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| Format: | Artículo científico |
| Sprache: | en |
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Environmental science & technology
2026
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/41930475/ |
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| _version_ | 1868266064379379713 |
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| author | Tan, Yisha Zou, Dayu Ni, Can Zeng, Qinglu Li, Meng |
| author_facet | Tan, Yisha Zou, Dayu Ni, Can Zeng, Qinglu Li, Meng Tan, Yisha Zou, Dayu Ni, Can Zeng, Qinglu Li, Meng |
| collection | PubMed - marine biology |
| contents | From Field Metagenomes to Mutant Genomes: Coevolution of Cyanophages and in Estuarine Ecosystems. Tan, Yisha Zou, Dayu Ni, Can Zeng, Qinglu Li, Meng Synechococcus Metagenome Estuaries Bacteriophages Ecosystem Mutation Picocyanobacteria, represented by and , are major photosynthetic organisms in aquatic ecosystems, and their viruses (cyanophages) significantly impact cyanobacterial ecology and evolution. Here, we combined metagenomics of communities along four representative estuaries in China and whole-genome analyses of laboratory-evolved mutants to link viral diversity to host adaptation and evolution. We assembled 83 cyanophage genomes (mainly cyanomyoviruses), with expanded auxiliary metabolic genes encoding glycosyltransferases and radical S-adenosyl methionine proteins involved in amino acid and lipopolysaccharide metabolism. Metagenome-assembled cyanobacterial genomes revealed mutations predominantly in membrane-associated functions linked to phage infection. In parallel, we identified genetic pathways conferring phage resistance in 18 evolved mutant strains that are resistant to phage infection. Notably, mutations in carbohydrate () and photosynthetic energy transfer () of mutants recurred in both cultured isolates and recovered metagenomes. These results indicate that cyanophages in estuaries leverage broader metabolic toolkits, while repeatedly evolves resistance. Together, these findings outline a reciprocal adaptive landscape that helps explain the persistence and turnover of picocyanobacterial populations in estuarine environments. |
| format | Artículo científico |
| id | pubmed_41930475 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Environmental science & technology |
| record_format | pubmed |
| spellingShingle | From Field Metagenomes to Mutant Genomes: Coevolution of Cyanophages and in Estuarine Ecosystems. Tan, Yisha Zou, Dayu Ni, Can Zeng, Qinglu Li, Meng Synechococcus Metagenome Estuaries Bacteriophages Ecosystem Mutation From Field Metagenomes to Mutant Genomes: Coevolution of Cyanophages and in Estuarine Ecosystems. Tan, Yisha Zou, Dayu Ni, Can Zeng, Qinglu Li, Meng Synechococcus Metagenome Estuaries Bacteriophages Ecosystem Mutation Picocyanobacteria, represented by and , are major photosynthetic organisms in aquatic ecosystems, and their viruses (cyanophages) significantly impact cyanobacterial ecology and evolution. Here, we combined metagenomics of communities along four representative estuaries in China and whole-genome analyses of laboratory-evolved mutants to link viral diversity to host adaptation and evolution. We assembled 83 cyanophage genomes (mainly cyanomyoviruses), with expanded auxiliary metabolic genes encoding glycosyltransferases and radical S-adenosyl methionine proteins involved in amino acid and lipopolysaccharide metabolism. Metagenome-assembled cyanobacterial genomes revealed mutations predominantly in membrane-associated functions linked to phage infection. In parallel, we identified genetic pathways conferring phage resistance in 18 evolved mutant strains that are resistant to phage infection. Notably, mutations in carbohydrate () and photosynthetic energy transfer () of mutants recurred in both cultured isolates and recovered metagenomes. These results indicate that cyanophages in estuaries leverage broader metabolic toolkits, while repeatedly evolves resistance. Together, these findings outline a reciprocal adaptive landscape that helps explain the persistence and turnover of picocyanobacterial populations in estuarine environments. |
| title | From Field Metagenomes to Mutant Genomes: Coevolution of Cyanophages and in Estuarine Ecosystems. |
| topic | Synechococcus Metagenome Estuaries Bacteriophages Ecosystem Mutation |
| url | https://pubmed.ncbi.nlm.nih.gov/41930475/ |