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| Format: | Artículo científico |
| Language: | en |
| Published: |
Proceedings of the National Academy of Sciences of the United States of America
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41950090/ |
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| _version_ | 1868266064335339521 |
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| author | Kim, Hyungbin Lee, Seunghyeon Jee, Samantha Song, Geonho Schoenaers, Dorian Delroisse, Jérôme Flammang, Patrick Harrington, Matthew J Hwang, Dong Soo |
| author_facet | Kim, Hyungbin Lee, Seunghyeon Jee, Samantha Song, Geonho Schoenaers, Dorian Delroisse, Jérôme Flammang, Patrick Harrington, Matthew J Hwang, Dong Soo Kim, Hyungbin Lee, Seunghyeon Jee, Samantha Song, Geonho Schoenaers, Dorian Delroisse, Jérôme Flammang, Patrick Harrington, Matthew J Hwang, Dong Soo |
| collection | PubMed - marine biology |
| contents | Nanocondensate bioadhesive delivery via metal-halogenated catechol coordination in tunicate rhizoid holdfasts. Kim, Hyungbin Lee, Seunghyeon Jee, Samantha Song, Geonho Schoenaers, Dorian Delroisse, Jérôme Flammang, Patrick Harrington, Matthew J Hwang, Dong Soo Catechols Animals Urochordata Dihydroxyphenylalanine Metals Adhesives The root-like holdfast of the tunicate provides strong underwater adhesion. However, the biological processing and biochemical composition underlying its adhesive remain largely unknown. Here, we identify a nanocondensate-based transport system in which halogenated 3,4-dihydroxyphenylalanine (DOPA)-containing peptides coordinate with metal ions such as iron, chromium, and vanadium to form stable nanocondensates within dense-granular cells. These nanocondensates are secreted into the extracellular matrix and rapidly incorporated into the cuticular layer, where the proteins cross-link oxidatively to form the adhesive interface, releasing the metals upon solidification. This process establishes a previously unrecognized solid-state adhesive delivery mechanism regulated by coordination chemistry between metal ions and halogenated catechols. Indeed, while other systems (e.g., mussels) use DOPA-containing proteins to transport metal ions during glue formation, the current system is distinctive in that metal coordination is transient and used ostensibly to deliver the adhesive protein cargo-findings relevant for design of next-generation underwater glues. |
| format | Artículo científico |
| id | pubmed_41950090 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Proceedings of the National Academy of Sciences of the United States of America |
| record_format | pubmed |
| spellingShingle | Nanocondensate bioadhesive delivery via metal-halogenated catechol coordination in tunicate rhizoid holdfasts. Kim, Hyungbin Lee, Seunghyeon Jee, Samantha Song, Geonho Schoenaers, Dorian Delroisse, Jérôme Flammang, Patrick Harrington, Matthew J Hwang, Dong Soo Catechols Animals Urochordata Dihydroxyphenylalanine Metals Adhesives Nanocondensate bioadhesive delivery via metal-halogenated catechol coordination in tunicate rhizoid holdfasts. Kim, Hyungbin Lee, Seunghyeon Jee, Samantha Song, Geonho Schoenaers, Dorian Delroisse, Jérôme Flammang, Patrick Harrington, Matthew J Hwang, Dong Soo Catechols Animals Urochordata Dihydroxyphenylalanine Metals Adhesives The root-like holdfast of the tunicate provides strong underwater adhesion. However, the biological processing and biochemical composition underlying its adhesive remain largely unknown. Here, we identify a nanocondensate-based transport system in which halogenated 3,4-dihydroxyphenylalanine (DOPA)-containing peptides coordinate with metal ions such as iron, chromium, and vanadium to form stable nanocondensates within dense-granular cells. These nanocondensates are secreted into the extracellular matrix and rapidly incorporated into the cuticular layer, where the proteins cross-link oxidatively to form the adhesive interface, releasing the metals upon solidification. This process establishes a previously unrecognized solid-state adhesive delivery mechanism regulated by coordination chemistry between metal ions and halogenated catechols. Indeed, while other systems (e.g., mussels) use DOPA-containing proteins to transport metal ions during glue formation, the current system is distinctive in that metal coordination is transient and used ostensibly to deliver the adhesive protein cargo-findings relevant for design of next-generation underwater glues. |
| title | Nanocondensate bioadhesive delivery via metal-halogenated catechol coordination in tunicate rhizoid holdfasts. |
| topic | Catechols Animals Urochordata Dihydroxyphenylalanine Metals Adhesives |
| url | https://pubmed.ncbi.nlm.nih.gov/41950090/ |