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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Applied and environmental microbiology
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41860217/ |
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| _version_ | 1868266071848386561 |
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| author | Li, Xinyi Yuan, Meilin Sun, Chaomin Wu, Shimei |
| author_facet | Li, Xinyi Yuan, Meilin Sun, Chaomin Wu, Shimei Li, Xinyi Yuan, Meilin Sun, Chaomin Wu, Shimei |
| collection | PubMed - marine biology |
| contents | Pathogenic effects of on cyanobacteria and biocontrol potential of a deep-sea strain. Li, Xinyi Yuan, Meilin Sun, Chaomin Wu, Shimei Halomonas Bacillus Cyanobacteria Biological Control Agents Antibiosis Photosynthesis Seawater , a nutritionally valuable cyanobacterium with significant biomanufacturing potential, faces critical challenges from pathogenic invasions. This study identified 2-9 as the primary pathogen of cultivation collapse, demonstrating broad-spectrum algicidal activity against multiple cyanobacterial species. Additionally, the algicidal substance produced by 2-9 was purified and identified as toxic dibutyl phthalate. At a concentration of 3 µg/mL, the purified algicidal substance caused 90.6% reduction in Fv/Fm within 24 h and 86% degradation of chlorophyll- within 120 h. To be specific, Fv/Fm as the maximum photochemical quantum yield of photosystem II is a core indicator reflecting the photosynthetic activity and health status of spirulina. A sudden drop in Fv/Fm of spirulina indicates impaired function of Photosystem II. Therefore, the purified algicidal substance severely damaged the photosynthetic system of . To mitigate the detrimental effects of 2-9, L4 was isolated from deep-sea sediments. This strain produced an antimicrobial compound (CHO) that specifically inhibited 2-9 without damaging . In co-culture experiments, L4 reversed -induced algal decay, demonstrating its potential as a biocontrol agent. These findings provide both mechanistic insights into -mediated cyanobacterial pathogenesis and a practical solution for sustainable aquaculture management. This study identifies 2-9 as a novel cyanobacterial pathogen that produces hazardous compound dibutyl phthalate (DBP), causing severe damage to and exhibiting broad-spectrum algicidal activity against other cyanobacteria. The discovery of DBP-mediated pathogenesis provides crucial insights into microbial threats to aquaculture systems. Significantly, we demonstrate that L4, isolated from deep-sea environments, serves as an effective biocontrol agent through the production of a selective antimicrobial compound that specifically targets 2-9 without harming . These findings offer both fundamental understanding of cyanobacterial disease mechanisms and a practical, sustainable solution for algal disease management. |
| format | Artículo científico |
| id | pubmed_41860217 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Applied and environmental microbiology |
| record_format | pubmed |
| spellingShingle | Pathogenic effects of on cyanobacteria and biocontrol potential of a deep-sea strain. Li, Xinyi Yuan, Meilin Sun, Chaomin Wu, Shimei Halomonas Bacillus Cyanobacteria Biological Control Agents Antibiosis Photosynthesis Seawater Pathogenic effects of on cyanobacteria and biocontrol potential of a deep-sea strain. Li, Xinyi Yuan, Meilin Sun, Chaomin Wu, Shimei Halomonas Bacillus Cyanobacteria Biological Control Agents Antibiosis Photosynthesis Seawater , a nutritionally valuable cyanobacterium with significant biomanufacturing potential, faces critical challenges from pathogenic invasions. This study identified 2-9 as the primary pathogen of cultivation collapse, demonstrating broad-spectrum algicidal activity against multiple cyanobacterial species. Additionally, the algicidal substance produced by 2-9 was purified and identified as toxic dibutyl phthalate. At a concentration of 3 µg/mL, the purified algicidal substance caused 90.6% reduction in Fv/Fm within 24 h and 86% degradation of chlorophyll- within 120 h. To be specific, Fv/Fm as the maximum photochemical quantum yield of photosystem II is a core indicator reflecting the photosynthetic activity and health status of spirulina. A sudden drop in Fv/Fm of spirulina indicates impaired function of Photosystem II. Therefore, the purified algicidal substance severely damaged the photosynthetic system of . To mitigate the detrimental effects of 2-9, L4 was isolated from deep-sea sediments. This strain produced an antimicrobial compound (CHO) that specifically inhibited 2-9 without damaging . In co-culture experiments, L4 reversed -induced algal decay, demonstrating its potential as a biocontrol agent. These findings provide both mechanistic insights into -mediated cyanobacterial pathogenesis and a practical solution for sustainable aquaculture management. This study identifies 2-9 as a novel cyanobacterial pathogen that produces hazardous compound dibutyl phthalate (DBP), causing severe damage to and exhibiting broad-spectrum algicidal activity against other cyanobacteria. The discovery of DBP-mediated pathogenesis provides crucial insights into microbial threats to aquaculture systems. Significantly, we demonstrate that L4, isolated from deep-sea environments, serves as an effective biocontrol agent through the production of a selective antimicrobial compound that specifically targets 2-9 without harming . These findings offer both fundamental understanding of cyanobacterial disease mechanisms and a practical, sustainable solution for algal disease management. |
| title | Pathogenic effects of on cyanobacteria and biocontrol potential of a deep-sea strain. |
| topic | Halomonas Bacillus Cyanobacteria Biological Control Agents Antibiosis Photosynthesis Seawater |
| url | https://pubmed.ncbi.nlm.nih.gov/41860217/ |