Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo.
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| Format: | Artículo científico |
| Language: | en |
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Environmental toxicology and pharmacology
2026
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| _version_ | 1868266069672591361 |
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| author | Andrade, Ítalo B L de Pereira, Lílian C Quintaneiro, Carla Soares, Amadeu M V M Monteiro, Marta S |
| author_facet | Andrade, Ítalo B L de Pereira, Lílian C Quintaneiro, Carla Soares, Amadeu M V M Monteiro, Marta S Andrade, Ítalo B L de Pereira, Lílian C Quintaneiro, Carla Soares, Amadeu M V M Monteiro, Marta S |
| collection | PubMed - marine biology |
| contents | Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo. Andrade, Ítalo B L de Pereira, Lílian C Quintaneiro, Carla Soares, Amadeu M V M Monteiro, Marta S Animals Zebrafish Embryo, Nonmammalian Oxidative Stress Siloxanes Water Pollutants, Chemical Glutathione Transferase Heart Rate Energy Metabolism Metabolic Networks and Pathways Heart L-Lactate Dehydrogenase Decamethylcyclopentasiloxane (D5), a cyclic volatile methylsiloxane widely used in personal care products, is frequently detected in aquatic environments, yet its early-life sublethal toxicity remains poorly understood. This study investigated how increasing nominal concentrations of D5 (0.01-10 μM) affect cardiac physiology, oxidative biomarkers, and energy metabolism in zebrafish (Danio rerio) embryos after 120 h of exposure. D5 induced concentration-dependent metabolic adjustments rather than overt toxicity. At 0.1 μM, glutathione S-transferase activity increased, suggesting activation of detoxification pathways. At 1.0 μM, heart rate was elevated, indicating physiological stimulation. Higher concentrations enhanced electron transport system and lactate dehydrogenase activities, reflecting increased energetic demand and partial metabolic shift toward anaerobic pathways, accompanied by reduced cellular energy allocation. No acute behavioral alterations were observed. Overall, D5 exposure triggered coordinated metabolic reprogramming without evidence of structural oxidative damage, indicating that early biochemical perturbations may precede functional impairment. |
| format | Artículo científico |
| id | pubmed_41871643 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Environmental toxicology and pharmacology |
| record_format | pubmed |
| spellingShingle | Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo. Andrade, Ítalo B L de Pereira, Lílian C Quintaneiro, Carla Soares, Amadeu M V M Monteiro, Marta S Animals Zebrafish Embryo, Nonmammalian Oxidative Stress Siloxanes Water Pollutants, Chemical Glutathione Transferase Heart Rate Energy Metabolism Metabolic Networks and Pathways Heart L-Lactate Dehydrogenase Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo. Andrade, Ítalo B L de Pereira, Lílian C Quintaneiro, Carla Soares, Amadeu M V M Monteiro, Marta S Animals Zebrafish Embryo, Nonmammalian Oxidative Stress Siloxanes Water Pollutants, Chemical Glutathione Transferase Heart Rate Energy Metabolism Metabolic Networks and Pathways Heart L-Lactate Dehydrogenase Decamethylcyclopentasiloxane (D5), a cyclic volatile methylsiloxane widely used in personal care products, is frequently detected in aquatic environments, yet its early-life sublethal toxicity remains poorly understood. This study investigated how increasing nominal concentrations of D5 (0.01-10 μM) affect cardiac physiology, oxidative biomarkers, and energy metabolism in zebrafish (Danio rerio) embryos after 120 h of exposure. D5 induced concentration-dependent metabolic adjustments rather than overt toxicity. At 0.1 μM, glutathione S-transferase activity increased, suggesting activation of detoxification pathways. At 1.0 μM, heart rate was elevated, indicating physiological stimulation. Higher concentrations enhanced electron transport system and lactate dehydrogenase activities, reflecting increased energetic demand and partial metabolic shift toward anaerobic pathways, accompanied by reduced cellular energy allocation. No acute behavioral alterations were observed. Overall, D5 exposure triggered coordinated metabolic reprogramming without evidence of structural oxidative damage, indicating that early biochemical perturbations may precede functional impairment. |
| title | Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo. |
| topic | Animals Zebrafish Embryo, Nonmammalian Oxidative Stress Siloxanes Water Pollutants, Chemical Glutathione Transferase Heart Rate Energy Metabolism Metabolic Networks and Pathways Heart L-Lactate Dehydrogenase |
| url | https://pubmed.ncbi.nlm.nih.gov/41871643/ |