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| Autori principali: | , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Marine drugs
2026
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| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/41892980/ |
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Sommario:
- Chrysogenones A-E: Malonyl-Modified Ergosterone Derivatives from Deep-Sea-Derived sp. MCCC 3A00121 as Inhibitors of Renal Fibroblast Activation. Li, Zeqing Chen, Lei Wang, Yuan Jiang, Mengjiao Fang, Siyu Chao, Rong Wu, Taizong Zhong, Tianhua Animals Penicillium Molecular Docking Simulation Fibroblasts Rats Kidney Cell Proliferation Cell Line Fibrosis Aquatic Organisms Five previously undescribed steroids, chrysogenones A-E (-), were isolated from the deep-sea-derived sp. MCCC 3A00121. Their chemical structures were unambiguously established through comprehensive spectroscopic analyses, density functional theory (DFT)-based electronic circular dichroism (ECD) calculations, and X-ray crystallography. Chrysogenones represent a class of oxidatively modified ergosterone-type derivatives, with , , and featuring an uncommon malonyl substitution at C-12 of the ergosterone skeleton. Biologically, - exhibited varying degrees of inhibitory activity against renal fibrosis, as evidenced by the downregulation of the key fibrotic markers α-smooth muscle actin (α-SMA) and collagen I (COL1A1). Among them, chrysogenone B () emerged as the most promising candidate, demonstrating superior potency and pronounced inhibition of activated NRK-49F cell proliferation. Integrated network pharmacology analysis and molecular docking studies further suggested that the anti-renal fibrotic effects of compound may be mediated through its interaction with putative molecular targets, including AKT1, HSP90AA1, and MDM2.