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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Natural product research
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41814942/ |
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| _version_ | 1868266074582024192 |
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| author | Paramita, Ni Luh Putu Vidya Sukmarini, Linda Ratnakomala, Shanti Islamiati, Eni Dwi Nurrohmah, Sinta Khafi, Muhammad Ariantari, Ni Putu Wulansari, Lely Retno Bustanussalam Fahrurrozi, Fahrurrozi Pratama, Idham Sumarto Imbert, Christine Nuryastuti, Titik Hertiani, Triana |
| author_facet | Paramita, Ni Luh Putu Vidya Sukmarini, Linda Ratnakomala, Shanti Islamiati, Eni Dwi Nurrohmah, Sinta Khafi, Muhammad Ariantari, Ni Putu Wulansari, Lely Retno Bustanussalam Fahrurrozi, Fahrurrozi Pratama, Idham Sumarto Imbert, Christine Nuryastuti, Titik Hertiani, Triana Paramita, Ni Luh Putu Vidya Sukmarini, Linda Ratnakomala, Shanti Islamiati, Eni Dwi Nurrohmah, Sinta Khafi, Muhammad Ariantari, Ni Putu Wulansari, Lely Retno Bustanussalam Fahrurrozi, Fahrurrozi Pratama, Idham Sumarto Imbert, Christine Nuryastuti, Titik Hertiani, Triana |
| collection | PubMed - marine biology |
| contents | Bioprospecting marine-derived sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity. Paramita, Ni Luh Putu Vidya Sukmarini, Linda Ratnakomala, Shanti Islamiati, Eni Dwi Nurrohmah, Sinta Khafi, Muhammad Ariantari, Ni Putu Wulansari, Lely Retno Bustanussalam Fahrurrozi, Fahrurrozi Pratama, Idham Sumarto Imbert, Christine Nuryastuti, Titik Hertiani, Triana This study investigates the bioprospecting potential of marine-derived bacteria from the Lombok Sea, Indonesia, as a source of anti-nontuberculous mycobacteria (anti-NTM) agents. A total of fifty-two isolates were fermented in two different media and extracted, yielding 104 crude extracts. The bioassay-guided screening was evaluated, and the extract derived from the strain SPL22-064 exhibited the most potent activity, with a minimum inhibitory concentration (MIC) of 31.25 µg/ml against ATCC 6841. The strain was identified as sp. Untargeted LC-HRMS-based analysis was performed to provide an overview of the chemical profile of the active extract. To our knowledge, this study represents the first report suggesting the potential of a marine-derived sp. as a source of antimycobacterial agents. |
| format | Artículo científico |
| id | pubmed_41814942 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Natural product research |
| record_format | pubmed |
| spellingShingle | Bioprospecting marine-derived sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity. Paramita, Ni Luh Putu Vidya Sukmarini, Linda Ratnakomala, Shanti Islamiati, Eni Dwi Nurrohmah, Sinta Khafi, Muhammad Ariantari, Ni Putu Wulansari, Lely Retno Bustanussalam Fahrurrozi, Fahrurrozi Pratama, Idham Sumarto Imbert, Christine Nuryastuti, Titik Hertiani, Triana Bioprospecting marine-derived sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity. Paramita, Ni Luh Putu Vidya Sukmarini, Linda Ratnakomala, Shanti Islamiati, Eni Dwi Nurrohmah, Sinta Khafi, Muhammad Ariantari, Ni Putu Wulansari, Lely Retno Bustanussalam Fahrurrozi, Fahrurrozi Pratama, Idham Sumarto Imbert, Christine Nuryastuti, Titik Hertiani, Triana This study investigates the bioprospecting potential of marine-derived bacteria from the Lombok Sea, Indonesia, as a source of anti-nontuberculous mycobacteria (anti-NTM) agents. A total of fifty-two isolates were fermented in two different media and extracted, yielding 104 crude extracts. The bioassay-guided screening was evaluated, and the extract derived from the strain SPL22-064 exhibited the most potent activity, with a minimum inhibitory concentration (MIC) of 31.25 µg/ml against ATCC 6841. The strain was identified as sp. Untargeted LC-HRMS-based analysis was performed to provide an overview of the chemical profile of the active extract. To our knowledge, this study represents the first report suggesting the potential of a marine-derived sp. as a source of antimycobacterial agents. |
| title | Bioprospecting marine-derived sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity. |
| url | https://pubmed.ncbi.nlm.nih.gov/41814942/ |