Particle-associated exposure of microcystin-LR in Daphnia magna.
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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Environmental pollution (Barking, Essex : 1987)
2026
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| _version_ | 1868266071866212352 |
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| author | Kim, Namyeon Kim, Ki-Tae Lee, Seung-Woo Jung, Eui-Man Lee, Eun-Hee |
| author_facet | Kim, Namyeon Kim, Ki-Tae Lee, Seung-Woo Jung, Eui-Man Lee, Eun-Hee Kim, Namyeon Kim, Ki-Tae Lee, Seung-Woo Jung, Eui-Man Lee, Eun-Hee |
| collection | PubMed - marine biology |
| contents | Particle-associated exposure of microcystin-LR in Daphnia magna. Kim, Namyeon Kim, Ki-Tae Lee, Seung-Woo Jung, Eui-Man Lee, Eun-Hee Daphnia Microcystins Animals Marine Toxins Water Pollutants, Chemical Polystyrenes Daphnia magna Ecological risk assessments of microcystin-LR (MC-LR) predominantly rely on freely dissolved exposure, despite growing evidence that ingestion-based, particle-associated pathways can substantially alter toxin bioavailability and toxicity. This study investigated how the toxicity of MC-LR changes when exposure occurs via particulate carriers, using polystyrene (PS) particles as a well-defined model particulate system. Four exposure scenarios-control, PS alone, freely dissolved MC-LR, and MC-LR-adsorbed PS particles-were established to disentangle intrinsic particle effects from particle-associated toxin delivery in Daphnia magna. Freely dissolved MC-LR induced mild oxidative responses, whereas MC-LR associated with PS elicited the most pronounced and integrated biological responses, including reduced survival and fecundity, altered energy metabolism, and broad transcriptional activation of antioxidant, detoxification, transport, and oxygen-transport pathways. Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses of gut-recovered particles revealed nitrogen- and oxygen-containing functionalization, consistent with surface-associated transformations during gut passage. Multivariate analysis further demonstrated that particle-associated exposure produced a distinct biological response profile compared with freely dissolved MC-LR. These results demonstrate that MC-LR toxicity is strongly dependent on exposure form, and that particle-associated delivery-represented here by PS particles as a model carrier-can modify apparent MC-LR potency by promoting ingestion-based exposure and prolonged gut residence. These findings highlight the need to incorporate particle-associated cyanotoxin exposure into ecological risk assessment frameworks. |
| format | Artículo científico |
| id | pubmed_41846034 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Environmental pollution (Barking, Essex : 1987) |
| record_format | pubmed |
| spellingShingle | Particle-associated exposure of microcystin-LR in Daphnia magna. Kim, Namyeon Kim, Ki-Tae Lee, Seung-Woo Jung, Eui-Man Lee, Eun-Hee Daphnia Microcystins Animals Marine Toxins Water Pollutants, Chemical Polystyrenes Daphnia magna Particle-associated exposure of microcystin-LR in Daphnia magna. Kim, Namyeon Kim, Ki-Tae Lee, Seung-Woo Jung, Eui-Man Lee, Eun-Hee Daphnia Microcystins Animals Marine Toxins Water Pollutants, Chemical Polystyrenes Daphnia magna Ecological risk assessments of microcystin-LR (MC-LR) predominantly rely on freely dissolved exposure, despite growing evidence that ingestion-based, particle-associated pathways can substantially alter toxin bioavailability and toxicity. This study investigated how the toxicity of MC-LR changes when exposure occurs via particulate carriers, using polystyrene (PS) particles as a well-defined model particulate system. Four exposure scenarios-control, PS alone, freely dissolved MC-LR, and MC-LR-adsorbed PS particles-were established to disentangle intrinsic particle effects from particle-associated toxin delivery in Daphnia magna. Freely dissolved MC-LR induced mild oxidative responses, whereas MC-LR associated with PS elicited the most pronounced and integrated biological responses, including reduced survival and fecundity, altered energy metabolism, and broad transcriptional activation of antioxidant, detoxification, transport, and oxygen-transport pathways. Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses of gut-recovered particles revealed nitrogen- and oxygen-containing functionalization, consistent with surface-associated transformations during gut passage. Multivariate analysis further demonstrated that particle-associated exposure produced a distinct biological response profile compared with freely dissolved MC-LR. These results demonstrate that MC-LR toxicity is strongly dependent on exposure form, and that particle-associated delivery-represented here by PS particles as a model carrier-can modify apparent MC-LR potency by promoting ingestion-based exposure and prolonged gut residence. These findings highlight the need to incorporate particle-associated cyanotoxin exposure into ecological risk assessment frameworks. |
| title | Particle-associated exposure of microcystin-LR in Daphnia magna. |
| topic | Daphnia Microcystins Animals Marine Toxins Water Pollutants, Chemical Polystyrenes Daphnia magna |
| url | https://pubmed.ncbi.nlm.nih.gov/41846034/ |