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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Proceedings of the National Academy of Sciences of the United States of America
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41880574/ |
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Table of Contents:
- DNA methylation site loss for plasticity-led novel trait genetic fixation. Katsumura, Takafumi Sato, Suguru Yamashita, Kana Oda, Shoji Gakuhari, Takashi Tanaka, Shodai Fujitani, Kazuko Nishimaki, Toshiyuki Imai, Tadashi Yoshiura, Yasutoshi Takeshima, Hirohiko Hashiguchi, Yasuyuki Sekita, Yoichi Mitani, Hiroshi Ogawa, Motoyuki Takeuchi, Hideaki Oota, Hiroki DNA Methylation Oryzias Epigenesis, Genetic Adaptation, Physiological Seasons CpG Islands Animals CRISPR-Cas Systems Fish Proteins Evolution, Molecular Organ Size Gastrointestinal Tract Phenotype Male Female Phenotypic plasticity allows organisms to adapt traits in response to environmental changes, yet the molecular basis by which such plastic traits become genetically fixed remains unclear. Here, we investigated gut-length plasticity in medaka fish () through genome-wide methylation profiling, CRISPR/Cas9-mediated deletion, and population genomic analyses. We found that seasonal methylation of CpG sites upstream of the is correlated with gut-length plasticity, and deletion of this region abolishes plasticity. Additionally, standing variation in is associated with genetically fixed longer gut length in populations lacking plasticity. These results suggest that loss of epigenetic regulation via CpG site reduction triggers the genetic fixation of novel traits. Our findings provide molecular evidence linking epigenetic plasticity and genetic assimilation, advancing understanding of plasticity-led evolution in natural populations.