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| Main Authors: | , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
iScience
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41907418/ |
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Table of Contents:
- Temperature and pH-dependent potassium currents of muscles of the stomatogastric nervous system of the crab, . Jacquerie, Kathleen Poghosyan, Ani Schulz, David J Marder, Eve Marine crustaceans such as the crab, experience fluctuations in temperature and pH, yet their stomatogastric neuromuscular system must remain functional for feeding. We examined 16 of ∼40 stomach muscle pairs and found that warming consistently hyperpolarized muscle fibers (∼10 mV per 10°C) and reduced excitatory junctional potentials and currents. Muscle responses were also strongly influenced by extracellular pH, with an optimal range between pH 6.7 and 8.8; outside this window, abnormal activity emerged. Voltage-clamp analysis of gastric muscle gm5b revealed a temperature- and pH-sensitive conductance with a reversal potential near the potassium equilibrium potential and insensitivity to tetraethylammonium and barium, providing evidence against classical voltage-gated potassium channels. Quantitative RT-PCR detected the expression of two putative two-pore domain potassium (K2P) channels in these muscles. Together, these results suggest that muscle excitability in is shaped by temperature- and pH-sensitive potassium currents consistent with contributions from K2P channels.