell R, Vadez, Vincent, Vogel, John P, Walstead, Rachel, Wang, Jianan, Webber, Jenell, Williams, Melissa, Xu, Yuxing, Mockler, Todd C, Lasky, Jesse R, Rice, Brian R, Schmutz, Jeremy, Shakoor, Nadia, Lovell, John T
Format:	Artículo científico
Language:	en
Published:	Nature 2026
Subjects:	Crops, Agricultural Domestication Gene Flow Genetic Variation Genome, Plant Genomics Multigene Family Phenotype Plant Breeding Plant Leaves Quantitative Trait, Heritable Reference Standards Sorghum Nitriles
Online Access:	https://pubmed.ncbi.nlm.nih.gov/41813899/
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Table of Contents:

A sorghum pangenome reference improves global crop trait discovery. Morris, Geoffrey P Harder, Avril M Healey, Adam L McLaughlin, Chloee M Rifkin, Joanna L Cruet-Burgos, Clara Jenkins, Jerry W Shu, Shengqiang Spiekerman, John J VanGessel, Carl J Agnew, Erica Audebert, Alain Barry, Kerrie Baxter, Ivan Beurier, Gregory Boston, Lori Beth Boyles, Richard E Brady, Siobhan M Bunting, Victoria Chaparro, Jacqueline M Courtney, Chaney Dembele, Joseph Sékou B Deshpande, Santosh Diatta, Cyril Eck, Nathaniel Eveland, Andrea L Faye, Jacques M Flowers, Dave Fonceka, Daniel Gano, Boubacar de Gracia Coquerel, Marie Goodstein, David Grimwood, Jane Hudson, Matthew E Kholova, Jana Johnson, Katherine Johnson, Kristen K Kawa, Dorota Kouressy, Mamoutou Kresovich, Stephen Lee, Scott Lemaux, Peggy G Lowery, Robert Luquet, Delphine Maina, Fanna Mamidi, Sujan McKay, John K Michael, Todd P Mindaye, Taye T Mullet, John Ozersky, Philip Plott, Christopher Prenni, Jessica E Pressoir, Gael Rami, Jean-François Rife, Trevor W Saxton, Jocelyn Sine, Bassirou Sreedasyam, Avinash Talag, Jayson Teme, Niaba Tuinstra, Mitchell R Vadez, Vincent Vogel, John P Walstead, Rachel Wang, Jianan Webber, Jenell Williams, Melissa Xu, Yuxing Mockler, Todd C Lasky, Jesse R Rice, Brian R Schmutz, Jeremy Shakoor, Nadia Lovell, John T Crops, Agricultural Domestication Gene Flow Genetic Variation Genome, Plant Genomics Multigene Family Phenotype Plant Breeding Plant Leaves Quantitative Trait, Heritable Reference Standards Sorghum Nitriles Although the green revolution adapted a handful of crops to homogeneous and high-input industrialized agriculture, much of the global population still relies on the local production of variable crop cultivars by low-input smallholder farms. This diversity of unhomogenized crops, like that of the grain and bioenergy crop sorghum, offers raw materials for genetic gain and cultivar improvement. However, breeding efforts can be constrained by highly specialized traits and breeding targets. Here, to bridge this diversity, we constructed a 33-member pangenome reference and a diversity panel across 1,984 cultivars and landraces. We leveraged these resources to explore the complex interplay among historical contingency, ongoing adaptation and previously uncharacterized structural diversity. Specifically, our analyses conclusively demonstrated multiple nested and deeply diverged structural variants in the domestication gene SHATTERING1, which distinguish the previously established multicentric origin of sorghum. We then applied landscape genomics to reveal how gene flow and secondary contact created the complex genetic mosaic in contemporary breeding networks. As proof of concept for pangenome-accelerated trait discovery, we connected biosynthetic gene cluster structural variation to phenotypic leaf concentration of the cyanogenic glucoside dhurrin. Combined, these approaches will accelerate breeding and trait discovery and provide a framework for similar applications in other crops.

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