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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Biomedical materials (Bristol, England)
2026
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| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/41875532/ |
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| _version_ | 1868266069663154177 |
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| author | Nguyen, Thi Trang Huyen Nguyen, Hoang Minh Le, Anh Phuong Khong, Minh Ngoc Doan, Quang Khai Nguyen, Phuong Nhi Ha, Quang Thanh Pham, Bich Kieu Lam, Phuong Anh Quyen, Dong Van Jung, Won-Kyo Nguyen, Phuong Thi Mai Nguyen, Thi Hong Minh |
| author_facet | Nguyen, Thi Trang Huyen Nguyen, Hoang Minh Le, Anh Phuong Khong, Minh Ngoc Doan, Quang Khai Nguyen, Phuong Nhi Ha, Quang Thanh Pham, Bich Kieu Lam, Phuong Anh Quyen, Dong Van Jung, Won-Kyo Nguyen, Phuong Thi Mai Nguyen, Thi Hong Minh Nguyen, Thi Trang Huyen Nguyen, Hoang Minh Le, Anh Phuong Khong, Minh Ngoc Doan, Quang Khai Nguyen, Phuong Nhi Ha, Quang Thanh Pham, Bich Kieu Lam, Phuong Anh Quyen, Dong Van Jung, Won-Kyo Nguyen, Phuong Thi Mai Nguyen, Thi Hong Minh |
| collection | PubMed - marine biology |
| contents | Osteogenic potential of tamarind seed polysaccharide sulfate in tissue engineering. Nguyen, Thi Trang Huyen Nguyen, Hoang Minh Le, Anh Phuong Khong, Minh Ngoc Doan, Quang Khai Nguyen, Phuong Nhi Ha, Quang Thanh Pham, Bich Kieu Lam, Phuong Anh Quyen, Dong Van Jung, Won-Kyo Nguyen, Phuong Thi Mai Nguyen, Thi Hong Minh Animals Osteogenesis Tissue Engineering Polysaccharides Tamarindus Mice Tissue Scaffolds Seeds Cell Differentiation Osteoblasts Biocompatible Materials Bone Regeneration Alkaline Phosphatase Sulfates Osteoporosis Collagen Materials Testing Calcification, Physiologic Cell Proliferation Male Osteocytes Bone and Bones Bone related problems due to numerous reasons are global concerns and increasing recently. Although bone tissues have an ability to regenerate, they cannot completely heal without external intervention when severe defects occur. It is required to develop new biomaterials, termed scaffolds, that can support and induce bone tissue regeneration. A biomaterial scaffold for bone repair possesses the requirements of non-toxicity, biocompatibility, osteoconductivity, and non-immunogenicity. Among natural osteogenic compounds, tamarind seed polysaccharide (TSP) is a desirable agent for fabrication of scaffolds for bone tissue engineering due to its suitable bio-chemical properties. In the previous study, sulfated derivative of TSP was synthesized and characterized. It is proven that this TSP sulfate (TSPS) is an osteogenic compound by inducing osteoblastic cell differentiation and bone mineralization. In the current study, osteogenic activities of TSPS were further investigated. Our data showed that TSPS supplemented orally at a dose of 62.5 mg kgrescued bone loss in osteoporotic mice. Furthermore, histological images of the solid and spongy bone areas indicated that TSPS treated group improved the density and cell morphology of osteocytes and osteoblasts. From positive results observed, we further continued to study effects of TSPS on HA/Collagen/TSPS composite on bone formation by evaluating alkaline phosphatase (ALP) activity, and bone mineralization. It is shown that TSPS induced cell adherence and proliferation in HA/Collagen (HA/Col) composite. TSPS 100 µg mlsupplemented onto the culture medium and coated onto HA/Col composites resulted in increased of ALP activity to 258 ± 13% and 539 ± 38%, respectively; and of bone mineralization to 135 ± 28.8% and 119 ± 23.5%, respectively. Overall, TSPS proved to be a good osteogenic agent for bone formation and could be a highly potential candidate in pharmaceutical industry or biomaterial scaffold for bone tissue engineering. |
| format | Artículo científico |
