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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Scientific reports
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41933141/ |
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| _version_ | 1868266064368893952 |
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| author | Singh, Simran Damodaran, Anusree Goswami, Sanskriti Lata, Manjul Pasupuleti, Mukesh Verma, Sonia |
| author_facet | Singh, Simran Damodaran, Anusree Goswami, Sanskriti Lata, Manjul Pasupuleti, Mukesh Verma, Sonia Singh, Simran Damodaran, Anusree Goswami, Sanskriti Lata, Manjul Pasupuleti, Mukesh Verma, Sonia |
| collection | PubMed - marine biology |
| contents | Marine bacterium Stutzerimonas stutzeri mitigates Parkinson's disease pathology in C. elegans via ferroptosis modulation. Singh, Simran Damodaran, Anusree Goswami, Sanskriti Lata, Manjul Pasupuleti, Mukesh Verma, Sonia Animals Caenorhabditis elegans Parkinson Disease Ferroptosis Dopaminergic Neurons Disease Models, Animal alpha-Synuclein Neuroprotective Agents Lipid Peroxidation Parkinson's disease (PD) is a rapidly escalating neurodegenerative disorder marked by dopaminergic neurodegeneration, α-synuclein aggregation, and motor and non-motor impairments. Current therapies largely provide symptomatic relief and fail to prevent disease progression, underscoring the need for novel disease-modifying strategies. The marine biome has emerged as an unexplored reservoir of bioactive metabolites with neuroprotective potential, yet their therapeutic relevance in PD remains incompletely explored. Here, we report that Stutzerimonas stutzeri, a marine bacterium isolated from the Gulf of Mannar, exerts robust neuroprotective effects in Caenorhabditis elegans PD models. Dietary administration of S. stutzeri rescued dopaminergic neuronal loss, mitigated α-synuclein expression, and improved motor and sensory phenotypes. Mechanistic analyses revealed suppression of ferroptosis, evidenced by restoration of iron homeostasis, attenuation of lipid peroxidation, and recovery of ftn-1 expression. Our findings establish S. stutzeri as a previously unrecognized marine-derived therapeutic prospect for PD intervention and highlight ferroptosis modulation as a tractable therapeutic axis in neurodegeneration. |
| format | Artículo científico |
| id | pubmed_41933141 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Scientific reports |
| record_format | pubmed |
| spellingShingle | Marine bacterium Stutzerimonas stutzeri mitigates Parkinson's disease pathology in C. elegans via ferroptosis modulation. Singh, Simran Damodaran, Anusree Goswami, Sanskriti Lata, Manjul Pasupuleti, Mukesh Verma, Sonia Animals Caenorhabditis elegans Parkinson Disease Ferroptosis Dopaminergic Neurons Disease Models, Animal alpha-Synuclein Neuroprotective Agents Lipid Peroxidation Marine bacterium Stutzerimonas stutzeri mitigates Parkinson's disease pathology in C. elegans via ferroptosis modulation. Singh, Simran Damodaran, Anusree Goswami, Sanskriti Lata, Manjul Pasupuleti, Mukesh Verma, Sonia Animals Caenorhabditis elegans Parkinson Disease Ferroptosis Dopaminergic Neurons Disease Models, Animal alpha-Synuclein Neuroprotective Agents Lipid Peroxidation Parkinson's disease (PD) is a rapidly escalating neurodegenerative disorder marked by dopaminergic neurodegeneration, α-synuclein aggregation, and motor and non-motor impairments. Current therapies largely provide symptomatic relief and fail to prevent disease progression, underscoring the need for novel disease-modifying strategies. The marine biome has emerged as an unexplored reservoir of bioactive metabolites with neuroprotective potential, yet their therapeutic relevance in PD remains incompletely explored. Here, we report that Stutzerimonas stutzeri, a marine bacterium isolated from the Gulf of Mannar, exerts robust neuroprotective effects in Caenorhabditis elegans PD models. Dietary administration of S. stutzeri rescued dopaminergic neuronal loss, mitigated α-synuclein expression, and improved motor and sensory phenotypes. Mechanistic analyses revealed suppression of ferroptosis, evidenced by restoration of iron homeostasis, attenuation of lipid peroxidation, and recovery of ftn-1 expression. Our findings establish S. stutzeri as a previously unrecognized marine-derived therapeutic prospect for PD intervention and highlight ferroptosis modulation as a tractable therapeutic axis in neurodegeneration. |
| title | Marine bacterium Stutzerimonas stutzeri mitigates Parkinson's disease pathology in C. elegans via ferroptosis modulation. |
| topic | Animals Caenorhabditis elegans Parkinson Disease Ferroptosis Dopaminergic Neurons Disease Models, Animal alpha-Synuclein Neuroprotective Agents Lipid Peroxidation |
| url | https://pubmed.ncbi.nlm.nih.gov/41933141/ |