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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Proceedings of the National Academy of Sciences of the United States of America
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41855267/ |
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| _version_ | 1868266071854678017 |
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| author | Andreatta, Gabriele Scaramuzza, Federico Ćorić, Aida Orel, Lukas Mat, Audrey M Takekata, Hiroki Poehn, Birgit Milivojev, Nadja Tessmar-Raible, Kristin |
| author_facet | Andreatta, Gabriele Scaramuzza, Federico Ćorić, Aida Orel, Lukas Mat, Audrey M Takekata, Hiroki Poehn, Birgit Milivojev, Nadja Tessmar-Raible, Kristin Andreatta, Gabriele Scaramuzza, Federico Ćorić, Aida Orel, Lukas Mat, Audrey M Takekata, Hiroki Poehn, Birgit Milivojev, Nadja Tessmar-Raible, Kristin |
| collection | PubMed - marine biology |
| contents | Photoreceptor control of growth and lifespan via evolutionarily conserved molecular pathways. Andreatta, Gabriele Scaramuzza, Federico Ćorić, Aida Orel, Lukas Mat, Audrey M Takekata, Hiroki Poehn, Birgit Milivojev, Nadja Tessmar-Raible, Kristin Animals Longevity Cryptochromes Signal Transduction Polychaeta Evolution, Molecular Photoreceptor Cells, Invertebrate Light Mutation Natural light is severely affected by human impact on Earth, yet little is known about the roles light receptors have outside vision and rhythmic processes, despite their tremendously wide abundance. Here we show that loss-of-function of the () in marine bristleworms significantly increases lifespan and adult size, similarly to wild-types reared in constant darkness. Quantitative transcriptomics revealed hormonal players crucial for invertebrate and vertebrate sexual development and reproduction affected in mutants. These include , ortholog of () and (), long considered vertebrate novelties. Depending on moon-phase, is up- or down-regulated in mutants. Matching the complex regulation, data consistent with loss of function partially recapitulate phenotypes. Molecularly, Nr0b1/2 affects steroidogenic and other endocrine pathways, nuclear receptor signaling, and transcription factor orthologs involved in sexual developmental, reproductive, and timing processes in other organisms. Thus, our study suggests profound and direct effects of light on adult animal life-time, likely at least in part via conserved endocrine pathways involved in sexual maturation and reproduction in annelids and vertebrates. |
| format | Artículo científico |
| id | pubmed_41855267 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Proceedings of the National Academy of Sciences of the United States of America |
| record_format | pubmed |
| spellingShingle | Photoreceptor control of growth and lifespan via evolutionarily conserved molecular pathways. Andreatta, Gabriele Scaramuzza, Federico Ćorić, Aida Orel, Lukas Mat, Audrey M Takekata, Hiroki Poehn, Birgit Milivojev, Nadja Tessmar-Raible, Kristin Animals Longevity Cryptochromes Signal Transduction Polychaeta Evolution, Molecular Photoreceptor Cells, Invertebrate Light Mutation Photoreceptor control of growth and lifespan via evolutionarily conserved molecular pathways. Andreatta, Gabriele Scaramuzza, Federico Ćorić, Aida Orel, Lukas Mat, Audrey M Takekata, Hiroki Poehn, Birgit Milivojev, Nadja Tessmar-Raible, Kristin Animals Longevity Cryptochromes Signal Transduction Polychaeta Evolution, Molecular Photoreceptor Cells, Invertebrate Light Mutation Natural light is severely affected by human impact on Earth, yet little is known about the roles light receptors have outside vision and rhythmic processes, despite their tremendously wide abundance. Here we show that loss-of-function of the () in marine bristleworms significantly increases lifespan and adult size, similarly to wild-types reared in constant darkness. Quantitative transcriptomics revealed hormonal players crucial for invertebrate and vertebrate sexual development and reproduction affected in mutants. These include , ortholog of () and (), long considered vertebrate novelties. Depending on moon-phase, is up- or down-regulated in mutants. Matching the complex regulation, data consistent with loss of function partially recapitulate phenotypes. Molecularly, Nr0b1/2 affects steroidogenic and other endocrine pathways, nuclear receptor signaling, and transcription factor orthologs involved in sexual developmental, reproductive, and timing processes in other organisms. Thus, our study suggests profound and direct effects of light on adult animal life-time, likely at least in part via conserved endocrine pathways involved in sexual maturation and reproduction in annelids and vertebrates. |
| title | Photoreceptor control of growth and lifespan via evolutionarily conserved molecular pathways. |
| topic | Animals Longevity Cryptochromes Signal Transduction Polychaeta Evolution, Molecular Photoreceptor Cells, Invertebrate Light Mutation |
| url | https://pubmed.ncbi.nlm.nih.gov/41855267/ |