| id | pubmed_41875532 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Biomedical materials (Bristol, England) |
| record_format | pubmed |
| spellingShingle | Osteogenic potential of tamarind seed polysaccharide sulfate in tissue engineering. Nguyen, Thi Trang Huyen Nguyen, Hoang Minh Le, Anh Phuong Khong, Minh Ngoc Doan, Quang Khai Nguyen, Phuong Nhi Ha, Quang Thanh Pham, Bich Kieu Lam, Phuong Anh Quyen, Dong Van Jung, Won-Kyo Nguyen, Phuong Thi Mai Nguyen, Thi Hong Minh Animals Osteogenesis Tissue Engineering Polysaccharides Tamarindus Mice Tissue Scaffolds Seeds Cell Differentiation Osteoblasts Biocompatible Materials Bone Regeneration Alkaline Phosphatase Sulfates Osteoporosis Collagen Materials Testing Calcification, Physiologic Cell Proliferation Male Osteocytes Bone and Bones Osteogenic potential of tamarind seed polysaccharide sulfate in tissue engineering. Nguyen, Thi Trang Huyen Nguyen, Hoang Minh Le, Anh Phuong Khong, Minh Ngoc Doan, Quang Khai Nguyen, Phuong Nhi Ha, Quang Thanh Pham, Bich Kieu Lam, Phuong Anh Quyen, Dong Van Jung, Won-Kyo Nguyen, Phuong Thi Mai Nguyen, Thi Hong Minh Animals Osteogenesis Tissue Engineering Polysaccharides Tamarindus Mice Tissue Scaffolds Seeds Cell Differentiation Osteoblasts Biocompatible Materials Bone Regeneration Alkaline Phosphatase Sulfates Osteoporosis Collagen Materials Testing Calcification, Physiologic Cell Proliferation Male Osteocytes Bone and Bones Bone related problems due to numerous reasons are global concerns and increasing recently. Although bone tissues have an ability to regenerate, they cannot completely heal without external intervention when severe defects occur. It is required to develop new biomaterials, termed scaffolds, that can support and induce bone tissue regeneration. A biomaterial scaffold for bone repair possesses the requirements of non-toxicity, biocompatibility, osteoconductivity, and non-immunogenicity. Among natural osteogenic compounds, tamarind seed polysaccharide (TSP) is a desirable agent for fabrication of scaffolds for bone tissue engineering due to its suitable bio-chemical properties. In the previous study, sulfated derivative of TSP was synthesized and characterized. It is proven that this TSP sulfate (TSPS) is an osteogenic compound by inducing osteoblastic cell differentiation and bone mineralization. In the current study, osteogenic activities of TSPS were further investigated. Our data showed that TSPS supplemented orally at a dose of 62.5 mg kgrescued bone loss in osteoporotic mice. Furthermore, histological images of the solid and spongy bone areas indicated that TSPS treated group improved the density and cell morphology of osteocytes and osteoblasts. From positive results observed, we further continued to study effects of TSPS on HA/Collagen/TSPS composite on bone formation by evaluating alkaline phosphatase (ALP) activity, and bone mineralization. It is shown that TSPS induced cell adherence and proliferation in HA/Collagen (HA/Col) composite. TSPS 100 µg mlsupplemented onto the culture medium and coated onto HA/Col composites resulted in increased of ALP activity to 258 ± 13% and 539 ± 38%, respectively; and of bone mineralization to 135 ± 28.8% and 119 ± 23.5%, respectively. Overall, TSPS proved to be a good osteogenic agent for bone formation and could be a highly potential candidate in pharmaceutical industry or biomaterial scaffold for bone tissue engineering. |
| title | Osteogenic potential of tamarind seed polysaccharide sulfate in tissue engineering. |
| topic | Animals Osteogenesis Tissue Engineering Polysaccharides Tamarindus Mice Tissue Scaffolds Seeds Cell Differentiation Osteoblasts Biocompatible Materials Bone Regeneration Alkaline Phosphatase Sulfates Osteoporosis Collagen Materials Testing Calcification, Physiologic Cell Proliferation Male Osteocytes Bone and Bones |
| url | https://pubmed.ncbi.nlm.nih.gov/41875532/ |