Imagen de Portada

Computational Analysis of Excavatolide B-Human STING Interactions Implicates a Cys148-Adjacent Corridor with Within-Cavity Sub-Pose Diversity.

Fuente: PubMed

Guardado en:

Detalles Bibliográficos
Autores principales:	Chang, Tien-Lin, Sun, Hsiao-Yu, Sung, Ping-Jyun, Sun, Hsi-Wen
Formato:	Artículo científico
Lenguaje:	en
Publicado:	International journal of molecular sciences 2026
Materias:	Humans Molecular Dynamics Simulation Molecular Docking Simulation Membrane Proteins Diterpenes Binding Sites Protein Binding Cysteine STING Protein
Acceso en línea:	Acceder al recurso
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Binding Stability and Catalytic Mechanism of a Novel Chitin Deacetylase from and Preparation of Chitosan.
por: Liang, Bicheng, et al.
Publicado: (2025)

Structural insights into flexible pyruvate binding in an (S)-selective ω-transaminase.
por: Wu, Danni, et al.
Publicado: (2026)

Structural basis for no retinal binding in flotillin-associated rhodopsins.
por: Kovalev, Kirill, et al.
Publicado: (2025)

Phage lysis protein Lys acts as a wedge to block MurJ conformational changes.
por: Kohga, Hidetaka, et al.
Publicado: (2025)

Structural basis of a microbial trimethylamine transporter.
por: Gao, Chao, et al.
Publicado: (2025)

Conserved tripartite tail proteins mediate virophage-host interactions through lipopolysaccharide binding.
por: Chu, Ting, et al.
Publicado: (2025)

Crystal structure of a putative phosphate binding protein from Synechocystis sp. PCC 6803 reveals an evolutionary hotspot.
por: Wang, Chongyang, et al.
Publicado: (2025)

Establishment of an efficient structure-based protein clustering strategy to discovery the galactose 4-O-sulfotransferases with unexplored structural features.
por: Chen, Wencui, et al.
Publicado: (2025)

Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid.
por: Niu, Guang-Hao, et al.
Publicado: (2025)

Structural insights into bacterial dimethylsulfoniopropionate import by BCCT-family transporters.
por: Zhang, Yu-Zhong, et al.
Publicado: (2026)

Molecular Evolution and Adaptation Strategies in Marine Ciliates: An Inspiration for Cold-Adapted Enzyme Engineering and Drug Binding Analysis.
por: Pucciarelli, Sandra, et al.
Publicado: (2024)

Cryo-EM structure of the QseG-QseE complex reveals an accessory protein-driven two-component system activation mechanism.
por: Gong, Piqian, et al.
Publicado: (2025)

Structural analysis of the siderophore-interacting protein from Vibrio anguillarum and its implications in classification of Vibrio homologs.
por: Liu, Changshui, et al.
Publicado: (2024)

The structure of the Vibrio natriegens 70S ribosome in complex with the proline-rich antimicrobial peptide Bac5(1-17).
por: Raulf, Karoline, et al.
Publicado: (2025)

Structural and molecular basis for phosphate recognition by SAR11 bacteria.
por: Zhu, Wen-Jing, et al.
Publicado: (2025)

Structure-guided discovery of marine natural products as glucokinase activators for type 2 diabetes mellitus: A computational perspective.
por: Krishnakumar, Heyram, et al.
Publicado: (2026)

Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.
por: Chen, Sheng-Chia, et al.
Publicado: (2026)

Identification of Compounds Inhibiting Thermolabile Hemolysin from in Shrimp.
por: Bari, Sayed Mashequl, et al.
Publicado: (2025)

Rapid Detection of Spike Protein Receptor Binding Region of SARS-CoV-2 and Its Variants Using a Nanosheet Probe.
por: Yang, Jiacheng, et al.
Publicado: (2025)

Cryo-EM structures of photocomplexes from the free-living aerobic anoxygenic phototrophic bacterium Erythrobacter sanguineus.
por: Yue, Xing-Yu, et al.
Publicado: (2026)

STARD3-like protein from golden noble scallop is a carotenoid transfer protein capable of binding various xanthophylls.
por: Egorkin, Nikita A, et al.
Publicado: (2026)

Structural basis for nucleolin recognition of promoter G-quadruplex.
por: Chen, Luying, et al.
Publicado: (2025)

Identification of a recombinant GII.13[P21] norovirus strain: molecular dynamic simulations indicate that gene mutations shifted its spectrum of binding to host receptor glycans.
por: Chen, Yunfei, et al.
Publicado: (2025)

ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition.
por: He, Jianfeng, et al.
Publicado: (2025)

Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum.
por: Wei, Lin, et al.
Publicado: (2025)

Decoding the catalytic potential of a Cycloclasticus zancles ring-hydroxylating dioxygenase through computational analysis for enhanced PAH biodegradation.
por: Naveed, Muhammad, et al.
Publicado: (2026)

Rho GTPase dynamics distinguish between models of cortical excitability.
por: Chomchai, Dominic, et al.
Publicado: (2025)

Significant improvement of the thermostability and catalytic efficiency of β-glucosidase Bgl59 via cysteine engineering and rational design.
por: Li, Lanlan, et al.
Publicado: (2026)

Exploring Marine natural products as potential Quorum sensing inhibitors by targeting the PqsR in Pseudomonas aeruginosa: Virtual screening assisted structural dynamics study.
por: Jayaraman, Manikandan, et al.
Publicado: (2025)

Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
por: Yasir, Muhammad, et al.
Publicado: (2024)

Recognition Mechanism of RNA by TLR13: Structural Insights and Implications for Immune Activation.
por: Wang, Yibo, et al.
Publicado: (2025)

Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches.
por: Saif, Ahmed, et al.
Publicado: (2025)

Discovery of an evolutionarily distinct evasin with dual CC and CXC chemokine inhibitory activity.
por: Kunwar, Surendra, et al.
Publicado: (2026)

Data-Independent Acquisition-Based Quantitative Proteomics, Nontargeted Metabolomics, and Protein-Ligand Interaction Reveal the Mechanism of Baicalin Inhibiting βhemolytic/cytolytic Activities of .
por: Li, Guihua, et al.
Publicado: (2026)

An examination of the microbiome of Bacillus cereus (PS5) isolated from Puntius sarana (Olive barb) for α-amylase production, optimization, macromolecule extraction, and structural characterization with industrial and agricultural applications.
por: Dhayalan, Arul, et al.
Publicado: (2026)

Conserved nsp3 TM2–Y Region in Nidoviruses / MD results
por: Pustovalova, Yulia
Publicado: (2026)

A splice-site variant in the () gene identified in a symptomatic carrier woman.
por: Domoto, Aya, et al.
Publicado: (2026)

Deep homology of a cis-regulatory syntax and the evolutionary origin of the notochord.
por: Fan, Tzu-Pei, et al.
Publicado: (2025)

Catalytic Mechanism and Secondary-Structure-Type-Dependent Allosteric Regulation of β-Agarase Amaga.
por: Wang, Xinyi, et al.
Publicado: (2025)

Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
por: Bourg, Stéphane, et al.
Publicado: (2026)