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| Main Authors: | , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Cancer discovery
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41918348/ |
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| _version_ | 1868266067019694081 |
|---|---|
| author | De Blander, Hadrien Marine, Jean-Christophe |
| author_facet | De Blander, Hadrien Marine, Jean-Christophe De Blander, Hadrien Marine, Jean-Christophe |
| collection | PubMed - marine biology |
| contents | A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity. De Blander, Hadrien Marine, Jean-Christophe Humans Neoplasms Cell Plasticity We propose a physics-based framework in which cancer cell state is defined by position and velocity in a continuous space of directly measurable physical variables-cell surface area (S) and volume (V)-and motion through S-V space as an interpretable proxy for plasticity. Therapy generates S-V vector fields that govern trajectories, enabling the design of drug combinations to steer heterogeneous cell populations toward nonviable states, offering a predictive and physically interpretable alternative to therapies directed against oncogenic mutations and/or predefined cell subpopulations. |
| format | Artículo científico |
| id | pubmed_41918348 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Cancer discovery |
| record_format | pubmed |
| spellingShingle | A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity. De Blander, Hadrien Marine, Jean-Christophe Humans Neoplasms Cell Plasticity A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity. De Blander, Hadrien Marine, Jean-Christophe Humans Neoplasms Cell Plasticity We propose a physics-based framework in which cancer cell state is defined by position and velocity in a continuous space of directly measurable physical variables-cell surface area (S) and volume (V)-and motion through S-V space as an interpretable proxy for plasticity. Therapy generates S-V vector fields that govern trajectories, enabling the design of drug combinations to steer heterogeneous cell populations toward nonviable states, offering a predictive and physically interpretable alternative to therapies directed against oncogenic mutations and/or predefined cell subpopulations. |
| title | A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity. |
| topic | Humans Neoplasms Cell Plasticity |
| url | https://pubmed.ncbi.nlm.nih.gov/41918348/ |