Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning.
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Nature communications
2026
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| author | Lewin, Thomas D Sakagami, Tosuke Shimizu, Keisuke Kao, Li-Jung Chiu, Yi-Ling Liao, Isabel Jiah-Yih Chen, Mu-En Hisata, Kanako Endo, Kazuyoshi Satoh, Noriyuki Holland, Peter W H Wong, Yue Him Luo, Yi-Jyun |
| author_facet | Lewin, Thomas D Sakagami, Tosuke Shimizu, Keisuke Kao, Li-Jung Chiu, Yi-Ling Liao, Isabel Jiah-Yih Chen, Mu-En Hisata, Kanako Endo, Kazuyoshi Satoh, Noriyuki Holland, Peter W H Wong, Yue Him Luo, Yi-Jyun Lewin, Thomas D Sakagami, Tosuke Shimizu, Keisuke Kao, Li-Jung Chiu, Yi-Ling Liao, Isabel Jiah-Yih Chen, Mu-En Hisata, Kanako Endo, Kazuyoshi Satoh, Noriyuki Holland, Peter W H Wong, Yue Him Luo, Yi-Jyun |
| collection | PubMed - marine biology |
| contents | Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning. Lewin, Thomas D Sakagami, Tosuke Shimizu, Keisuke Kao, Li-Jung Chiu, Yi-Ling Liao, Isabel Jiah-Yih Chen, Mu-En Hisata, Kanako Endo, Kazuyoshi Satoh, Noriyuki Holland, Peter W H Wong, Yue Him Luo, Yi-Jyun Animals Bone Morphogenetic Proteins Body Patterning Signal Transduction Invertebrates Genome Gene Expression Regulation, Developmental Gastrula Evolution, Molecular Phylogeny Intercellular Signaling Peptides and Proteins Glycoproteins Biological Evolution The molecular control and ancestral state of dorsal-ventral patterning within spiralians remain unclear due to the remarkable diversity across species. Here we present a chromosome-level genome for the brachiopod Lingula anatina and apply functional transcriptomics to study dorsal-ventral patterning under BMP signalling control. We uncover asymmetrical activation of BMP signalling at the dorsal side of the gastrula, governed by ventral chordin expression and a 'seesaw' of BMP ligands. Using small-molecule drugs and recombinant proteins, we show that high BMP activity inhibits genes typically associated with neural patterning during gastrula and larval stages, similar to deuterostomes and non-spiralian protostomes. Our findings suggest deep conservation of this mechanism across all three major bilaterian clades, supported by striking similarities in BMP-regulated gene sets between brachiopods and Xenopus. We argue that the spiralian ancestor retained the ancestral bilaterian mechanism, although downstream network components have undergone developmental system drift. |
| format | Artículo científico |
| id | pubmed_41820373 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning. Lewin, Thomas D Sakagami, Tosuke Shimizu, Keisuke Kao, Li-Jung Chiu, Yi-Ling Liao, Isabel Jiah-Yih Chen, Mu-En Hisata, Kanako Endo, Kazuyoshi Satoh, Noriyuki Holland, Peter W H Wong, Yue Him Luo, Yi-Jyun Animals Bone Morphogenetic Proteins Body Patterning Signal Transduction Invertebrates Genome Gene Expression Regulation, Developmental Gastrula Evolution, Molecular Phylogeny Intercellular Signaling Peptides and Proteins Glycoproteins Biological Evolution Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning. Lewin, Thomas D Sakagami, Tosuke Shimizu, Keisuke Kao, Li-Jung Chiu, Yi-Ling Liao, Isabel Jiah-Yih Chen, Mu-En Hisata, Kanako Endo, Kazuyoshi Satoh, Noriyuki Holland, Peter W H Wong, Yue Him Luo, Yi-Jyun Animals Bone Morphogenetic Proteins Body Patterning Signal Transduction Invertebrates Genome Gene Expression Regulation, Developmental Gastrula Evolution, Molecular Phylogeny Intercellular Signaling Peptides and Proteins Glycoproteins Biological Evolution The molecular control and ancestral state of dorsal-ventral patterning within spiralians remain unclear due to the remarkable diversity across species. Here we present a chromosome-level genome for the brachiopod Lingula anatina and apply functional transcriptomics to study dorsal-ventral patterning under BMP signalling control. We uncover asymmetrical activation of BMP signalling at the dorsal side of the gastrula, governed by ventral chordin expression and a 'seesaw' of BMP ligands. Using small-molecule drugs and recombinant proteins, we show that high BMP activity inhibits genes typically associated with neural patterning during gastrula and larval stages, similar to deuterostomes and non-spiralian protostomes. Our findings suggest deep conservation of this mechanism across all three major bilaterian clades, supported by striking similarities in BMP-regulated gene sets between brachiopods and Xenopus. We argue that the spiralian ancestor retained the ancestral bilaterian mechanism, although downstream network components have undergone developmental system drift. |
| title | Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning. |
| topic | Animals Bone Morphogenetic Proteins Body Patterning Signal Transduction Invertebrates Genome Gene Expression Regulation, Developmental Gastrula Evolution, Molecular Phylogeny Intercellular Signaling Peptides and Proteins Glycoproteins Biological Evolution |
| url | https://pubmed.ncbi.nlm.nih.gov/41820373/ |